IL7R, interleukin 7 receptor, 3575

N. diseases: 231; N. variants: 41
Disease: Childhood T Acute Lymphoblastic Leukemia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0279583
Disease: Childhood T Acute Lymphoblastic Leukemia
Childhood T Acute Lymphoblastic Leukemia 		0.040 GeneticVariation disease BEFREE Because the treatment response of adult T-ALL is significantly poorer than that of childhood T-ALL and because exon 6 IL7R mutations play a role in the pathogenesis of childhood T-ALL, we sought to determine how the pattern of IL7R mutations varies between adult and childhood T-ALL. 24678068 2014
CUI: C0279583
Disease: Childhood T Acute Lymphoblastic Leukemia
Childhood T Acute Lymphoblastic Leukemia 		0.040 GeneticVariation disease BEFREE Our data suggest that the IL7R mutations may contribute to the development of diverse types of acute leukemias, and that possible therapies targeting the IL7R exon 6 mutation should include not only childhood T-ALL but also T-ALL, childhood precursor B-ALL, and adult AML. 23069254 2013
CUI: C0279583
Disease: Childhood T Acute Lymphoblastic Leukemia
Childhood T Acute Lymphoblastic Leukemia 		0.040 GeneticVariation disease BEFREE Confirming this notion, oncogenic IL7R gain-of-function mutations have recently been identified in childhood T-ALL. 22695916 2012
CUI: C0279583
Disease: Childhood T Acute Lymphoblastic Leukemia
Childhood T Acute Lymphoblastic Leukemia 		0.040 GeneticVariation disease BEFREE Oncogenic IL7R gain-of-function mutations in childhood T-cell acute lymphoblastic leukemia. 21892159 2011