|
Chronic Obstructive Airway Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In COPD PHLFs, the induction of miR-146a-5p was significantly less compared with controls and was associated with the SNP rs2910164 (GG allele) in the miR-146a-5p gene.Our results suggest that induction of miR-146a-5p is involved in epithelial-fibroblast communication in the lungs and negatively regulates epithelial-derived IL-1α induction of IL-8 by fibroblasts.
|
28546273 |
2017 |
|
Chronic Obstructive Airway Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Although IL-8 plays an important role in the chemotaxis of inflammatory cells, the polymorphisms investigated here do not seem to be involved in the genetic predisposition to COPD.
|
16007706 |
2005 |
|
Chronic Obstructive Airway Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
DHBE cells exhibit a dampened IL-8 release, indicating that COPD is associated with a reduced capacity of airway epithelial cells to respond to foreign material.
|
23499888 |
2013 |
|
Chronic Obstructive Airway Disease
|
0.400 |
Biomarker
|
disease |
CTD_human |
MicroRNA-218 acts by repressing TNFR1-mediated activation of NF-κB, which is involved in MUC5AC hyper-production and inflammation in smoking-induced bronchiolitis of COPD.
|
28864214 |
2017 |
|
Chronic Obstructive Airway Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Lung fibroblasts from Control (C) (n=6), Smoker (HS) (n=6) and COPD patients (n=8) were cultured, and basal PGE2, VEGF, and IL-8 measured in supernatants by ELISA.
|
26926362 |
2016 |
|
Chronic Obstructive Airway Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
For inflammatory cytokines, lncRNA ANRIL expression was negatively correlated with TNF-α (P < 0.001), IL-1β (P = 0.015), IL-8 (P = 0.008), IL-17A (P = 0.002), and LTB-4 (P = 0.004) in AECOPD patients, while it was negatively correlated with TNF-α (P = 0.049), IL-1β (P = 0.005), IL-17A (P = 0.030), and LTB-4 (P = 0.011) in stable COPD patients.
|
30230590 |
2019 |
|
Chronic Obstructive Airway Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Corticosteroid sensitivity was determined as the 50% inhibitory concentration of dexamethasone on tumor necrosis factor-α-induced interleukin-8 release in peripheral blood mononuclear cells from patients with COPD (n = 17) and compared with that of nonsmoking (n = 8) and smoking (n = 7) control subjects.
|
20224070 |
2010 |
|
Chronic Obstructive Airway Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
After 18 h of cell culture the basal release of MMP-9 was 2.5-fold, p < 0.02 greater, whereas IL-8 was 1.8-fold (p < 0.01) lower from COPD patient monocytes than from controls.
|
14624669 |
2003 |
|
Chronic Obstructive Airway Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Cigarette smoke dose-dependently induced apoptosis, proliferation and CXCL8 release with normal epithelial cells being more responsive than COPD patient derived cells.
|
28468623 |
2017 |
|
Chronic Obstructive Airway Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Fluticasone propionate (FP) and dexamethasone (DEX) suppressed IL-6 and IL-8 production in BEAS-2B cells, but clarithromycin (CAM) failed to do so.<b>Conclusions:</b><i>P. aeruginosa</i>-derived flagellin-induced IL-6 and IL-8 production in bronchial epithelial cells, which partially explains the mechanisms of progression and exacerbation of COPD.
|
31517562 |
2019 |
|
Chronic Obstructive Airway Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
The relationship between CCSP/IL8 concentration ratios in the supernatant of induced sputum from COPD patients <i>versus</i> neutrophilic airway infiltration assessed in lung biopsies was assessed.Increased neutrophilic chemotactic activity of CSE-treated ALI cultures followed IL8 concentrations and returned to normal when supplemented with rhCCSP. rhIL8-induced chemotaxis of neutrophils was reduced by rhCCSP. rhCCSP and rhIL8 co-immunoprecipitated.
|
31023848 |
2019 |
|
Chronic Obstructive Airway Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
ELISA assay showed hydrogen-rich saline lowered the levels of pro-inflammatory cytokines (IL-8 and IL-6) and anti-inflammatory cytokine IL-10 in bronchoalveolar lavage fluid and serum of chronic obstructive pulmonary disease rats.
|
28795606 |
2017 |
|
Chronic Obstructive Airway Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
COPD airway epithelial cells showed attenuated IL-8 responses to TLR2 agonist despite expressing TLR2 similar to normal, indicating dysregulation in TLR2 signaling pathway.
|
31548332 |
2019 |
|
Chronic Obstructive Airway Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
In conclusion, Epac and PKA decrease CSE-induced IL-8 release by human ASM cells via inhibition of NF-κB and ERK, respectively, pointing at these cAMP effectors as potential targets for anti-inflammatory therapy in COPD.
|
22363678 |
2012 |
|
Chronic Obstructive Airway Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
However, following active filtration, we only observed significant reductions on systemic inflammation measured as of IL-8 at 58.59% (95% CI: -76.31, -27.64) in the total group of participants and 70.04% (95% CI: -83.05, -47.05) in the subset of COPD patients, with adjustments.
|
28645052 |
2017 |
|
Chronic Obstructive Airway Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Statistical analyses revealed that changes in viral communities correlate most with changes in levels of arachidonic acid and IL-8, both potentially relevant for chronic obstructive pulmonary disease (COPD) pathogenesis based on prior studies.
|
30208886 |
2018 |
|
Chronic Obstructive Airway Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
In conclusion, our data indicate that CSE has both the potential to diminish anti-viral immunity by downregulating the release of IFN-alpha and other pro-inflammatory cytokines while, at the same time, augmenting the pathogenesis of COPD via an IL-8 induced recruitment of neutrophils.
|
19515231 |
2009 |
|
Chronic Obstructive Airway Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Moreover, the values of neutrophils (61.8%±15.1%), MPO (574.0±111.8 ng/mL), and IL-8 (32.6±13.4 ng/mL) in induced sputum in stable COPD patients with positive BD tests were significantly higher than those in asthmatics or normal controls (all P<0.01).
|
31346991 |
2019 |
|
Chronic Obstructive Airway Disease
|
0.400 |
Biomarker
|
disease |
CTD_human |
Decreased FoxO3A in COPD cells was associated with increased phosphorylation of EGFR, Akt and FoxO3A and treatment with quercetin, LY294002 or erlotinib increased nuclear FoxO3A and decreased IL-8 and phosphorylation of Akt, EGFR and FoxO3A, Compared with control, elastase/LPS-exposed mice showed decreased nuclear FoxO3A, increased chemokines and phosphorylation of EGFR and Akt.
|
23099361 |
2013 |
|
Chronic Obstructive Airway Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
LABAs and p38MAPK Inhibitors Reverse the Corticosteroid-Insensitivity of IL-8 in Airway Smooth Muscle Cells of COPD.
|
31766770 |
2019 |
|
Chronic Obstructive Airway Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
In comparison with the nonrespiratory surgical procedure and S-COPD groups, neutrophilia and gene expression for epithelial-derived neutrophil attractant-78 (CXCL5), interleukin-8 (CXCL8), CXCR1, and CXCR2 were each upregulated in the E-COPD group (p < 0.01); compared with the S-COPD group, by 97-, 6-, 6-, 3-, and 7-fold, respectively (p < 0.01).
|
12857718 |
2003 |
|
Chronic Obstructive Airway Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
The inflammatory chemokines interleukin-8, macrophage inflammatory protein-1alpha, and monocyte chemoattractant protein-1, are reportedly involved in the pathogenesis of chronic obstructive pulmonary disease (COPD).
|
15220136 |
2004 |
|
Chronic Obstructive Airway Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
IL-8-dependent inflammation is a hallmark of host lung innate immunity to bacterial pathogens, yet in many human lung diseases, including chronic obstructive pulmonary disease, bronchiectasis, and pulmonary fibrosis, there are progressive, irreversible, pathological changes associated with elevated levels of IL-8 in the lung.
|
29894204 |
2018 |
|
Chronic Obstructive Airway Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
In contrast, roflumilast showed similar inhibitory effects on IL-8 release in healthy (58.8%), smokers (56.6%) and smokers with COPD (50.5%).
|
25652132 |
2015 |
|
Chronic Obstructive Airway Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
This study suggests that polymorphisms in both CSF2 and IL8 may play a role in the pathogenesis of COPD, at least in highly exposed populations.
|
17681858 |
2008 |