|
Malignant pleurisy
|
0.010 |
Biomarker
|
disease |
BEFREE |
A neutrophil chemotactic factor (human interleukin 8, human granulocyte-macrophage colony-stimulating factor)-producing cell line, named KHM-5M, was established from a patient with an undifferentiated thyroid carcinoma, neutrophilia, and malignant pleurisy with many neutrophils and a few malignant cells.
|
1728417 |
1992 |
|
Rheumatoid Arthritis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Levels of MCP-1 were significantly correlated with levels of IL-1 beta, IL-6, and IL-8 in the culture supernatants of synovia from RA.
|
8403545 |
1993 |
|
Rheumatoid Arthritis
|
0.400 |
Biomarker
|
disease |
BEFREE |
These studies demonstrate that by expressing the chemokines RANTES and IL-8, synovial fibroblasts may participate in the ongoing inflammatory process in rheumatoid arthritis.
|
7680648 |
1993 |
|
Leukemia, Myelocytic, Acute
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We examined expression of IL-8 and its receptor in purified leukemic cells from patients with untreated acute myeloblastic leukemia (AML) and lymphoid leukemias.
|
8400299 |
1993 |
|
Leukemia, Myelocytic, Acute
|
0.100 |
Biomarker
|
disease |
BEFREE |
Since IL-8 displays a wide range of biological activities, including the regulation of some membrane molecules relevant to adhesion and migration processes, its production by AML blasts might be of relevance for the pattern of leukemic growth.
|
8412317 |
1993 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, they suggest that IL-8 may play a role not only in immunomodulation but also in melanoma progression and metastatic spread.
|
8360485 |
1993 |
|
Psoriasis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our data suggest that in psoriatic skin, elevated IL-8 levels and markedly increased IL-8R expression may act in concert to induce the cardinal signs of psoriasis--epidermal hyperproliferation and leukocyte infiltration.
|
7691948 |
1993 |
|
Hepatitis B
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
The interleukin-8 promoter is transcriptionally activated by interleukin-1, tumor necrosis factor alpha, phorbol myristate acetate, or hepatitis B virus X protein through a sequence located between positions -91 and -71.
|
8413306 |
1993 |
|
MYELODYSPLASTIC SYNDROME
|
0.060 |
AlteredExpression
|
group |
BEFREE |
LPS-induced IL-6 and IL-8 expression of two patients with MDS were significantly higher than normal.
|
7522519 |
1993 |
|
Psoriasis vulgaris
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Because psoriasis vulgaris is characterized by epidermal hyperproliferation and infiltration of inflammatory cells, we investigated the expression of IL-8 and its receptor in normal and psoriatic epidermis using semiquantitative reverse-transcriptase-polymerase chain reaction.
|
7691948 |
1993 |
|
Aplastic Anemia
|
0.020 |
Biomarker
|
disease |
BEFREE |
We studied mRNA expression of the cytokine granulocyte-colony stimulating factor (G-CSF), interleukin-1 beta (IL-1 beta), IL-6, IL-8 and stem cell factor of stromal cells derived from bone marrows of nine normal volunteers, eight patients with aplastic anaemia (AA) and seven patients with myelodysplastic syndrome (MDS).
|
7522519 |
1993 |
|
Chronic granulomatous disease
|
0.020 |
Biomarker
|
group |
BEFREE |
To determine whether NADPH-oxidase-generated free radicals were critical in the regulation of IL-8, studies were performed using blood from patients with chronic granulomatous disease.
|
8244994 |
1993 |
|
Lymphoid leukemia
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Constitutive expression of interleukin-8 and its receptor in human myeloid and lymphoid leukemia.
|
8400299 |
1993 |
|
Myeloid Leukemia, Chronic
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
A significant reduction of both secretion of IL-8 protein and accumulation of IL-8 mRNA in vitro was observed in several cell types comprising peripheral blood mononuclear cells (PBMNC) from healthy donors and from patients with chronic myelogenous leukemia (CML), the myelomonocytic cell line THP-1, and bone marrow (BM) stromal cells as a representative model for BM microenvironment.
|
8400288 |
1993 |
|
Giant cell carcinoma of lung
|
0.020 |
Biomarker
|
disease |
BEFREE |
The N terminus of CT/IL-8 was AVLPR-SAKELRXQXIKTYSK- - -, the same as that of LUCT/IL-8, which is constitutively secreted from lung giant cell carcinoma LU65C cells.
|
8344717 |
1993 |
|
Primary systemic vasculitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
In extension of earlier reports, we detected an overexpression of transforming growth factor beta (TGF beta), interleukin 6 (IL6), and interleukin 8 (IL8), indicating that the whole cytokine cascade is activated to a significant extent in PSV.
|
8296631 |
1993 |
|
Mucocutaneous leishmaniasis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The message for interferon-gamma (IFN-gamma), tumour necrosis factor-beta (TNF-beta), and IL-8 was expressed in the three clinical forms of ACL.
|
8443970 |
1993 |
|
American cutaneous leishmaniasis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The message for interferon-gamma (IFN-gamma), tumour necrosis factor-beta (TNF-beta), and IL-8 was expressed in the three clinical forms of ACL.
|
8443970 |
1993 |
|
Rheumatoid Arthritis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We found evidence that the IL-10 expression was functionally relevant, as neutralization of endogenously produced IL-10 in the RA synovial membrane cultures resulted in a two- to threefold increase in the protein levels of proinflammatory cytokines tumor necrosis factor alpha (TNF-alpha) and IL-1 beta, although IL-6 and IL-8 levels were not affected.
|
8163935 |
1994 |
|
Rheumatoid Arthritis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Synovial fluid aspirated from 34 patients with symptomatic rheumatoid arthritis (RA) was evaluated for the presence of human cytomegalovirus (CMV) genomic material using polymerase chain reaction (PCR), and for levels of interleukin 8 (IL-8) and IL-6 using enzyme-linked immunoadsorbence assay.
|
7948616 |
1994 |
|
Rheumatoid Arthritis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Since IL-8 has a proinflammatory action whereas IL-1ra is antiinflammatory, our objective was to examine the relative levels of production of these cytokines by synovial fluid (SF) neutrophils isolated from patients with rheumatoid arthritis (RA).
|
8003057 |
1994 |
|
Ulcerative Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
In accordance with the characteristic histological signs of active disease, IL-8-expressing cells were diffusely distributed over the entire affected mucosa in patients with ulcerative colitis, whereas in patients with Crohn's disease, IL-8-expressing cells showed a focal distribution pattern.
|
8178948 |
1994 |
|
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
A glucocorticoid, dexamethasone, inhibited the production of a leukocyte chemotactic cytokine, interleukin 8 (IL-8), as well as mRNA expression by a glioblastoma cell line, T98G, stimulated with interleukin 1 (IL-1).
|
8175759 |
1994 |
|
Glioblastoma Multiforme
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
A glucocorticoid, dexamethasone, inhibited the production of a leukocyte chemotactic cytokine, interleukin 8 (IL-8), as well as mRNA expression by a glioblastoma cell line, T98G, stimulated with interleukin 1 (IL-1).
|
8175759 |
1994 |
|
Malignant tumor of colon
|
0.100 |
Biomarker
|
disease |
BEFREE |
We consistently failed to detect IL-8 messenger RNA in the mucosa of uninvolved bowel segments and in normal-appearing control mucosa of patients with colon cancer.
|
8178948 |
1994 |