Neutrophilia (disorder)
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We provide molecular and translational evidence that EGFR/MEKi in concert with the skin commensal bacterium Cutibacterium acnes act synergistically to induce IL-36γ in keratinocytes and subsequently IL-8, leading to cutaneous neutrophilia.
|
31805013 |
2020 |
Neutrophilia (disorder)
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Patients treated with azithromycin demonstrated less airway inflammation, with lower bronchoalveolar lavage (BAL) neutrophilia and BAL interleukin-8 protein levels at Day 30 (p = 0.09 and p = 0.04, respectively) and Day 90 (p = 0.002 and p = 0.08, respectively) after LTx.
|
30686699 |
2019 |
Neutrophilia (disorder)
|
0.100 |
Biomarker
|
disease |
BEFREE |
IL-17 producing ILC2s induce IL-8 secretion by epithelial cells and their presence in nasal polyps of CF patients is associated with neutrophilia.
|
31089134 |
2019 |
Neutrophilia (disorder)
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Persistent IL-8 expression in bronchial epithelium resulted in neutrophilia, neutrophil maturation and activation, and chemotaxis.
|
29894204 |
2018 |
Neutrophilia (disorder)
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Subjects with sputum neutrophilia had more severe bronchiectasis in HRCT and higher levels of IL-8 in sputum, whereas subjects with eosinophilia had higher levels of FeNO, greater bronchodilator reversibility and higher sputum IL-13.
|
28863927 |
2017 |
Neutrophilia (disorder)
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Among 11 cytokines profiled, serum levels of interleukin (IL)-2, IL-5, and IL-8 were clearly increased in all 4 positive OFCs in which elevations of the serum level of C-reactive protein (CRP) and peripheral blood neutrophilia were also seen.
|
28057433 |
2017 |
Neutrophilia (disorder)
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
IL-1β and IL-8 protein levels were significantly increased in sputum of patients with severe asthma and were positively associated with sputum neutrophilia.
|
27155035 |
2016 |
Neutrophilia (disorder)
|
0.100 |
Biomarker
|
disease |
BEFREE |
We found that both clarithromycin and dexamethasone up-regulated the production of anti-inflammatory mediators (Clara cell 10-kDa protein and interleukin (IL)-10), whereas down-regulated the production of Th2 response and eosinophilia promoting molecules (thymic stromal lymphopoietin, IL-25, IL-33, CD80, CD86, OX40 ligand, programmed cell death ligand 1, CCL17, CCL22, CCL11, CCL5, IL-5, IL-13, and eosinophilic cationic protein) and Th1 response and neutrophilia promoting molecules (CXCL8, CXCL5, CXCL10, CXCL9, interferon-γ, and IL-12), from sinonasal mucosa from distinct phenotypic CRS.
|
26047816 |
2015 |
Neutrophilia (disorder)
|
0.100 |
Biomarker
|
disease |
BEFREE |
Infectious Chlamydia pneumoniae is associated with elevated interleukin-8 and airway neutrophilia in children with refractory asthma.
|
21155094 |
2010 |
Neutrophilia (disorder)
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Children with PBB had marked airway neutrophilia and increased median cytokine levels when compared to those with cough that resolved naturally and no cough controls: IL-8 0.67 versus 0.07 and 0.06 ng/ml (P < 0.005) and active MMP-9 7.25 versus 1.35 and 0.38 ng/ml (P < 0.005).
|
18846558 |
2008 |
Neutrophilia (disorder)
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
There was a significantly higher expression of IL-8 and other proinflammatory cytokines in results from 32 biopsies with neutrophilia than in those from 12 biopsies without acute inflammation.
|
16622230 |
2006 |
Neutrophilia (disorder)
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Using categorical univariate linear regression analysis, the main significant differences in characteristics between responders and nonresponders were the initial BAL neutrophilia (p < 0.0001), IL-8 mRNA ratio (p = 0.0009), and the postoperative day at which azithromycin was started (p = 0.036).
|
16741151 |
2006 |
Neutrophilia (disorder)
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The failure of oral corticosteroids to inhibit IL-8 mRNA expression might contribute to persistent airway neutrophilia observed in patients with moderate-to-severe asthma, despite treatment with corticosteroids.
|
15696082 |
2005 |
Neutrophilia (disorder)
|
0.100 |
Biomarker
|
disease |
BEFREE |
Healthy subjects developed airway inflammation 6 h after DE exposure, with airways neutrophilia and lymphocytosis together with an increase in interleukin-8 (IL-8) protein in lavage fluid, increased IL-8 messenger ribonucleic acid expression in the bronchial mucosa and upregulation of the endothelial adhesion molecules.
|
14738236 |
2004 |
Neutrophilia (disorder)
|
0.100 |
Biomarker
|
disease |
BEFREE |
Human CXCL8 produced in vivo neutrophilia, chemotaxis and intracellular calcium release of guinea pig neutrophils.
|
14505796 |
2003 |
Neutrophilia (disorder)
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Interleukin-8 gene expression and protein release were increased in allergic bronchopulmonary aspergillosis and correlated with airway neutrophilia and airway obstruction.
|
12762339 |
2003 |