IL6ST, interleukin 6 signal transducer, 3572

N. diseases: 260; N. variants: 6
Disease: Mass of body region ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0577573
Disease: Mass of body region
Mass of body region 		0.010 Biomarker phenotype BEFREE In a mouse model of spontaneous osteopenia caused by hyperactivation of STAT1/3 signaling downstream of gp130 (gp130<sup>Y757F/Y757F</sup>), STAT1 deletion rescued the osteopenic phenotype, indicating a beneficial effect of promoting STAT3 signaling over STAT1 downstream of gp130 in this low bone mass condition, and this may have therapeutic value. 27539849 2016