CXCL8, C-X-C motif chemokine ligand 8, 3576

N. diseases: 109; N. variants: 1
Source: CURATED ×
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0024117
Disease: Chronic Obstructive Airway Disease
Chronic Obstructive Airway Disease 		0.400 Biomarker disease CTD_human MicroRNA-218 acts by repressing TNFR1-mediated activation of NF-κB, which is involved in MUC5AC hyper-production and inflammation in smoking-induced bronchiolitis of COPD. 28864214 2017
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.400 Biomarker disease CTD_human Autotaxin is an inflammatory mediator and therapeutic target in thyroid cancer. 26037280 2015
CUI: C0344315
Disease: Depressed mood
Depressed mood 		0.400 Biomarker phenotype PSYGENET TNF-α -308G/A and IL-8 -251T/A were significantly associated with AD and IL-1β +3953C/T with late-life depression, while the significance of these associations was lost after Bonferroni correction. 25315113 2015
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma 		0.400 Biomarker disease CTD_human Autotaxin is an inflammatory mediator and therapeutic target in thyroid cancer. 26037280 2015
CUI: C0021368
Disease: Inflammation
Inflammation 		0.400 Biomarker phenotype CTD_human Salmon and king crab trypsin stimulate interleukin-8 and matrix metalloproteinases via protease-activated receptor-2 in the skin keratinocytic HaCaT cell line. 24795235 2014
CUI: C0024117
Disease: Chronic Obstructive Airway Disease
Chronic Obstructive Airway Disease 		0.400 Biomarker disease CTD_human Decreased FoxO3A in COPD cells was associated with increased phosphorylation of EGFR, Akt and FoxO3A and treatment with quercetin, LY294002 or erlotinib increased nuclear FoxO3A and decreased IL-8 and phosphorylation of Akt, EGFR and FoxO3A, Compared with control, elastase/LPS-exposed mice showed decreased nuclear FoxO3A, increased chemokines and phosphorylation of EGFR and Akt. 23099361 2013
CUI: C0344315
Disease: Depressed mood
Depressed mood 		0.400 Biomarker phenotype PSYGENET In this study, we tested the leukocyte mRNA expression levels of genes belonging to glucocorticoid receptor (GR) function (FKBP-4, FKBP-5, and GR), inflammation (interleukin (IL)-1α, IL-1β, IL-4, IL-6, IL-7, IL-8, IL-10, macrophage inhibiting factor (MIF), and tumor necrosis factor (TNF)-α), and neuroplasticity (brain-derived neurotrophic factor (BDNF), p11 and VGF), in healthy controls (n=34) and depressed patients (n=74), before and after 8 weeks of treatment with escitalopram or nortriptyline, as part of the Genome-based Therapeutic Drugs for Depression study. 22990943 2013
CUI: C0344315
Disease: Depressed mood
Depressed mood 		0.400 Biomarker phenotype PSYGENET The associations between physical disorders and incident depression were significant in the presence of 2 alleles related to higher proinflammatory cytokine production (tumor necrosis factor-α -850T and IL-8 -251A), and 1 allele related to lower anti-inflammatory cytokine production (IL-4 +33C). 22921153 2013
CUI: C0344315
Disease: Depressed mood
Depressed mood 		0.400 Biomarker phenotype PSYGENET Genetic variations in interleukin-8 and interleukin-10 are associated with pain, depressed mood, and fatigue in lung cancer patients. 23149083 2013
CUI: C0005684
Disease: Malignant neoplasm of urinary bladder
Malignant neoplasm of urinary bladder 		0.400 Biomarker disease CTD_human Interleukin-8 (IL-8) over-production and autocrine cell activation are key factors in monomethylarsonous acid [MMA(III)]-induced malignant transformation of urothelial cells. 22015448 2012
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm 		0.400 Biomarker disease CTD_human Interleukin-8 (IL-8) over-production and autocrine cell activation are key factors in monomethylarsonous acid [MMA(III)]-induced malignant transformation of urothelial cells. 22015448 2012
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.400 Biomarker disease CTD_human Autocrine production of interleukin-8 confers cisplatin and paclitaxel resistance in ovarian cancer cells. 21742513 2011
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary 		0.400 Biomarker disease CTD_human Autocrine production of interleukin-8 confers cisplatin and paclitaxel resistance in ovarian cancer cells. 21742513 2011
CUI: C0021368
Disease: Inflammation
Inflammation 		0.400 Biomarker phenotype CTD_human trans-resveratrol inhibits hyperglycemia-induced inflammation and connexin downregulation in retinal pigment epithelial cells. 20578705 2010
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.400 Biomarker disease CTD_human Antirheumatic drug response signatures in human chondrocytes: potential molecular targets to stimulate cartilage regeneration. 19192274 2009
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.400 Biomarker disease CTD_human We conclude that 1) colorectal carcinogenesis is accompanied by increased synthesis and release of proinflammatory cytokines such as IL-6 and IL-8; 2) simvastatin therapy results in a decrease in serum level of proinflammatory cytokines, especially IL-6 in CRC and 3) simvastatin inhibits release of IL-8 and IL-6 from colorectal cell lines. 20065508 2009
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.400 Biomarker disease CTD_human Reciprocal regulation of 17beta-estradiol, interleukin-6 and interleukin-8 during growth and progression of epithelial ovarian cancer. 19401270 2009
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary 		0.400 Biomarker disease CTD_human Reciprocal regulation of 17beta-estradiol, interleukin-6 and interleukin-8 during growth and progression of epithelial ovarian cancer. 19401270 2009
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma 		0.400 Biomarker group CTD_human Interleukin-8 increases vascular endothelial growth factor and neuropilin expression and stimulates ERK activation in human pancreatic cancer. 18307536 2008
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas 		0.400 Biomarker disease CTD_human Interleukin-8 increases vascular endothelial growth factor and neuropilin expression and stimulates ERK activation in human pancreatic cancer. 18307536 2008
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.400 Biomarker disease CTD_human Gene expression profiling of rheumatoid arthritis synovial cells treated with antirheumatic drugs. 17379860 2007
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.400 Biomarker disease CTD_human Serum cytokine levels of interleukin-1beta, -6, -8, tumour necrosis factor-alpha and vascular endothelial growth factor in breast cancer patients treated with tamoxifen and supplemented with co-enzyme Q(10), riboflavin and niacin. 17516992 2007
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.400 Biomarker group CTD_human Interleukin-8 signaling promotes translational regulation of cyclin D in androgen-independent prostate cancer cells. 17606477 2007
CUI: C0344315
Disease: Depressed mood
Depressed mood 		0.400 Biomarker phenotype PSYGENET Logistic regression analyses showed that after controlling for epidemiologic (age and sex), clinical (stage of disease, comorbidities), and symptom (depressed mood and fatigue) variables known to influence pain severity, variant alleles in IL-8 -251T/A [odds ratio (OR), 2.35; 95% confidence interval (95% CI), 1.10-5.03; P = 0.03] persisted as a significant factor for severe pain for White patients. 18086782 2007
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.400 Biomarker disease CTD_human Interleukin-8 signaling promotes translational regulation of cyclin D in androgen-independent prostate cancer cells. 17606477 2007