Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Interleukin-8 (IL-8, CXCL8) is an inflammatory factor, known to play an important role in the development of atherosclerosis.
|
31124391 |
2019 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study investigated the value of using ultrasound-targeted microbubble destruction (UTMD) to deliver an IL-8 monoclonal antibody to inhibit the inflammatory response and increase plaque stability in a rabbit model of atherosclerosis (AS).
|
31545223 |
2019 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our studies suggest that the IL-8-miR-183-ABCA1 axis may play an intermediary role in the development of atherosclerosis.
|
29703573 |
2019 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
IL-8 interacted with its receptor CXC chemokine receptor 2 (CXCR2) on neutrophils, leading to the formation of NETs via Src and extracellular signal-regulated kinase (ERK) and p38 mitogen-activated protein kinases (MAPK) signaling to aggravate AS progression <i>in vivo</i>.
|
31496351 |
2019 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
TNF-α correlated with steatosis (p < 0.001) and HOMA-IR (p < 0.03), whereas IL8 correlated with steatosis (p = <0.001), TNF-α (p < 0.04) and atherosclerosis (p < 0.01).
|
30066228 |
2018 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The present study demonstrates that IL-33 induces IL-8 expression via JNK/c-Jun/AP-1 pathway in human vascular endothelial cells, and provides a new insight into the role of IL-33-induced IL-8 in the pathophysiology of atherosclerosis and vascular inflammation.
|
29373608 |
2018 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Interleukin-8 (IL-8) is a chemokine involved in systemic immunity, macrophages infiltration and activation in adipose tissue and may play a significant role in the pathogenesis of type 2 diabetes (T2D) and atherosclerosis.
|
28836077 |
2017 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Inhibition of IL-8-mediated endothelial adhesion, VSMCs proliferation and migration by siRNA-TMEM98 suggests TMEM98's emerging role in atherosclerosis.
|
29152140 |
2017 |
Arteriosclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Here, we further compare the role of <i>P. gingivalis</i> cells and their vesicles in expression of chemoattractant proteins including CXCL1, CXCL2, and CXCL8, and adhesive molecules such as E-selectin in human umbilical vein endothelial cells (HUVECs).Both <i>P. gingivalis</i> 33277 cells and vesicles were able to up-regulate expression of these molecules, while the vesicles acted as more potent inducers of the inflammatory response associated with the development of atherosclerosis, consequently resulting in significant monocyte adhesion to a monolayer of HUVECs.
|
27826542 |
2016 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The purpose of our study was to investigate the effects of endothelial lipase gene polymorphism and inflammation markers (CRP, IL-1β, IL-6, IL-8 and TNF-α) in the atherosclerosis.
|
23673478 |
2013 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Interferon regulator factor 1/retinoic inducible gene I (IRF1/RIG-I) axis mediates 25-hydroxycholesterol-induced interleukin-8 production in atherosclerosis.
|
21979142 |
2012 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The Interleukin 8 (IL-8) response of endothelial cells to lipoproteins has well known implications for the development and progression of atherosclerosis.
|
21310414 |
2011 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Exposure of ApoE-/- mice to TCDD caused a time-dependent progression of atherosclerosis, which was associated with induction of inflammatory genes, including interleukin-8, as well as F4/80 and matrix metalloproteinase-12.
|
21441140 |
2011 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, inhibition of TLR4 expression may downregulate the NF-kappa B activity and secretions of MCP-1 and IL-8 in monocytes due to oxidized LDL, resulting in the alleviation of the progress of atherosclerosis.
|
20467793 |
2010 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Interleukin-8 is a strong mediator of inflammation and has been implicated in the biochemical pathways involved in a wide range of inflammatory diseases including atherosclerosis.
|
19404719 |
2010 |
Arteriosclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Taken together, these data demonstrate an important role for the JAK2/STAT3 pathway in Ox-PAPC-induced IL-8 transcription in vitro and in atherosclerosis in vivo.
|
17726017 |
2007 |
Arteriosclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Validation by real-time polymerase chain reaction was undertaken with 2 genes known to be up-regulated in atherosclerosis (interleukin 1beta [IL-1beta] and IL-8) and 2 novel genes identified by the array analysis (signal transducer and activator of transcription 6 [STAT6] and IL-1 receptor-associated kinase [IRAK]).
|
16169330 |
2005 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Circulating IL-8 is increased in obese compared with lean subjects and is associated with measures of insulin resistance, development of atherosclerosis, and cardiovascular disease.
|
13129857 |
2004 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results in our study suggest that aspirin inhibits TNF-alpha stimulated MCP-1 and IL-8 release in HUVECs, for its additional therapeutic effects of aspirin in causing atherosclerosis.
|
15136050 |
2004 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thus, hypoxia in atherosclerotic plaques may increase the secretion of IL-8 from oxysterol-containing foam cells, which subsequently may accelerate the progression of atherosclerosis.
|
14612204 |
2003 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
CTGF, IL-8) whose responsiveness to shear stress had not been demonstrated, other known genes whose relationship to atherosclerosis had not been reported, and novel genes.
|
11996952 |
2002 |
Arteriosclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Therefore, we sought to determine whether IL-8 plays a role in mediating angiogenic activity in atherosclerosis.
|
10747344 |
2000 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The chemoattractant and/or mitogenic effects of IL-8 on neutrophils, T cells, smooth muscle, or vascular endothelial cells may contribute to the progression and complications of atherosclerosis.
|
8621523 |
1996 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The presence of IL-6 and IL-8 in the arterial wall where complement activation also occurred, clearly show the involvement of inflammatory events in initiation and progression of atherosclerosis.
|
9125317 |
1996 |