Chronic Obstructive Airway Disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Significant correlations were found between VEGF levels and pack years (r = 0.56, p = 0.046), IL-8 (r = 0.64, p = 0.026) and TNF-alpha (r = 0.62, p = 0.031) levels both in asymptomatic and COPD smokers (r = 0.66, p = 0.027, r = 0.67, p = 0.023, and r = 0.82, p = 0.002, respectively).
|
17631682 |
2007 |
Chronic Obstructive Airway Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
DHBE cells exhibit a dampened IL-8 release, indicating that COPD is associated with a reduced capacity of airway epithelial cells to respond to foreign material.
|
23499888 |
2013 |
Chronic Obstructive Airway Disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The cell response was evaluated by measuring the expression of IL-8 and IL-10, respectively, pro- and anti-inflammatory cytokines involved in COPD pathogenesis, as well as of pertinent TLR-4 pathway mediators.
|
28976240 |
2017 |
Chronic Obstructive Airway Disease
|
0.400 |
Biomarker
|
disease |
CTD_human |
MicroRNA-218 acts by repressing TNFR1-mediated activation of NF-κB, which is involved in MUC5AC hyper-production and inflammation in smoking-induced bronchiolitis of COPD.
|
28864214 |
2017 |
Chronic Obstructive Airway Disease
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
Cigarette smoke is the leading risk factor for the development of chronic obstructive pulmonary disease (COPD) an inflammatory condition characterised by neutrophilic inflammation and release of proinflammatory mediators such as interleukin-8 (IL-8).
|
16029496 |
2005 |
Chronic Obstructive Airway Disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
COPD patients had higher interleukin (IL)-1 and IL-8 mRNA expression levels, and these inflammatory cytokines positively correlate with MDA-5 levels.
|
24992168 |
2016 |
Chronic Obstructive Airway Disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Gene expression analysis showed that CSE suppressed LPS-induced TNF-α transcription but not CXCL8 transcription in COPD alveolar macrophages.
|
24528166 |
2014 |
Chronic Obstructive Airway Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Lung fibroblasts from Control (C) (n=6), Smoker (HS) (n=6) and COPD patients (n=8) were cultured, and basal PGE2, VEGF, and IL-8 measured in supernatants by ELISA.
|
26926362 |
2016 |
Chronic Obstructive Airway Disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In addition, mediators that are regulated by the A(2B)R, such as IL-6, IL-8 and osteopontin were elevated in these samples and activation of the A(2B)R on cells isolated from the airways of COPD and IPF patients was shown to directly induce the production of these mediators.
|
20169073 |
2010 |
Chronic Obstructive Airway Disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
IL-10 disrupts the Brd4-docking sites to inhibit LPS-induced CXCL8 and TNF-α expression in monocytes: Implications for chronic obstructive pulmonary disease.
|
26044852 |
2015 |
Chronic Obstructive Airway Disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In order to assess the relation of IL-18 with pulmonary function and airway inflammation in COPD, IL-18, tumour necrosis factor-alpha, and IL-8 levels were measured by ELISA in sputum supernatants obtained from patients with bronchitis type COPD (n=28), and healthy subjects (18 smokers and 17 non-smokers).
|
19208460 |
2009 |
Chronic Obstructive Airway Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
For inflammatory cytokines, lncRNA ANRIL expression was negatively correlated with TNF-α (P < 0.001), IL-1β (P = 0.015), IL-8 (P = 0.008), IL-17A (P = 0.002), and LTB-4 (P = 0.004) in AECOPD patients, while it was negatively correlated with TNF-α (P = 0.049), IL-1β (P = 0.005), IL-17A (P = 0.030), and LTB-4 (P = 0.011) in stable COPD patients.
|
30230590 |
2019 |
Chronic Obstructive Airway Disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Specimens of lung tissue obtained from patients with increasing clinical stages of COPD had graded reductions in HDAC activity and increases in interleukin-8 messenger RNA (mRNA) and histone-4 acetylation at the interleukin-8 promoter.
|
15888697 |
2005 |
Chronic Obstructive Airway Disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Both miR-34c-5p agomir and CCL22 shRNA could reduce breathing frequency (f), airway resistance (RI), and the levels of IL-8 and TNF-α in BALF of COPD rats with increased Cydn (dynamic lung compliance) and PIF (peak inspiratory flow).
|
31032652 |
2020 |
Chronic Obstructive Airway Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Corticosteroid sensitivity was determined as the 50% inhibitory concentration of dexamethasone on tumor necrosis factor-α-induced interleukin-8 release in peripheral blood mononuclear cells from patients with COPD (n = 17) and compared with that of nonsmoking (n = 8) and smoking (n = 7) control subjects.
|
20224070 |
2010 |
Chronic Obstructive Airway Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
After 18 h of cell culture the basal release of MMP-9 was 2.5-fold, p < 0.02 greater, whereas IL-8 was 1.8-fold (p < 0.01) lower from COPD patient monocytes than from controls.
|
14624669 |
2003 |
Chronic Obstructive Airway Disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Interestingly, MCP-1 level was higher only in COPD-E versus CSs and CNSs; EGF and IL-8 levels were higher in COPD-B and COPD-E versus CNSs; IL-6 level was increased in all three smoking groups (COPD-B, COPD-E, and CSs) versus CNS; IFN-γ and IL-1α levels were higher in CSs than in CNSs; and IL-1α level was also higher in CSs versus COPD-B and COPD-E.
|
29872287 |
2018 |
Chronic Obstructive Airway Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Cigarette smoke dose-dependently induced apoptosis, proliferation and CXCL8 release with normal epithelial cells being more responsive than COPD patient derived cells.
|
28468623 |
2017 |
Chronic Obstructive Airway Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Fluticasone propionate (FP) and dexamethasone (DEX) suppressed IL-6 and IL-8 production in BEAS-2B cells, but clarithromycin (CAM) failed to do so.<b>Conclusions:</b><i>P. aeruginosa</i>-derived flagellin-induced IL-6 and IL-8 production in bronchial epithelial cells, which partially explains the mechanisms of progression and exacerbation of COPD.
|
31517562 |
2019 |
Chronic Obstructive Airway Disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
BRD4 is increased in the lung of patients with COPD and is correlated with miR-29b and IL-8 expression. miR-29b regulates cigarette smoke extract (CSE)-induced IL-8 expression by targeting BRD4 in HBE cells.
|
30652495 |
2019 |
Chronic Obstructive Airway Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
The relationship between CCSP/IL8 concentration ratios in the supernatant of induced sputum from COPD patients <i>versus</i> neutrophilic airway infiltration assessed in lung biopsies was assessed.Increased neutrophilic chemotactic activity of CSE-treated ALI cultures followed IL8 concentrations and returned to normal when supplemented with rhCCSP. rhIL8-induced chemotaxis of neutrophils was reduced by rhCCSP. rhCCSP and rhIL8 co-immunoprecipitated.
|
31023848 |
2019 |
Chronic Obstructive Airway Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
ELISA assay showed hydrogen-rich saline lowered the levels of pro-inflammatory cytokines (IL-8 and IL-6) and anti-inflammatory cytokine IL-10 in bronchoalveolar lavage fluid and serum of chronic obstructive pulmonary disease rats.
|
28795606 |
2017 |
Chronic Obstructive Airway Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
COPD airway epithelial cells showed attenuated IL-8 responses to TLR2 agonist despite expressing TLR2 similar to normal, indicating dysregulation in TLR2 signaling pathway.
|
31548332 |
2019 |
Chronic Obstructive Airway Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
In conclusion, Epac and PKA decrease CSE-induced IL-8 release by human ASM cells via inhibition of NF-κB and ERK, respectively, pointing at these cAMP effectors as potential targets for anti-inflammatory therapy in COPD.
|
22363678 |
2012 |
Chronic Obstructive Airway Disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In the Jinwei Tang + budesonide and theophylline + budesonide groups, IL-8 and TNF-α expression was significantly decreased (P<0.05) and the HDAC2 level increased (P<0.05) compared with that in the COPD group.
|
29456664 |
2018 |