Degenerative polyarthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Slice preparation and culturing activated numerous pathways across all PCTS, especially those involved in inflammation (IL-6, IL-8 and HMGB1 signalling) and tissue remodelling (osteoarthritis pathway and integrin signalling).
|
31754732 |
2019 |
Degenerative polyarthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The inflammatory pattern was assessed by RT-qPCR and ELISA (interleukin 6 (IL-6), IL-8, Cox2, and prostaglandin E2 (PGE<sub>2</sub>)) after a 24-h stimulation by IL-1β (1 ng/mL) and by conditioned medium from OA synovium.
|
31775901 |
2019 |
Degenerative polyarthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Gain- and loss-of-function studies revealed that FoxC1 overexpression promoted, whilst silencing inhibited OA synovial fibroblast (OASF) proliferation and pro-inflammatory cytokine (interleukin 6 (IL-6), interleukin 8 (IL-8), and tumour necrosis factor-α (TNF-α)) production.
|
31837247 |
2019 |
Degenerative polyarthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
When stimulated with FFA, osteoblasts from RA and OA patients secreted higher amounts of the proinflammatory cytokine interleukin (IL)-6 and the chemokines IL-8, growth-related oncogene α, and monocyte chemotactic protein 1.
|
31849953 |
2019 |
Degenerative polyarthritis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The purpose of the present case-control study was to investigate a possible association of four cytokine single nucleotide polymorphisms (SNPs), IL-4R -3223C>T (rs2057768), IL-8 -251T>A (rs4073), IL-10 -1082A>G (rs1800896) and TNF -A-308G>A (rs1800629) with OA susceptibility.
|
30186498 |
2018 |
Degenerative polyarthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The results indicated that the inflammatory factors TNF-α, interleukin (IL)-1β, IL-17a and IL-8 were upregulated in synovial fibroblasts taken from rats with osteoarthritis compared with normal rats.
|
30542428 |
2018 |
Degenerative polyarthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The levels of interleukin (IL) 6, tumor necrosis factor (TNF)α, IL-1β and IL-8 were significantly suppressed following MB treatment, indicating that MB protects against OA progression.
|
29581742 |
2018 |
Degenerative polyarthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, prednisone, ibuprofen and betamethasone may prevent OA by suppressing the expression of IL‑6 and IL‑8, subsequently inactivating NF‑κB and STAT3 pathways, and ultimately, leading to decreased levels of collagen I, MMP‑1, and MMP‑13.
|
28035387 |
2017 |
Degenerative polyarthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, chemokine (C-X-C motif) ligand-8 (CXCL8; chemoattractant), interleukin-6 (IL6) and chemokine (C-C motif) ligand 2 (CCL2) were elevated in the MSC-secretome in response to early- vs late-stage OA SF.
|
27894935 |
2017 |
Degenerative polyarthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
When the rats with OA were injected with miR‑27 lentiviral overexpression vector, the results of ELISA revealed that the levels of interleukin (IL)-6 and IL-8 were decreased.
|
28627582 |
2017 |
Degenerative polyarthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
We revealed that the expression of osteopontin (OPN), which has been reported to regulate expression of various inflammatory factors associating with the pathogenesis of OA including matrix metalloprotease 13 (MMP13), interlukine-6 and 8 (IL-6 and IL-8), is significantly upregulated in OA tissues.
|
28379604 |
2017 |
Degenerative polyarthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
IL-1β reduced PRG4 expression in OA synoviocytes and rhPRG4 (100 μg/ml) treatment reversed this effect (p < 0.001). rhPRG4 (200 μg/ml) reduced basal gene expression of MMP-1, MMP-3, MMP-13, IL-6, IL-8, and PRG4 in OA synoviocytes, while increasing TIMP-2 and cycloxygenase-2 (COX2) expression (p < 0.001). rhPRG4 (200 μg/ml) reduced IL-1β induction of MMP-1, MMP-3, MMP-9, MMP-13, IL-6, IL-8, and COX2 expression in a CD44-dependent manner (p < 0.001).
|
28482921 |
2017 |
Degenerative polyarthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Levels of IL-6 and IL-8 were also higher for RA-FLS, compared to healthy and OA FLS.
|
27072520 |
2016 |
Degenerative polyarthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The presence of -9 bp genotype is associated with higher TNF-α, IL-6, and IL-8 levels and higher TLR-2 expression in OA patients.
|
26982743 |
2016 |
Degenerative polyarthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, recombinant IL-29 augmented the mRNA expression of IL-1β, IL-6, IL-8, and matrix-metalloproteinase-3 (MMP-3) in OA FLS and increased cartilage degradation when ex vivo OA cartilage explant was coincubated with OA FLS.
|
27433031 |
2016 |
Degenerative polyarthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Methylation, particularly hypomethylation of genes including IL-8 and CCL3L3 could make positive effects on OA progress.
|
26171692 |
2015 |
Degenerative polyarthritis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Three CpG sites in the IL8 promoter were significantly demethylated in OA patients.
|
26521741 |
2015 |
Degenerative polyarthritis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
For the first time, the current data suggested that the TT genotype and T allele of the IL-8 gene polymorphisms at positions -251 and +781 might confer a high risk of osteoarthritis.
|
25194757 |
2014 |
Degenerative polyarthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The expression levels of TLR3, VEGF, and IL-8 were significantly higher in the RA synovium than in the OA synovium.
|
21179282 |
2010 |
Degenerative polyarthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
We determined the mRNA expression and protein production of IL-6, IL-8, and MMP-13, which are involved in the progression of OA, were increased in the osteophytes.
|
19333684 |
2009 |
Degenerative polyarthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
We investigated the signaling pathway involved in IL-8 production caused by leptin in both rheumatoid arthritis synovial fibroblasts (RASF) and osteoarthritis synovial fibroblasts (OASF).
|
18501560 |
2008 |
Degenerative polyarthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The levels of TLR-2, VEGF and IL-8 were analyzed by dual immunohistochemistry in RA synovium and compared with osteoarthritis (OA).
|
17182109 |
2007 |
Degenerative polyarthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In our previous studies, we found higher synovial fluid (SF) levels of angiogenic ELR(+) CXC chemokines such as CXCL1, CXCL5, CXCL6 and CXCL8, which play an important role in neutrophil migration and angiogenesis, and more abundant synovial CXCR2 chemokine receptor expression in patients with rheumatoid arthritis (RA) than those with Behçet's disease (BD), familial Mediterranean fever and osteoarthritis (OA).
|
17265155 |
2007 |
Degenerative polyarthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
To evaluate the role of CXC chemokines CXCL8 (IL8), CXCL10 (IP-10), CXCL12 (SDF-1), and CXCL13 (BCA-1) in bone remodeling, we analyzed their effects on osteoblasts (OBs) obtained from subchondral trabecular bone tissue of osteoarthritis (OA) and post-traumatic (PT) patients.
|
15965952 |
2006 |
Degenerative polyarthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Expression of IGFBP7, ADAMTS3, and IL8 in adult OA articular cartilage chondrocytes was demonstrated by reverse transcription-polymerase chain reaction.
|
15708897 |
2005 |