Liver carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of CPAP upregulates several STAT3 target genes such as IL-8 and CD44 that are involved in angiogenesis, and CPAP mRNA expression is positively correlated with the levels of both mRNAs in HCC.
|
31511651 |
2020 |
Liver carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The rates of high IL-8 and ERK2 expression in HCC tissues were 43.28 (29/67) and 34.33% (23/67), respectively, and the IL-8 and ERK2 expression levels were positively correlated (r=0.764; P<0.001).
|
31612032 |
2019 |
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Wound healing, transwell, and western blotting assay results showed that IL-8 promotes the migration and invasion of Huh-7 and HepG2 cells, and the underlying mechanism is that IL-8 induces the EMT of HCC cells via the IL-8/ERK1/2/SNAI1 and IL-8/STAT3/TWIST1 signalling pathways.
|
30903867 |
2019 |
Liver carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Baseline HRQoL using the conventional assessments of EORTC QLQ-C30 and QLQ-HCC18, as well as C30 and HCC18 index-scores, significantly correlated with inflammatory indicators (IL-8 level and mIBI) in HCC patients.
|
31040713 |
2019 |
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
RNA sequencing analysis revealed EMT inducers HIF1α/IL8 and Sox4 as potential mediators for the oncogenic effect of ABCF1 in HCC progression.
|
31100412 |
2019 |
Liver carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
An inverse correlation between <i>PHB1</i> and <i>IL-8</i> mRNA levels is found in HCCs with reduced PHB1 expression.
|
30523154 |
2019 |
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
IL-8 induced HCC cell invasion and integrin β3 expression was significantly inhibited by transfection with CXCR1 siRNA or CXCR2 siRNA.
|
31684995 |
2019 |
Liver carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Changes in plasma interleukin-8 and TNF-α levels during the first few days could predict the response to sorafenib therapy in HCC patients.
|
30178114 |
2018 |
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
IL-8, which promoted EMT and HCC invasion both <i>in vitro</i> and <i>in vivo</i>, was produced by NTS-induced HCC cells and was effectively attenuated by blocking IL-8 receptors <i>in vitro</i>.
|
29900041 |
2018 |
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Multivariate analyses identified IL6 and IL8 as independent predictors of OS.<b>Conclusions:</b> Foretinib demonstrated promising antitumor activity and good tolerability in the first-line setting in Asian advanced hepatocellular carcinoma patients.
|
27821605 |
2017 |
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The expression of miR-18a and miR-19a (belonging to miR-17 cluster) increased in HCC cells by CXCL8 simulation and led to the enhancement of HCC cell proliferation and metastasis.
|
28559990 |
2017 |
Liver carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The objectives of the present study were: i) To investigate the association between soluble B7-H3 (sB7-H3) and cytokine levels of IL-17, IL-8 and IL-6 in the serum of patients with hepatocellular carcinoma (HCC); and ii) to determine their potential value for use in HCC diagnosis.
|
29344257 |
2017 |
Liver carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Prospero-related homeobox 1 drives angiogenesis of hepatocellular carcinoma through selectively activating interleukin-8 expression.
|
28646551 |
2017 |
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
By flow cytometry, we observed a significant IL-8 decrease which is closely related to the tumoral progression and chemotherapeutic resistance, especially in HCC.
|
28242545 |
2017 |
Liver carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Expressions of glutathione S-transferase pi 1 (GSTP1), lysozyme (LYZ), C-X-C motif chemokine ligand 5 (CXCL5), interleukin-8 (IL8) and dickkopf WNT signaling pathway inhibitor 1 (DKK1), the five most highly expressed genes in the CSC cDNA microarray databases, were examined in 99 patients with HCC by real-time polymerase chain reaction (qRT-PCR), and their clinical significance was analyzed.
|
28870909 |
2017 |
Liver carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Interleukin-8 Induces Expression of FOXC1 to Promote Transactivation of CXCR1 and CCL2 in Hepatocellular Carcinoma Cell Lines and Formation of Metastases in Mice.
|
26065367 |
2015 |
Liver carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Co-expression of HIF-1α and CXCL8 is a prognostic marker and a potential therapeutic target in HCC.
|
26078356 |
2015 |
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
We found that IL-8: i) may induce EMT and promote HCC cell migration and invasion and ii) is associated with the JAK2/STAT3/Snail signaling pathway.
|
25405790 |
2015 |
Liver carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The serum level of IL8 was significantly higher in HCC patients compared with healthy controls (P < 0.001).
|
24381110 |
2014 |
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
EGF prompted the cell movement in both HepG2 and HCCLM3 and regulated the production of CXCL5 and CXCL8 from HCC, which were inhibited by EGFR inhibitor, Erk inhibitor (U0126), or PI3K inhibitors (BEZ-235 and SHBM1009).
|
24268047 |
2014 |
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
These findings indicate that shRNA-induced HIF-1α and IL-8 knockdown inhibit angiogenesis and tumour growth in HCC.
|
24321089 |
2014 |
Liver carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Both IL-8 and ABC transporters were highly expressed in xenograft and clinical HCC tissues, and knockdown of IL-8 significantly reduced tumour size in vivo.
|
24161763 |
2014 |
Liver carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Significantly increased IL-8 protein was confirmed in 90.91% of NTS(+) HCC samples and significantly positively correlated to the levels of NTS protein in cancer tissues (P = 0.036), which implied activation of NTS/IL-8 pathway in HCC.
|
23418512 |
2013 |
Liver carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In contrast, either interleukin-8 (IL-8) or basic fibroblast growth factor (bFGF) was upregulated in HCC.
|
23970062 |
2013 |
Liver carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We hypothesize that the functional polymorphism of IL-8 may influence the inflammatory process during pathological stage from hepatitis to hepatocellular carcinoma (HCC).
|
22335768 |
2012 |