CXCL8, C-X-C motif chemokine ligand 8, 3576

N. diseases: 1254; N. variants: 10
Disease: Cachexia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0006625
Disease: Cachexia
Cachexia 		0.360 Biomarker phenotype BEFREE However, shRNA knockdown of the IL-8 gene did not suppress tumor growth and cachexia in the AkuNEC model, indicating that IL-8 is not directly involved in cachexia induction. 31069007 2019
CUI: C0006625
Disease: Cachexia
Cachexia 		0.360 Biomarker phenotype BEFREE Also, IL-8 was positively correlated with weight loss in cachectic patients (P = 0.04; r = 0.627). 31273954 2019
CUI: C0006625
Disease: Cachexia
Cachexia 		0.360 Biomarker phenotype BEFREE Elevated Serum Interleukin-8 Level Correlates with Cancer-Related Cachexia and Sarcopenia: An Indicator for Pancreatic Cancer Outcomes. 30513776 2018
CUI: C0006625
Disease: Cachexia
Cachexia 		0.360 GeneticVariation phenotype BEFREE These results suggest that the genetic polymorphisms of proinflammatory cytokine IL-8 may contribute to the pathogenesis of cachexia in gastric cancer patients. 19929572 2010
CUI: C0006625
Disease: Cachexia
Cachexia 		0.360 AlteredExpression phenotype BEFREE The expression of the IL-8 gene was also elevated in cachexia inducing xenografts (CIX). 17878525 2007
CUI: C0006625
Disease: Cachexia
Cachexia 		0.360 Biomarker phenotype LHGDN Impact of weight loss on circulating IL-1, IL-6, IL-8, TNF-alpha, VEGF-A, VEGF-C and midkine in gastroesophageal cancer patients. 17931612 2007
CUI: C0006625
Disease: Cachexia
Cachexia 		0.360 Biomarker phenotype CTD_human Molecular analysis of xenograft models of human cancer cachexia--possibilities for therapeutic intervention. 17878525 2007