|
Tumor Angiogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Since acquisition of Gem‑R increased IL‑8 production and consequently increased tumor angiogenesis, the IL‑8/CXCR2 axis may be a potential novel therapeutic target for PaCa after acquiring Gem‑R.
|
31002348 |
2019 |
|
Tumor Angiogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Thus, our results support the concept that the ZO-1 shuttle from the cell junction to the cytonuclear compartment may affect both the intrinsic invasive properties of tumor cells and the establishment of the protumoral microenvironment.-Lesage, J., Suarez-Carmona, M., Neyrinck-Leglantier, D., Grelet, S., Blacher, S., Hunziker, W., Birembaut, P., Noël, A., Nawrocki-Raby, B., Gilles, C., Polette, M. Zonula occludens-1/NF-κB/CXCL8: a new regulatory axis for tumor angiogenesis.
|
28057697 |
2017 |
|
Tumor Angiogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
These results indicate overexpressed HMGB1 contributes to tumor angiogenesis through IL-8 mediation, and combined targeting of HMGB1 and IL-8 can control tumor angiogenesis in GC.
|
28574630 |
2017 |
|
Tumor Angiogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Therefore, regulation of HIFs and IL-8 controlled the tumor microenvironment in terms of tumor angiogenesis and apoptosis.
|
28053598 |
2017 |
|
Tumor Angiogenesis
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Overexpression of IL-8 in pancreatic tumors is believed to promote tumor angiogenesis and to activate survival signaling pathways.
|
27749658 |
2017 |
|
Tumor Angiogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Interleukin-8 (IL-8) influences proliferation and tumor angiogenesis and it is expressed in cancer.
|
25832725 |
2017 |
|
Tumor Angiogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
In TCEB2 overexpressing cells, interleukin-8 (IL-8) was elevated and functioned as a compensatory angiogenesis signaling which was sensitive to IL-8 monoclonal antibody (IL-8 Ab).
|
26531153 |
2016 |
|
Tumor Angiogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Interleukin-8 (IL-8) induces tumor angiogenesis independent of the VEGF pathway through the chemokine C-X-C motif receptor 2 (CXCR-2).
|
23548249 |
2013 |
|
Tumor Angiogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
IL-17 and its downstream signaling mediator, interleukin-8 (IL-8), have been implicated to modulate a variety of pro-angiogenic factors and play important roles in tumor angiogenesis and metastasis.
|
23349885 |
2013 |
|
Tumor Angiogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Interleukin-8 (IL-8), a proinflammatory chemokine, plays an important role during tumor angiogenesis and metastasis.
|
21266854 |
2011 |
|
Tumor Angiogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The in vitro and in vivo synergistic antitumor activity elicited by Ad-ING4-IL-24 was closely associated with the cooperative activation of extrinsic and intrinsic apoptotic pathways and reduced proangiogenic factors' production of VEGF and IL-8, leading to synergistic inhibition of tumor angiogenesis.
|
21988227 |
2011 |
|
Tumor Angiogenesis
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Constitutive NF-kappaB activity regulates the expression of VEGF and IL-8 and tumor angiogenesis of human glioblastoma.
|
20127012 |
2010 |
|
Tumor Angiogenesis
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
This retarded MDA-MB-231 breast carcinoma growth in vitro and in vivo elicited by Ad-ING4 closely correlated with the upregulation of cell cycle-related molecules P21 and P27, decrease in the ratio of anti- to proapoptotic molecules Bcl-2/Bax, release of cytochrome c from mitochondria into cytosol followed by caspase-9 and -3 activation leading to apoptosis via intrinsic apoptotic pathway, and the reduced expression of proangiogenic factors IL-8 and Ang-1 involved in the inhibition of tumor angiogenesis.
|
20707719 |
2010 |
|
Tumor Angiogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
This retarded tumor growth in vivo elicited by IL-17F was associated with direct suppression of vascular endothelial cells and reduced expression of proangiogenic factors IL-6, IL-8, and VEGF leading to the inhibition of tumor angiogenesis.
|
20210523 |
2010 |
|
Tumor Angiogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
In this report, we examined whether tumor angiogenesis and growth of CXCL-8-expressing human melanoma cells are regulated in vivo by a host CXCR2-dependent mechanism.
|
19147552 |
2009 |
|
Tumor Angiogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Because hypoxia-inducible factor-1alpha (HIF-1alpha), its downstream target vascular endothelial growth factor (VEGF), and other angiogenic factors such as interleukin-8 (IL-8) and cyclooxygenase 2 (COX-2) play critical roles in neovascularization, we tested the hypothesis that the inhibitory effect of T3 on tumor angiogenesis is via regulation of these angiogenic factors.
|
18936210 |
2008 |
|
Tumor Angiogenesis
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
These findings indicate that at the early stage of tumor growth, bFGF and IL-8 expression play important roles in the regulation of angiogenesis, tumorigenicity and subsequent metastases of human bladder cancer.
|
19096229 |
2008 |
|
Tumor Angiogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The induction of vascular endothelial growth factor (VEGF) and interleukin-8 (IL-8) is an essential feature of tumor angiogenesis, and the hypoxia-inducible factor-1 (HIF-1) transcription factor is known to be a key regulator of this process.
|
17488804 |
2007 |
|
Tumor Angiogenesis
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Our previous study has shown that glucocorticoids inhibit tumor angiogenesis possibly by down-regulation of vascular endothelial growth factor (VEGF) and interleukin 8.
|
17062674 |
2006 |
|
Tumor Angiogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Furthermore, interleukin-8 (IL-8), recently identified as an EGFR downstream effector, plays a vital role in tumor angiogenesis and progression.
|
16098254 |
2005 |
|
Tumor Angiogenesis
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
The present data are consistent with previous observations that link NO to enhanced tumor angiogenesis and imply that NO-mediated upregulation of IL-8 and VEGF as well as downregulation of IP-10 and MIG may contribute to this phenomenon.
|
15063730 |
2004 |
|
Tumor Angiogenesis
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Up-regulation of tumor interleukin-8 expression by infiltrating macrophages: its correlation with tumor angiogenesis and patient survival in non-small cell lung cancer.
|
12576442 |
2003 |
|
Tumor Angiogenesis
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
In summary, we demonstrated that MCP-1 and M-CSF, critical for monocyte recruitment, activation and differentiation, differentially regulate IL-8 expression and may play an important role in monocyte/macrophage-mediated tumor angiogenesis.
|
12494891 |
2003 |
|
Tumor Angiogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
To evaluate interactions between expressions of tumor suppressor gene p53 and angiogenic factors vascular endothelial cell growth factor (VEGF) and interleukin-8 (IL-8) and their effect on tumor angiogenesis and patient prognosis in non--small-cell lung cancer (NSCLC).
|
11844810 |
2002 |
|
Tumor Angiogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Interleukin 8 (IL-8) and vascular endothelial growth factor (VEGF) promote tumor angiogenesis, growth, and metastasis and are coexpressed by human head and neck squamous cell carcinomas (HNSCCs) and a variety of other cancers.
|
11234901 |
2001 |