|
Herpes NOS
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Thus, combined analyses of IL-7Rα and KLRG1 expression on human herpes virus-specific CD8<sup>+</sup> T cells can be used to separate functionally distinct subsets in humans.
|
30883723 |
2019 |
|
Neoplasm Metastasis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Collectively, these data suggest that IL-7 and/or IL-7Rα are promising targets of inhibiting tumor metastasis.
|
31061414 |
2019 |
|
Nephritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Compared with the control group, ILCs (Lin-CD127+CD45+ cells) were higher in SLE patients (p<0.01), and the distribution of ILC population changed between groups, ILC1 (Lin-CD127+CD45+CRTH2-CD117-cells)/ILC3 (Lin-CD127+CD45+CRTH2-CD-117+cells) count increased (p<0.0001) and correlated with nephritis and disease activity.
|
30789153 |
2019 |
|
Degenerative polyarthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
DEGs in patients suffering from RA compared with patients suffering from OA were predominantly associated with the primary immunodeficiency pathway, including interleukin 7 receptor (IL7R) and signal transducer activator of transcription 1 (STAT1).
|
30483789 |
2019 |
|
Septicemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Some candidate biomarkers, including mid-regional proadrenomedullin, the percentage of human leukocyte antigen DR (HLA-DR)-positive monocytes, means of fluorescence intensities of HLA-DR on monocytes, interleukin-7 receptor expression levels, immunoglobulin M levels in the serum or the absence of increased proteolysis, have already demonstrated the potential to exclude the risk of progression to septic shock, nosocomial infections, and mortality when tested along the sepsis course.
|
31018868 |
2019 |
|
Secondary malignant neoplasm of bone
|
0.010 |
Biomarker
|
disease |
BEFREE |
Importantly, lentiviral delivery of IL-7Rα to PC-3 cells significantly increased bone metastasis in an experimental murine metastasis model compared to controls.
|
31061414 |
2019 |
|
Autoimmune Chronic Hepatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
CD127⁺ Treg and Foxp3⁺ Treg expressions were decreased in the AIH group compared to the HC group (p<0.05).
|
31422415 |
2019 |
|
Malignant neoplasm of prostate
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The gene expression profile of human prostate cancer cells from The Cancer Genome Atlas revealed that EMT pathways are strongly associated with prostate cancers that highly express both IL-7 and IL-7Rα.
|
31061414 |
2019 |
|
Ischemic stroke
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results suggest that the formation of the ternary TSLPR : TSLP : IL-7Rα complex may activate STAT5 or a STAT5-related signaling pathway to mediate neuroinflammation in ischemic stroke.
|
30676545 |
2019 |
|
Secondary Neoplasm
|
0.010 |
Biomarker
|
group |
BEFREE |
Collectively, these data suggest that IL-7 and/or IL-7Rα are promising targets of inhibiting tumor metastasis.
|
31061414 |
2019 |
|
Autoimmune hepatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
CD127⁺ Treg and Foxp3⁺ Treg expressions were decreased in the AIH group compared to the HC group (p<0.05).
|
31422415 |
2019 |
|
Malignant tumor of cervix
|
0.010 |
Biomarker
|
disease |
BEFREE |
Up-regulation of inflammation-related LncRNA-IL7R predicts poor clinical outcome in patients with cervical cancer.
|
29720427 |
2018 |
|
Cytomegalovirus Infections
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Donor Genotype in the Interleukin-7 Receptor α-Chain Predicts Risk of Graft-versus-Host Disease and Cytomegalovirus Infection after Allogeneic Hematopoietic Stem Cell Transplantation.
|
29456530 |
2018 |
|
Kidney Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
In this study, we found that the interleukin-7 receptor (IL-7R) was induced in the glomeruli of adriamycin (ADR)-induced mouse nephropathy, a rodent model of nephrotic syndrome.
|
30454893 |
2018 |
|
Respiratory Distress Syndrome, Adult
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Plasma lnc-IL7R was significantly down-regulated in ARDS compared with the levels in healthy control individuals, especially in severe ARDS (P < .01).
|
28960939 |
2018 |
|
Fibrosis, Liver
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In the present study, we analyzed the association between IL7RA polymorphisms and the progression of liver fibrosis in patients infected with HCV.
|
29742149 |
2018 |
|
Nevus comedonicus
|
0.010 |
Biomarker
|
disease |
BEFREE |
Higher percentages of Tr1, CD4+CD25+FOXP3+CD127- and CD4+CD45RO+FOXP3HI were found in NC patients compared with healthy controls, but no difference was found in catecholamine levels.
|
30041237 |
2018 |
|
Squamous cell carcinoma of esophagus
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Oncogenic IL7R is downregulated by histone deacetylase inhibitor in esophageal squamous cell carcinoma via modulation of acetylated FOXO1.
|
29749437 |
2018 |
|
Cervix carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Up-regulation of inflammation-related LncRNA-IL7R predicts poor clinical outcome in patients with cervical cancer.
|
29720427 |
2018 |
|
Neurodegenerative Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
Il7r is involved in the pathogenesis of neurodegenerative disorders, such as multiple sclerosis.
|
29449560 |
2018 |
|
Hepatitis C, Chronic
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The IL7RA rs6897932 polymorphism is associated with progression of liver fibrosis in patients with chronic hepatitis C: Repeated measurements design.
|
29742149 |
2018 |
|
Carcinogenesis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
These data indicate that IL-7Rα is involved in BC, and that IL7RA polymorphism may play distinct roles in breast carcinogenesis according to BC subtype, pointing this genetic variant as an interesting marker for breast carcinogenesis to be validated by further mechanistic and prospective studies with larger samples.
|
28964592 |
2018 |
|
Spondylarthritis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
CD4 T cells in 98 blood samples of patients with RA (n = 78) or SpA (n = 20) were quantified by flow cytometry after stimulation with VZV antigen and the polyclonal stimulus Staphylococcus aureus enterotoxin B (SEB), and they were characterized for expression of cytokines (interferon-γ, tumor necrosis factor [TNF]-α, interleukin [IL]-2) and markers for activation (CD69), differentiation (CD127), or functional anergy programmed death 1 molecule [PD-1], cytotoxic T-lymphocyte antigen 4 [CTLA-4].
|
30413189 |
2018 |
|
Sjogren's Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
Intraperitoneal administration of a blocking antibody against the IL-7 receptor α chain (IL-7Rα) to female NOD mice aged 10 weeks, which exhibited newly onset clinical SS, for the duration of 3 weeks significantly ameliorated characteristic SS pathologies including hyposalivation and leukocyte infiltration of the submandibular glands (SMGs).
|
29680668 |
2018 |
|
Infantile nystagmus syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
Together, these results identify IL-7 and its receptor IL-7R as potential regulators of podocyte function, which might offer a novel therapeutic target in the treatment of INS.
|
30454893 |
2018 |