|
HIV Infections
|
0.320 |
Biomarker
|
group |
CTD_human |
|
|
|
|
HIV Coinfection
|
0.300 |
Biomarker
|
disease |
CTD_human |
|
|
|
|
Glioblastoma Multiforme
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Hypoxic/anoxic insults on glioblastoma cells in vitro using anaerobic chamber systems or within spheroids developing central necrosis induced an increase in IL-8 messenger RNA (mRNA) and protein expression. mRNA for IL-8-binding chemokine receptors CXCR1, CXCR2, and the Duffy antigen receptor for chemokines (DARC) were found in all astrocytoma grades by reverse transcription/PCR analysis.
|
9334359 |
1997 |
|
Glioblastoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Hypoxic/anoxic insults on glioblastoma cells in vitro using anaerobic chamber systems or within spheroids developing central necrosis induced an increase in IL-8 messenger RNA (mRNA) and protein expression. mRNA for IL-8-binding chemokine receptors CXCR1, CXCR2, and the Duffy antigen receptor for chemokines (DARC) were found in all astrocytoma grades by reverse transcription/PCR analysis.
|
9334359 |
1997 |
|
Adult Glioblastoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Hypoxic/anoxic insults on glioblastoma cells in vitro using anaerobic chamber systems or within spheroids developing central necrosis induced an increase in IL-8 messenger RNA (mRNA) and protein expression. mRNA for IL-8-binding chemokine receptors CXCR1, CXCR2, and the Duffy antigen receptor for chemokines (DARC) were found in all astrocytoma grades by reverse transcription/PCR analysis.
|
9334359 |
1997 |
|
Childhood Glioblastoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Hypoxic/anoxic insults on glioblastoma cells in vitro using anaerobic chamber systems or within spheroids developing central necrosis induced an increase in IL-8 messenger RNA (mRNA) and protein expression. mRNA for IL-8-binding chemokine receptors CXCR1, CXCR2, and the Duffy antigen receptor for chemokines (DARC) were found in all astrocytoma grades by reverse transcription/PCR analysis.
|
9334359 |
1997 |
|
Psoriasis
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
In this study, we examined the expression of both CXCR1 and CXCR2 in psoriatic tissue, identifying the target cells of chemokine activation in psoriasis.
|
9424095 |
1998 |
|
Carcinoma
|
0.020 |
Biomarker
|
group |
BEFREE |
To determine whether IL-8 can act in an autocrine manner to regulate the expression of other disease-progression genes, we examined the expression of IL-8 receptors IL-8RA (CXCR1) and IL-8RB (CXCR2) in six different human gastric carcinoma cell lines and 38 surgical specimens of human gastric carcinomas.
|
10914718 |
2000 |
|
Immunologic Deficiency Syndromes
|
0.010 |
Biomarker
|
group |
BEFREE |
Overexpression of chemokine receptors including CCR2b, CXCR1 and CXCR2 in infected astrocytic cells may contribute to HIV-induced damage of the CNS via autocrine/paracrine activation of astrocytes.
|
10786999 |
2000 |
|
Rheumatism
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In this study, systematic variation screening of the entire coding regions of CXCR1 (IL8RA), CXCR2 (IL8RB) and CXCR3 was carried out, using genomic DNA from a large number of Japanese healthy individuals and patients with rheumatic diseases.
|
11196695 |
2000 |
|
Hamman-Rich syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
To search for single-nucleotide polymorphisms in the interleukin-8 (IL-8) and IL-8 receptor CXCR-1 and CXCR-2 genes, and to compare their distribution among patients with systemic sclerosis (SSc) with fibrosing alveolitis (FASSc) or without fibrosing alveolitis (NFASSc), or patients with cryptogenic fibrosing alveolitis (CFA), and normal healthy subjects.
|
10902769 |
2000 |
|
Idiopathic Pulmonary Fibrosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
To search for single-nucleotide polymorphisms in the interleukin-8 (IL-8) and IL-8 receptor CXCR-1 and CXCR-2 genes, and to compare their distribution among patients with systemic sclerosis (SSc) with fibrosing alveolitis (FASSc) or without fibrosing alveolitis (NFASSc), or patients with cryptogenic fibrosing alveolitis (CFA), and normal healthy subjects.
|
10902769 |
2000 |
|
Chronic idiopathic pulmonary fibrosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
To search for single-nucleotide polymorphisms in the interleukin-8 (IL-8) and IL-8 receptor CXCR-1 and CXCR-2 genes, and to compare their distribution among patients with systemic sclerosis (SSc) with fibrosing alveolitis (FASSc) or without fibrosing alveolitis (NFASSc), or patients with cryptogenic fibrosing alveolitis (CFA), and normal healthy subjects.
|
10902769 |
2000 |
|
Alveolitis, Fibrosing
|
0.010 |
Biomarker
|
disease |
BEFREE |
To search for single-nucleotide polymorphisms in the interleukin-8 (IL-8) and IL-8 receptor CXCR-1 and CXCR-2 genes, and to compare their distribution among patients with systemic sclerosis (SSc) with fibrosing alveolitis (FASSc) or without fibrosing alveolitis (NFASSc), or patients with cryptogenic fibrosing alveolitis (CFA), and normal healthy subjects.
|
10902769 |
2000 |
|
Neoplasm Metastasis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
In the present study, we examined the expression of a multifunctional cytokine, interleukin 8 (IL-8), and its receptors, CXCR1 and CXCR2, in human colon carcinoma cells with different metastatic potentials and determined their role in modulating phenotypes associated with metastasis.
|
11595728 |
2001 |
|
Acute pyelonephritis
|
0.070 |
AlteredExpression
|
disease |
BEFREE |
Low CXCR1 expression was also detected in children with acute pyelonephritis.
|
11404374 |
2001 |
|
Psoriasis
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
We studied chemokine receptor (CCR1-CCR5, CXCR1-CXCR3), chemokine (interferon-gamma inducible protein 10 [IP-10]), monokine induced by interferon-gamma (MIG), thymus and activation-regulated chemokine (TARC), macrophage-derived chemokine (MDC), and adhesion molecule (cutaneous lymphocyte antigen [CLA], E-selectin, lymphocyte function-associated antigen-1 [LFA-1], intercellular adhesion molecule-1 [ICAM-1], very late antigen 4 [VLA-4], vascular cell adhesion molecule-1 [VCAM-1], alphaEbeta7, and E-cadherin) expression in psoriasis by immunohistology, flow cytometry, and molecular techniques.
|
11310827 |
2001 |
|
Fibroid Tumor
|
0.010 |
Biomarker
|
disease |
BEFREE |
Immunostaining for both interleukin 8 and interleukin 8 receptor type A was stronger in the myometrium adjacent to leiomyoma compared with leiomyoma itself (2-fold, P <.05).
|
11262453 |
2001 |
|
Uterine Fibroids
|
0.010 |
Biomarker
|
group |
BEFREE |
Immunostaining for both interleukin 8 and interleukin 8 receptor type A was stronger in the myometrium adjacent to leiomyoma compared with leiomyoma itself (2-fold, P <.05).
|
11262453 |
2001 |
|
Recurrent pyelonephritis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Here we discuss the mechanisms of neutrophil-mediated, chemokine receptor (CXCR1)-dependent clearance, and the defect in interleukin-8 receptor homolog knock-out (IL-8Rh KO) mice and describe the data linking low CXCR1 expression to recurrent pyelonephritis in man, as well as the information on the genetic basis for low CXCR1 expression in affected patients.
|
11817650 |
2001 |
|
melanoma
|
0.040 |
AlteredExpression
|
disease |
LHGDN |
In summary, the data suggest that constitutive expression of CXCR1 and CXCR2 play an important role regulating the IL-8-mediated metastatic phenotype in human malignant melanoma cells.
|
14713106 |
2003 |
|
Rheumatoid Arthritis
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Elevated protein levels in RA synovial tissue were detected for CXCR1 and CXCR3 by Western blotting.
|
12932287 |
2003 |
|
Tuberculosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
CXCR-1 and CXCR-2 did not demonstrate significant associations with TB susceptibility.
|
12870115 |
2003 |
|
Chronic Obstructive Airway Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In comparison with the nonrespiratory surgical procedure and S-COPD groups, neutrophilia and gene expression for epithelial-derived neutrophil attractant-78 (CXCL5), interleukin-8 (CXCL8), CXCR1, and CXCR2 were each upregulated in the E-COPD group (p < 0.01); compared with the S-COPD group, by 97-, 6-, 6-, 3-, and 7-fold, respectively (p < 0.01).
|
12857718 |
2003 |
|
Allergic rhinitis (disorder)
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In vivo nasal bradykinin challenge significantly increased CXCR1 and CXCR2 mRNA expression in patients with quiescent allergic rhinitis but had no effect in healthy control subjects.
|
12532104 |
2003 |