|
Lung diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Therefore, we sought to determine the importance of the neutrophil chemotactic cytokine interleukin-8 (IL-8) in DA-induced lung disease using in vivo and in vitro model systems.
|
30851105 |
2019 |
|
Lung diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Association among blood BPDE-DNA adduct, serum interleukin-8 (IL-8) and DNA strand breaks for children with pulmonary diseases.
|
31722538 |
2019 |
|
Lung diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
<i>Pseudomonas</i> on BAL was associated with positive neutrophil elastase (OR 4.17, 95% CI 2.04-8.53; p<0.001), increased interleukin-8 (p<0.001), increased all baseline PRAGMA computed tomography scores (p<0.001), progression of PRAGMA computed tomography scores (p<0.05) and increased risk of respiratory exacerbations (incidence rate ratio 2.11, 95% CI 1.15-3.87; p=0.017).In children with CF OPSs only marginally change the probability of detecting lower airway <i>Pseudomonas</i> and are not associated with lung disease indices nor exacerbations risk.
|
29678944 |
2018 |
|
Lung diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
IL-8-dependent inflammation is a hallmark of host lung innate immunity to bacterial pathogens, yet in many human lung diseases, including chronic obstructive pulmonary disease, bronchiectasis, and pulmonary fibrosis, there are progressive, irreversible, pathological changes associated with elevated levels of IL-8 in the lung.
|
29894204 |
2018 |
|
Lung diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
The concentrations of TNF-α and CXCL8, but not others, were negatively correlated with severity of disease (lung function forced expiratory volume in 1 s) (TNF-α vs. total: r = -0.359, P= 0.002 vs. moderate/severe: r= -0.541, P= 0.001; CXCL8 vs. total: r = -0.327, P= 0.006 vs. moderate/severe: r = -0.625, P= 0.0001, respectively).
|
28836545 |
2017 |
|
Lung diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
The clinical importance of these chemokines was validated by association of CXCL1 and IL8 polymorphisms with changes in lung disease severity in patients with CF (n = 6365; IL8, P = .001; CXCL1, P = .001), confirming that targeting these chemokine pathways could help improve lung disease.
|
27799352 |
2017 |
|
Lung diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Strategies to inhibit aberrantly high CXCL8 expression hold therapeutic potential for CF lung disease.
|
26140537 |
2015 |
|
Lung diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Pro-inflammatory alleles of three cytokine genotypes, IL-8, IL-10 and IL-1β, appear to be associated with slightly more severe lung disease in patients with CF over a 13 year period.
|
24853301 |
2014 |
|
Lung diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Assessing the relationship between TGF β 1, IL-8, and TNF- α and lung disease in CF in an exacerbation-free interval.
|
24062613 |
2013 |
|
Lung diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Inflammatory mediators especially IL-8 and IL-6 play the primary role in the various chronic pulmonary diseases.
|
19748599 |
2009 |
|
Lung diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Variants in three inflammatory genes showed significant genotypic associations with CF lung disease severity, including IL8 and previously reported TGFbeta1 (P< or =0.05).
|
18563170 |
2008 |
|
Lung diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
We tested 13 polymorphisms in 8 genes that play a key role in the inflammatory response: tumor necrosis factor, lymphotoxin alpha, interleukin (IL) 1B, IL1 receptor antagonist, IL6, IL8, IL10 and transforming growth factor beta 1 (TGFB1), for an association with lung disease progression and nutritional status in 329 CF patients.
|
19009622 |
2008 |
|
Lung diseases
|
0.100 |
GeneticVariation
|
group |
LHGDN |
Variants in three inflammatory genes showed significant genotypic associations with CF lung disease severity, including IL8 and previously reported TGFbeta1 (P< or =0.05).
|
18563170 |
2008 |
|
Lung diseases
|
0.100 |
AlteredExpression
|
group |
LHGDN |
Correlation of augmented IL-8 production to premature chronic lung disease: implication of posttranscriptional regulation.
|
16085794 |
2005 |
|
Lung diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Interleukin-8 (IL-8) is considered as the major polymorphonuclear neutrophils (PMNs) chemoattractant cytokine in lung diseases such as asthma and adult respiratory distress syndrome (ARDS).
|
11269653 |
2001 |