|
Abnormality of the metaphysis
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Acquired Immunodeficiency Syndrome
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Interleukin-7 receptor gene polymorphism at +1237 locus and its effect on susceptibility to opportunistic infections among HIV and AIDS patients in Limpopo Province, South Africa.
|
25366767 |
2014 |
|
Acute Coronary Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
The spontaneous apoptosis of Treg cells (defined as CD4(+)CD25(+)CD127(low)annexin V(+)7-AAD(-)) was increased in the NSTACS patients compared with the CSA and CPS groups.
|
22872639 |
2012 |
|
Acute GVH disease
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, the IL-7Rα <i>rs6897932</i> genotype of the donor is predictive of aGVHD and cGVHD, CMV infection, and mortality following HSCT.
|
29456530 |
2018 |
|
Acute GVH disease
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Soluble Interleukin-7 receptor levels and risk of acute graft-versus-host disease after allogeneic haematopoietic stem cell transplantation.
|
28863969 |
2018 |
|
Acute infectious disease
|
0.010 |
AlteredExpression
|
group |
BEFREE |
In contrast, HCV-specific CD8(+) T cells in acute infections evolving to chronicity expressed low levels of CD127 and Bcl-2, exhibited diminished proliferation and cytokine production, and eventually disappeared from the periphery.
|
18667516 |
2008 |
|
Acute leukemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Our data suggest that the IL7R mutations may contribute to the development of diverse types of acute leukemias, and that possible therapies targeting the IL7R exon 6 mutation should include not only childhood T-ALL but also T-ALL, childhood precursor B-ALL, and adult AML.
|
23069254 |
2013 |
|
Acute lymphoblastic leukemia with lymphomatous features
|
0.100 |
GeneticVariation
|
disease |
CLINVAR |
Genetic alterations activating kinase and cytokine receptor signaling in high-risk acute lymphoblastic leukemia.
|
22897847 |
2012 |
|
Acute lymphoblastic leukemia with lymphomatous features
|
0.100 |
GeneticVariation
|
disease |
CLINVAR |
Targeting JAK1/2 and mTOR in murine xenograft models of Ph-like acute lymphoblastic leukemia.
|
22955920 |
2012 |
|
Acute lymphocytic leukemia
|
0.090 |
Biomarker
|
disease |
BEFREE |
As YB-1 mediates some of its activity through growth factor receptor signaling dysregulation, the present study compared the expression of YB-1 and interleukin 7 (IL-7) receptor α (IL-7Rα) in pediatric B-cell precursor (BCP) acute lymphoblastic leukemia (ALL) and normal BCP cells.
|
28123588 |
2017 |
|
Acute lymphocytic leukemia
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
Here, we explored the IL7R and SH2B3 expression in adult ALL and found that IL7R is significantly higher and Sh2B3 lower expressed in B-ALL compared to normal bone marrow control, and the IL7RhighSH2B3low is associated with high-risk factors, and with high relapse rate and low disease-free survival rate in the patients.
|
27322554 |
2016 |
|
Acute lymphocytic leukemia
|
0.090 |
Biomarker
|
disease |
BEFREE |
Activating mutations that target JAK2, as well as JAK1, or CRLF2 and IL7RA, two cytokine receptors with which the JAKs associate in lymphoid cells, have now been identified in a subset of pediatric patients diagnosed with acute lymphoblastic leukemia (ALL), many of whom have a poor prognosis.
|
23340138 |
2013 |
|
Acute lymphocytic leukemia
|
0.090 |
Biomarker
|
disease |
BEFREE |
Here, we present detailed data on the expression of the interleukin 7 receptor alpha chain (IL-7Ralpha) in leukaemic cells from 210 children with acute lymphoblastic leukaemia (ALL) and describe two novel alternatively spliced transcripts of human IL-7Ralpha coding for truncated receptor proteins which are still capable of binding IL-7.
|
11052810 |
2000 |
|
Acute lymphocytic leukemia
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
As controversy exists regarding the prognostic significance of genomic rearrangements of CRLF2 in pediatric B-precursor acute lymphoblastic leukemia (ALL) classified as standard/intermediate-risk (SR) or high-risk (HR), we assessed the prognostic significance of CRLF2 mRNA expression, CRLF2 genomic lesions (IGH@-CRLF2, P2RY8-CRLF2, CRLF2 F232C), deletion/mutation in genes frequently associated with high CRLF2 expression (IKZF1, JAK, IL7R), and minimal residual disease (MRD) in 1061 pediatric ALL patients (499 HR and 562 SR) on COG Trials P9905/P9906.
|
22368272 |
2012 |
|
Acute lymphocytic leukemia
|
0.090 |
Biomarker
|
disease |
BEFREE |
Gain-of-function somatic mutations introducing cysteines to either the extracellular or to the transmembrane domain (TMD) in interleukin-7 receptor α (IL7R) or cytokine receptor-like factor 2 (CRLF2) have been described in acute lymphoblastic leukemias.
|
24787007 |
2014 |
|
Acute lymphocytic leukemia
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
Here, we describe somatic gain-of-function mutations in IL7R in pediatric B and T acute lymphoblastic leukemias.
|
21536738 |
2011 |
|
Acute lymphocytic leukemia
|
0.090 |
Biomarker
|
disease |
BEFREE |
Expression of human c-kit proto-oncogene and interleukin-7 receptor (IL-7R) in acute lymphoblastic leukemia (ALL) cells expressing CD7 was examined by Northern-blot analysis and reversed transcription polymerase chain reaction (RT-PCR) assay in relation to the phenotypes.
|
1378163 |
1992 |
|
Acute lymphocytic leukemia
|
0.090 |
Biomarker
|
disease |
BEFREE |
BET bromodomain inhibition targets both c-Myc and IL7R in high-risk acute lymphoblastic leukemia.
|
22904298 |
2012 |
|
Acute monocytic leukemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Overall, we found 10 IL7R exon 6 mutations in seven hematologic malignancies (three childhood T-ALL [12%], one adult T-ALL [7%], two childhood precursor B-cell acute lymphoblastic leukemia (B-ALL) [2%] and one adult acute myelogenous leukemia (AML) [1%]) and three nonhematopoietic malignancies (one lung cancer [0.6%] and two colorectal cancer [0.5%]), but none in other tumors.
|
23069254 |
2013 |
|
Acute pancreatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
CD4 + CD25 + CD127 high cells as a negative predictor of multiple organ failure in acute pancreatitis.
|
28174597 |
2017 |
|
Acute Promyelocytic Leukemia
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The MAIT cells from the FGT and blood displayed a distinct phenotype with expression of interleukin (IL)-18Rα, CD127, α4β7, PD-1, as well as the transcription factors promyelocytic leukemia zinc finger (PLZF), RORγt, Helios, Eomes, and T-bet.
|
27049062 |
2017 |
|
Acute Promyelocytic Leukemia
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Here, we show that Id2 also drives development of human ILC because forced expression of Id2 in human thymic progenitors blocked T cell commitment, upregulated CD161 and promyelocytic leukemia zinc finger (PLZF), and maintained CD127 expression, markers that are characteristic for human ILCs.
|
28912776 |
2017 |
|
Adenocarcinoma of lung (disorder)
|
0.010 |
Biomarker
|
disease |
BEFREE |
This knowledge may lead to the development of immunotherapies that could inhibit the suppressor activity mediated by the LAP TGF-β subset of CD4(+)CD25(+)CD127(-) Treg cells to promote reactivity of immune cells against lung adenocarcinoma cells.
|
26582240 |
2015 |
|
Adult Acute Lymphocytic Leukemia
|
0.050 |
Biomarker
|
disease |
BEFREE |
As YB-1 mediates some of its activity through growth factor receptor signaling dysregulation, the present study compared the expression of YB-1 and interleukin 7 (IL-7) receptor α (IL-7Rα) in pediatric B-cell precursor (BCP) acute lymphoblastic leukemia (ALL) and normal BCP cells.
|
28123588 |
2017 |
|
Adult Acute Lymphocytic Leukemia
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
Here, we explored the IL7R and SH2B3 expression in adult ALL and found that IL7R is significantly higher and Sh2B3 lower expressed in B-ALL compared to normal bone marrow control, and the IL7RhighSH2B3low is associated with high-risk factors, and with high relapse rate and low disease-free survival rate in the patients.
|
27322554 |
2016 |