Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In conclusion, IL8 expression in the tumor microenvironment is associated with aggressive prostate cancer and with AR loss in metastatic disease.
|
31604846 |
2020 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We demonstrate here that CXCR2-expressing CAR T-cells migrate more efficiently towards IL-8 and towards tumor conditioned media that contains this cytokine.
|
31091832 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
CXCL8 and its receptors, CXCR1 and CXCR2, were found to play important roles in tumor proliferation, migration, survival, and growth.
|
31571912 |
2019 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
IL-8 expression in tumour tissue sections was analysed by immunohistochemistry.
|
31673102 |
2019 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Furthermore, although the nonloading group increased the tumor bearing as well as expression of IL-8 and matrix metalloproteinase 9, ankle loading decreased them.
|
31266364 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Here, we use RNA interference to target CXCL8 and its receptor, CXCR1, to establish the existence of a functional signaling pathway promoting tumor growth initiated by sporadic and colitis CCSCs.
|
30738331 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Tumor-educated MAIT cells significantly upregulated inhibitory molecules like PD-1, CTLA-4, TIM-3, secreted significantly less IFNγ and IL17, and produced minimal granzyme B and perforin while shifting to produce tumor-promoting cytokines like IL8.
|
30723143 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In vitro culture of fresh tumour tissue was performed to evaluate the potential therapeutic effect of blocking CXCL8 pathway in gastric cancer.
|
30661053 |
2019 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Lastly, Treg-secreted high level of IL-8 further induced TGF-β production from TAMs, and promoted the immunosuppressive tumor microenvironment in MPE.
|
30928379 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Furthermore, IL-8 knockdown significantly delayed PDX GBM tumor growth in vivo (p < 0.0005).
|
30926789 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The JNK/IL-8 were identified as downstream molecules of pMLKL during necroptosis, and inhibition of JNK, IL-8 or IL-8 receptor significantly reduced tumor repopulation after radiotherapy.
|
31706322 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Influence of Interleukin-8 and Neutrophil Extracellular Trap (NET) Formation in the Tumor Microenvironment: Is There a Pathogenic Role?
|
31093511 |
2019 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Tumor Transcriptome Reveals High Expression of IL-8 in Non-Small Cell Lung Cancer Patients with Low Pectoralis Muscle Area and Reduced Survival.
|
31455042 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Together, these data demonstrate a paracrine bi-directional interaction between pancreatic tumor cells and the CAFs through CXCL8 and FGF-2 that helps the tumor growth.
|
31025289 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The aim of the current study was to measure serum concentrations of chemokine CXCL-8 in OC patients and establish whether this protein might be considered a potential candidate for a tumor marker in the diagnosis and progression of OC.
|
30820705 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Notch-Mediated Tumor-Stroma-Inflammation Networks Promote Invasive Properties and CXCL8 Expression in Triple-Negative Breast Cancer.
|
31105691 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We studied IL-6 and IL-8 function in primary oesophageal squamous carcinoma and NK cell co-cultures in vitro and by a xenograft tumour model in vivo.
|
31324197 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The infected cells were purified and coerced into quiescence using a defined cocktail of cytokines, including tumor growth factor beta, interleukin-10 (IL-10), and IL-8, producing a homogeneous population of latently infected cells.
|
30914509 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Furthermore, suppressing IL-8 inhibited tumor growth and metastasis and reduced CTC seeding in primary tumors in vitro and in vivo.
|
31366916 |
2019 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
SMAD4 knockdown from human colorectal cancer cells upregulated the expression of CXCL1 and CXCL8, which recruited neutrophils to colorectal cancer tumor via CXCR2.
|
30705034 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
IL-8 promoted the EMT process in ameloblastoma tumor cells in vitro, as evidenced by decreased E-cadherin and increased vimentin, twist and zeb1 levels.
|
31397928 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Interleukin-8 (IL-8), an important member of the CXC chemokine family that was originally classified as a potent neutrophil chemoattractant, has been shown to serve an important role in inflammation, tumor growth, invasion and metastasis through interactions with its receptors.
|
31516616 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Overall, our studies identify novel tumor-stroma-inflammation networks that may promote TNBC aggressiveness by increasing the pro-malignancy potential of the TME and of the tumor cells themselves, and reveal key roles for CXCL8 in mediating these metastasis-promoting activities.
|
31031757 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Metformin interrupts bidirectional signaling between tumor and mesothelial cells by blocking OvCa cell TGF-β signaling and mesothelial cell production of CCL2 and IL-8.
|
31851935 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
<i>FOXP3</i> protein expression in neutrophils and the amount of IL-8 protein in the OSCC tumor microenvironment were determined by immunofluorescence analysis.
|
31611987 |
2019 |