IL7R, interleukin 7 receptor, 3575

N. diseases: 231; N. variants: 41
Disease: Childhood Leukemia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.040 AlteredExpression disease BEFREE Notably, we show that IL-7R-dependent LIC activity and leukemia progression can be extended to human B-cell acute lymphoblastic leukemia (B-ALL). 31530562 2019
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.040 GeneticVariation disease BEFREE Interleukin-7 receptor mutants initiate early T cell precursor leukemia in murine thymocyte progenitors with multipotent potential. 24687960 2014
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.040 GeneticVariation disease BEFREE Our current and recent observations of mutations in IL7R and CRLF2, respectively suggest that the addition of cysteine to the juxtamembranous domains is a general mechanism for mutational activation of type I cytokine receptors in leukemia. 21536738 2011
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.040 AlteredExpression disease BEFREE CSL-MAML-dependent Notch1 signaling controls T lineage-specific IL-7R{alpha} gene expression in early human thymopoiesis and leukemia. 19349467 2009