|
Rheumatoid Arthritis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We have therefore examined the ability of engagement of MHC class II molecules by the superantigen Staphylococcal enterotoxin A (SEA) to activate interleukin 6 (IL-6) and IL-8 gene expression in type B synoviocytes isolated from patients with rheumatoid arthritis.
|
1732419 |
1992 |
|
Malignant neoplasm of stomach
|
0.400 |
Biomarker
|
disease |
BEFREE |
The production of IL-8 protein was detected by enzyme-linked immunosorbent assay in the culture supernatants derived from eight of nine human gastric cancer cell lines stimulated with either interleukin 1 alpha (IL-1 alpha), tumor necrosis factor alpha (TNF alpha), or TNF alpha plus interferon gamma (IFN gamma).
|
1331059 |
1992 |
|
Arthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Cartilage and joint inflammation. Regulation of IL-8 expression by human articular chondrocytes.
|
1729366 |
1992 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We provide, in this study, direct evidence of an increased expression of granulocyte-macrophage-colony-stimulating factor, interleukin-6, and interleukin-8 genes and proteins in bronchial epithelium from patients with symptomatic asthma.
|
1583242 |
1992 |
|
Astrocytoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
IL-8 activity was produced constitutively in all astrocytomas and increased markedly upon stimulation with IL-1 beta or TNF alpha, in both a time- and dose-dependent fashion.
|
1407609 |
1992 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
From these results, it is suspected that astroglial cell-derived IL-8 may take part in neutrophil-mediated inflammation which accompanies infection, degeneration and malignancy in the brain.
|
1407609 |
1992 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Our data suggest that secretion of IL-8 by malignant cells may partly account for the inflammatory infiltrates associated with some malignant neoplasms.
|
1739130 |
1992 |
|
Renal Cell Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this report, the authors demonstrate that human transitional cell carcinomas and renal cell carcinomas have the capacity to elaborate IL-8 in response to the inflammatory mediators IL-1 beta and tumor necrosis factor (TNF)-alpha.
|
1739130 |
1992 |
|
Cystic Fibrosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
CF ELF contained high levels of neutrophil elastase (NE) and various serine protease inhibitors prevented CF ELF from inducing IL-8 gene expression in BET-1A cells, suggesting that NE was the dominant inducer for IL-8 production in CF ELF.
|
1569186 |
1992 |
|
Cystic Fibrosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
There was also a clear association between CF ELF active NE and IL-8 levels (r = 0.94).
|
1357002 |
1992 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The result shows that tumor and cells of the surrounding reactive lesion express IL-8 genes, but it is not expressed in normal brains.
|
1407609 |
1992 |
|
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The role of other cytokines, such as interleukin-8 (IL-8), a neutrophil chemoattractant and activator, in the pathophysiology of human sepsis is not well characterized, and there are only limited data on IL-6.
|
1375198 |
1992 |
|
Sepsis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The role of other cytokines, such as interleukin-8 (IL-8), a neutrophil chemoattractant and activator, in the pathophysiology of human sepsis is not well characterized, and there are only limited data on IL-6.
|
1375198 |
1992 |
|
Stomach Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The production of IL-8 protein was detected by enzyme-linked immunosorbent assay in the culture supernatants derived from eight of nine human gastric cancer cell lines stimulated with either interleukin 1 alpha (IL-1 alpha), tumor necrosis factor alpha (TNF alpha), or TNF alpha plus interferon gamma (IFN gamma).
|
1331059 |
1992 |
|
Primary malignant neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
From these results, it is suspected that astroglial cell-derived IL-8 may take part in neutrophil-mediated inflammation which accompanies infection, degeneration and malignancy in the brain.
|
1407609 |
1992 |
|
Childhood Astrocytoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Primers for 9 different human lymphokines, from IL-1 alpha to IL-8, were used to analyze RNA transcripts in 5 cultured human astrocytoma cell lines and fresh brain specimens by PCR. mRNA transcripts for IL-8 were detected in all neuroglial cells.
|
1407609 |
1992 |
|
Chorioamnionitis
|
0.090 |
Biomarker
|
phenotype |
BEFREE |
Northern blot analysis of IL-8 mRNA expression demonstrated a constant level during pregnancy with or without chorioamnionitis, indicating the possibility that the major site of regulation of IL-8 synthesis in the placenta is posttranscriptional.
|
1391327 |
1992 |
|
Carcinoma, Transitional Cell
|
0.070 |
Biomarker
|
disease |
BEFREE |
In this report, the authors demonstrate that human transitional cell carcinomas and renal cell carcinomas have the capacity to elaborate IL-8 in response to the inflammatory mediators IL-1 beta and tumor necrosis factor (TNF)-alpha.
|
1739130 |
1992 |
|
Dermatitis
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
We analyzed interleukin 8 mRNA levels in more than a hundred epidermal samples from patients and normal test persons and found a variation over several orders of magnitude that seemed to follow the degree of inflammation of the skin.
|
1469297 |
1992 |
|
Fibrosarcoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Molecular analysis of the inhibition of interleukin-8 production by dexamethasone in a human fibrosarcoma cell line.
|
1592440 |
1992 |
|
Anaplastic thyroid carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
A neutrophil chemotactic factor (human interleukin 8, human granulocyte-macrophage colony-stimulating factor)-producing cell line, named KHM-5M, was established from a patient with an undifferentiated thyroid carcinoma, neutrophilia, and malignant pleurisy with many neutrophils and a few malignant cells.
|
1728417 |
1992 |
|
Adult Fibrosarcoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Molecular analysis of the inhibition of interleukin-8 production by dexamethasone in a human fibrosarcoma cell line.
|
1592440 |
1992 |
|
Intrauterine infection
|
0.020 |
Biomarker
|
disease |
BEFREE |
Human placenta constitutively produces interleukin-8 during pregnancy and enhances its production in intrauterine infection.
|
1391327 |
1992 |
|
Melioidosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We studied serial concentrations of TNF, IL-6 (involved in the acute-phase response), and IL-8 in plasma and leukocyte levels of mRNA for these cytokines in patients with localized and septicemic Pseudomonas pseudomallei infection on admission to the hospital and during a prolonged recovery phase (up to 30 days).
|
1375198 |
1992 |
|
Anaplastic astrocytoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In addition to the cultured cells, we examined IL-8 gene expression within human malignant astrocytoma, peritumoral brain and autopsied normal brains.
|
1407609 |
1992 |