|
Gastritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
CXC Chemokine Ligand 8 (CXCL8) plays an important role in gastric inflammation and in the progression of gastric cancer induced by Helicobacter pylori (H. pylori) infection.
|
31522447 |
2019 |
|
Gastritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The number of Th17 cells and the expression of IL-8 and IL-17A in infected patients with peptic ulcer were significantly higher than patients with gastritis.
|
29481961 |
2018 |
|
Gastritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Release of IL-8 by the stomach epithelium is a hallmark of gastritis and contributes to the amplification of the inflammatory state.
|
29928974 |
2018 |
|
Gastritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Strawberry tannins inhibit IL-8 secretion in a cell model of gastric inflammation.
|
27473819 |
2016 |
|
Gastritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our findings suggest that PFS containing water extracts from Vitis vinifera L. leaves could be useful to inhibit/attenuate gastric inflammation inhibiting IL-8 secretion and expression through impairment of the NF-κB pathway.
|
26102216 |
2015 |
|
Gastritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
IL-8 was strongly up-regulated on systemic or local inflammatory stimulation, increasing mobilization of immature CD11b(+)Gr-1(+) myeloid cells (IMCs) with thioglycolate-induced peritonitis, DSS-induced colitis, and H. felis-induced gastritis.
|
23041326 |
2013 |
|
Gastritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
We used four different H. pylori strains isolated from patients with gastritis or duodenal ulcer disease to examine their differential effects on signaling pathways and IL-8 gene response in gastric epithelial cells.
|
20886283 |
2011 |
|
Gastritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The IL-8 and IL-1beta levels decrease significantly from chronic gastritis to gastric cancer, while the relative expression remained unaltered when COX-2 expression was analyzed among patients with gastritis and cancer.
|
18985541 |
2009 |
|
Gastritis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In the case of T-251A of IL-8, the frequency of the A/A genotype was significantly increased in gastritis (P=0.049) and IM (P=0.038) groups as compared with the histologically negative ones.
|
18301299 |
2008 |
|
Gastritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In this study, only gastritis was found to be associated with significant oxidative stress marker expression of TNF-alpha and IL-8 that was also related to H. pylori virulence, suggesting that they are the main oxidant stress markers responsible to trigger an increase in ROS level that contributes to decrease the expression of the MnSOD and GPX.
|
17466292 |
2007 |
|
Gastritis
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
The IL-8 heterozygote mutant variant was detected with a significantly higher frequency among the DU patients and those with gastritis than among the H. pylori-positive controls.
|
17309748 |
2007 |
|
Gastritis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The IL-8 heterozygote mutant variant was detected with a significantly higher frequency among the DU patients and those with gastritis than among the H. pylori-positive controls.
|
17309748 |
2007 |
|
Gastritis
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
These results might explain the clinical studies in which patients with duodenal ulcers had higher levels of IL-8 in the antral gastric mucosa than patients with simple H. pylori gastritis.
|
17517062 |
2007 |
|
Gastritis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The IL-8 -251 A/T polymorphism and the polymorphisms in H pylori vacA gene are involved in limiting the infection outcome to gastritis and peptic ulcer or in favoring cancer onset in Iranian patients.
|
16937534 |
2006 |
|
Gastritis
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
The IL-8 -251 A/T polymorphism and the polymorphisms in H pylori vacA gene are involved in limiting the infection outcome to gastritis and peptic ulcer or in favoring cancer onset in Iranian patients.
|
16937534 |
2006 |
|
Gastritis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We investigated the effects of an interleukin 8 (IL-8) gene polymorphism on the risk of gastroduodenal diseases, the degree of H pylori induced gastritis, and IL-8 gene transcription.
|
15710978 |
2005 |
|
Gastritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Its presence was also associated with more intense antral neutrophil infiltration and IL-8 levels and was a marker for protection against gastric atrophy, intestinal metaplasia, and gastric cancer (OR for gastric cancer = 0.42, 95% CI: 0.2-0.9 compared with gastritis).
|
15825067 |
2005 |
|
Gastritis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We also investigated the effect of the IL-8 polymorphism on IL-8 production and histologic degree of gastritis in noncancerous gastric mucosa.
|
16284368 |
2005 |
|
Gastritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results indicate that in mice and piglets (i) neither the cag PAI nor the ability to induce IL-8 in vitro is essential for colonization or neutrophilic inflammation and (ii) there is no direct relationship between the presence of the cag PAI, IL-8 induction, and neutrophilic gastritis.
|
11292705 |
2001 |
|
Gastritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In contrast to earlier findings with IL-8, the degree of ENA-78 mRNA upregulation was independent of the grade of activity of gastritis.
|
11119492 |
2001 |
|
Gastritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Partial and complete disruption of the cag island in strain B128 attenuated induction of IL-8 in vitro and significantly decreased gastric inflammation in vivo.
|
11238562 |
2001 |
|
Gastritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Gastritis activity significantly correlated with cag (p<0.05) and Interleukin-8 expression (p<0.005].
|
11057919 |
2001 |
|
Gastritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
IL-8 levels were higher in patients with atrophic gastritis than in patients with nonatrophic gastritis (p < 0.05).
|
10927930 |
2000 |
|
Gastritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
IL-1beta and IL-8 levels in the antrum were greater in DU than in gastritis; in the corpus the cytokine level/H pylori differed irrespective of similar H pylori densities.
|
10562576 |
1999 |
|
Gastritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
To investigate possible associations between mucosal-specific IgA, the toxinogenicity of H. pylori, mucosal levels of IL-8 and gastric inflammation, 52 endoscoped patients were studied.
|
10087249 |
1999 |