|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
These results suggest that overall IL-8 -251 A/T gene polymorphism is not associated with the risk of GC and the association may be varied according to histological type, tumor location, H. pylori infection and ethnicity/country.
|
20363644 |
2010 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
A significant association was demonstrated between the IL-8 (-251) AA genotype and the aggressive forms of NPC as defined by large tumor size, lymph node metastasis, and advanced stages.
|
17869651 |
2007 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The presence of two higher risk genotypes (the TA and TT in IL-8, and the TT in CXCR2) significantly increased the risk of developing breast carcinoma (adjusted OR = 4.15; P = 0.0004).The CXCR2 (+ 1208) T allele manifested a significant association with an aggressive phenotype of breast carcinoma as defined by a large tumor size, a high histological grade, and auxiliary's lymph node metastasis.
|
20540789 |
2010 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
A significant association between the IL-8 (-251) AA homozygous genotype and the aggressive phenotype of breast carcinoma as defined by the high histological grade, auxiliary's lymph node metastasis, and large tumor size was found.
|
16698420 |
2006 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The Interleukin 8-251A > T SNP was significantly correlated with an increased tumor (p = 0.048), PTE (p = 0.033) and necrosis volume (p = 0.028).
|
26603163 |
2016 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Moreover, a significantly increased risk of NSCLC was associated with IL-8 +781C allele in patients with large tumor size (T3 and T4) (P=0.004).
|
23831257 |
2013 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Furthermore, the reduced tumor growth in the combination group is associated with decreased tumor levels of S536P-p65 NFκB and its decreased recruitment to IL-8 promoter in tumor tissues.
|
26267322 |
2015 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The analysis revealed an interaction between IL8 -251A>T and IL32 rs28372698 SNPs among cases with moderately- or well-differentiated tumors.
|
24982364 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
An intravasation-sustaining mode of intratumoral angiogenic vessels depends on high levels of tumor cell EGFR and the interplay between EGFR-regulated production of interleukin 8 by tumor cells, interleukin-8-induced influx of tumor-infiltrating neutrophils delivering their unique matrix metalloproteinase-9, and neutrophil matrix metalloproteinase-9-dependent release of the vascular permeability and endothelial growth factor, VEGF.
|
26408256 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Since IL-8 promotes neutrophil chemotaxis and degranulation during inflammatory responses, and exerts mitogenic and angiogenic actions within tumor microenvironment, our results imply that myeloid RUNX3 expression regulates the recruitment of leukocytes towards inflammatory foci and might also contribute to human cancer progression.
|
20615577 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We demonstrate here that CXCR2-expressing CAR T-cells migrate more efficiently towards IL-8 and towards tumor conditioned media that contains this cytokine.
|
31091832 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Tumor-associated macrophage-derived IL-6 and IL-8 enhance invasive activity of LoVo cells induced by PRL-3 in a KCNN4 channel-dependent manner.
|
24885636 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
This model system was used to examine the role of both endothelial cell Bcl-2 and the proangiogenic chemokine interleukin-8 (IL-8) on tumor growth and intratumoral microvascular density.
|
11280784 |
2001 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Tumors from MyD88-KD or TLR5-KD cells revealed the reduced production of neutrophil attracting chemokines (epithelial cell-derived neutrophil-activating peptide-78, macrophage-inflammatory protein alpha, and interleukin-8).
|
18538140 |
2008 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In vitro studies demonstrated functional co-operation of tumor-derived CXCL8 with stromal-derived chemokines.
|
24970800 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
To study the effect of localised secretion of chemokines on tumour growth, the genes for human (hu) interleukin 8 (IL-8), hu-MCP-1 (MCAF), hu-MIP-1 alpha (LD78), murine (mu)-MCP-1 (JE), mu-MIP-1 alpha or mu-MIP-2 were introduced, via mammalian expression vectors, into Chinese hamster ovary (CHO) cells, and the ability of transfected cells to form tumours in vivo was evaluated.
|
7669585 |
1995 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
CXCL8 and its receptors, CXCR1 and CXCR2, were found to play important roles in tumor proliferation, migration, survival, and growth.
|
31571912 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Short hairpin RNA-expressing oncolytic adenovirus-mediated inhibition of IL-8: effects on antiangiogenesis and tumor growth inhibition.
|
18273054 |
2008 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Mechanistically, we demonstrate that STAT3 controls NF-κB-induced IL-8 expression by sequestering NF-κB within the cytoplasm, thereby inhibiting IL-8-mediated myeloid tumour infiltration and tumour vascularization and hence tumour progression.
|
25734337 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Recently, IL8 was identified in ACC and NCI-H295R cells, and was found to contribute to ACC tumour growth.
|
17578764 |
2007 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The expression levels of basic fibroblast growth factor (bFGF), vascular endothelial growth factor (VEGF), interleukin-8 (IL-8), matrix metalloproteinases (MMP)-2 and -9, and E-cadherin were examined at the periphery of the tumor by a colorimetric in situ mRNA.
|
11159211 |
2001 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Angiogenesis is a prime regulator of tumour expansion and data support that IL-8 is a potent angiogenic factor.
|
22108905 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
IL-8 plays an integral role in promoting the malignant phenotype in breast cancer, and its production is directly influenced by inflammatory cytokines in the tumor microenvironment.
|
15514971 |
2005 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Among its interactors, the CTSK gene and the IL8 gene participated in the toll-like receptor signaling pathway which is closely related to tumor occurrence.
|
24452295 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Here, we use RNA interference to target CXCL8 and its receptor, CXCR1, to establish the existence of a functional signaling pathway promoting tumor growth initiated by sporadic and colitis CCSCs.
|
30738331 |
2019 |