|
Rheumatoid Arthritis
|
0.400 |
Biomarker
|
disease |
BEFREE |
We have shown in this report, for the first time, the abundance of one such factor, interleukin 8 (IL 8), in the synovial fluid of patients both with RA and other non-RA joint diseases, and the spontaneous production of IL 8 mRNA by RA synovial cells in culture.
|
2209707 |
1990 |
|
Liver carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Two human hepatoma cell lines (SK-Hep and Hep-G2) displayed a time- and dose-dependent increase in steady state levels of NCF/IL-8 mRNA and secretion of chemotactic activity in response to TNF and IL-1.
|
2156928 |
1990 |
|
Liver neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
Two human hepatoma cell lines (SK-Hep and Hep-G2) displayed a time- and dose-dependent increase in steady state levels of NCF/IL-8 mRNA and secretion of chemotactic activity in response to TNF and IL-1.
|
2156928 |
1990 |
|
Fibrosarcoma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Transfection of a human fibrosarcoma cell line with chloramphenicol acetyltransferase expression plasmids linked to a 5'-flanking deletion mutants of the IL-8 gene demonstrated that the nucleotides between -94 and -71 base pairs from the start of the first exon are essential and sufficient for the IL-8 induction by either IL-1, TNF, or phorbol 12-myristate 13-acetate.
|
2250017 |
1990 |
|
Adult Fibrosarcoma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Transfection of a human fibrosarcoma cell line with chloramphenicol acetyltransferase expression plasmids linked to a 5'-flanking deletion mutants of the IL-8 gene demonstrated that the nucleotides between -94 and -71 base pairs from the start of the first exon are essential and sufficient for the IL-8 induction by either IL-1, TNF, or phorbol 12-myristate 13-acetate.
|
2250017 |
1990 |
|
Giant cell carcinoma of lung
|
0.020 |
Biomarker
|
disease |
BEFREE |
Coding region structure of interleukin-8 gene of human lung giant cell carcinoma LU65C cells that produce LUCT/interleukin-8: homogeneity in interleukin-8 genes.
|
2200751 |
1990 |
|
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Several human astrocytoma and glioblastoma cell lines expressed high levels of IL-8 and MCAF mRNA in vitro upon stimulation with IL-1 and TNF-alpha.
|
1937574 |
1991 |
|
Glioblastoma Multiforme
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Several human astrocytoma and glioblastoma cell lines expressed high levels of IL-8 and MCAF mRNA in vitro upon stimulation with IL-1 and TNF-alpha.
|
1937574 |
1991 |
|
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Cell-associated interleukin-8 antigen was present in SK-hepatoma and primary hepatocytes that had been incubated with macrophage-conditioned medium, tumor necrosis factor or interleukin-1 beta.
|
1660018 |
1991 |
|
Pulmonary Fibrosis
|
0.340 |
AlteredExpression
|
disease |
BEFREE |
The level of IL-8 mRNA in alveolar macrophages was found to be significantly elevated in individuals with lone IPF or with lung fibrosis associated with connective tissue disorders compared to normal healthy controls.
|
1752942 |
1991 |
|
Astrocytoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In particular, an astrocytoma cell line U373MG subclone responded markedly to IL-1 with high expression levels of IL-8 and MCAF mRNA as well as IL-6 mRNA.
|
1937574 |
1991 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These data suggest that IL-8 and MCAF may play a role in growth regulation and spreading of melanomas.
|
1875058 |
1991 |
|
Psoriasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Cellular localization of interleukin-8 and its inducer, tumor necrosis factor-alpha in psoriasis.
|
1702929 |
1991 |
|
Psoriasis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In this case, local pharmacologic down-regulation of NAP-1/IL-8 activity could be a promising therapeutic strategy in PS.
|
1711550 |
1991 |
|
Respiratory Syncytial Virus Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
We have investigated if RSV infection of AM results in the production of cytokines TNF, IL-6, and IL-8, all of which may modulate inflammatory and immune responses to the virus, as well as may directly protect respiratory epithelial cells against spread of infection.
|
1753101 |
1991 |
|
Virus Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
However, TNF, IL-1, and RSV, but not IL-6, induced IL-8 and IL-6 mRNA expression by the bronchial epithelial cells suggesting that cytokines produced by RSV-infected AM may be more important in modulating the inflammatory response in infection than directly interfering with virus infection/replication of airway epithelium.
|
1753101 |
1991 |
|
Adult Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Several human astrocytoma and glioblastoma cell lines expressed high levels of IL-8 and MCAF mRNA in vitro upon stimulation with IL-1 and TNF-alpha.
|
1937574 |
1991 |
|
Childhood Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Several human astrocytoma and glioblastoma cell lines expressed high levels of IL-8 and MCAF mRNA in vitro upon stimulation with IL-1 and TNF-alpha.
|
1937574 |
1991 |
|
Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
However, TNF, IL-1, and RSV, but not IL-6, induced IL-8 and IL-6 mRNA expression by the bronchial epithelial cells suggesting that cytokines produced by RSV-infected AM may be more important in modulating the inflammatory response in infection than directly interfering with virus infection/replication of airway epithelium.
|
1753101 |
1991 |
|
Idiopathic Pulmonary Fibrosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
These data suggest that IL-8 derived from alveolar macrophages may significantly contribute to neutrophil involvement in the pathogenesis of IPF.
|
1752942 |
1991 |
|
Childhood Astrocytoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In particular, an astrocytoma cell line U373MG subclone responded markedly to IL-1 with high expression levels of IL-8 and MCAF mRNA as well as IL-6 mRNA.
|
1937574 |
1991 |
|
Liver neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
Cell-associated interleukin-8 antigen was present in SK-hepatoma and primary hepatocytes that had been incubated with macrophage-conditioned medium, tumor necrosis factor or interleukin-1 beta.
|
1660018 |
1991 |
|
Leukocytosis
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
These data suggest that IL-1 and TNF-alpha induce astrocytes to produce IL-8 and MCAF transcriptionally and post-transcriptionally, both of which may be responsible for leucocytosis seen in inflammation of the CNS.
|
1937574 |
1991 |
|
Connective Tissue Diseases
|
0.010 |
AlteredExpression
|
group |
BEFREE |
The level of IL-8 mRNA in alveolar macrophages was found to be significantly elevated in individuals with lone IPF or with lung fibrosis associated with connective tissue disorders compared to normal healthy controls.
|
1752942 |
1991 |
|
Rheumatoid Arthritis
|
0.400 |
Biomarker
|
disease |
BEFREE |
These data suggest a function for macrophage-derived IL-8 in angiogenesis-dependent disorders such as rheumatoid arthritis, tumor growth, and wound repair.
|
1281554 |
1992 |