|
Pemphigoid, Benign Mucous Membrane
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Conjunctival expression of IL8 and CXCR1 was significantly increased in oMMP patients when compared to both healthy subjects and pSS patients.
|
31486595 |
2020 |
|
stage, ovarian epithelial cancer
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, the level of IL-8 and its receptors CXCR1 and CXCR2 expression were associated with ovarian cancer stage, grade and lymph node metastasis.
|
31793192 |
2020 |
|
Secondary malignant neoplasm of lymph node
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, the level of IL-8 and its receptors CXCR1 and CXCR2 expression were associated with ovarian cancer stage, grade and lymph node metastasis.
|
31793192 |
2020 |
|
Sjogren's Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
The significant increase of tear and conjunctival IL8 and CXCR1 levels in patients with oMMP when compared to healthy subjects and patients with Sjogren syndrome suggests that changes of IL8 pathway are specific of oMMP and may represent a potential biomarker of the disease and/or therapeutic target.
|
31486595 |
2020 |
|
Alzheimer's Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
The chemokine C-C receptor 3 (CCR3) plays a role in the pathogenesis of Alzheimer's disease (AD).
|
31121157 |
2019 |
|
Bacterial Infections
|
0.010 |
AlteredExpression
|
group |
BEFREE |
We can conclude that targeting of TNFR1 and IL-1R (with major focus on surface expression study) either through blockage of intracellular receptor trafficking pathway or via surface receptor shedding diminishes TNFR1/IL-1R interaction and consequently downregulates CXCR1 expression along with inflammatory signalling pathways during bacterial infections.
|
31290001 |
2019 |
|
Renal Cell Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
IL-8 and CXCR1 expression is associated with cancer stem cell-like properties of clear cell renal cancer.
|
30883740 |
2019 |
|
Colitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here, we use RNA interference to target CXCL8 and its receptor, CXCR1, to establish the existence of a functional signaling pathway promoting tumor growth initiated by sporadic and colitis CCSCs.
|
30738331 |
2019 |
|
HTLV-I Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
The aim of the study was to examine the relation of CXCR1 and CXCR2, both of which are involved in the trafficking of lymphocytes into the CNS, with the outcome of HTLV-1 infection.
|
30341468 |
2019 |
|
Metabolic Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
The antagonist of CXCR1 and CXCR2 protects <i>db</i><i>/db</i> mice from metabolic diseases through modulating inflammation.
|
31573846 |
2019 |
|
Tropical Spastic Paraparesis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Different roles of CXCR1 and CXCR2 in HTLV-1 carriers and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients.
|
30341468 |
2019 |
|
Adult Liver Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The mRNA levels of CXCR1 and CXCR2 gradually increased with elevated expression of IL-8 in liver cancer.
|
31516616 |
2019 |
|
bone destruction
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our current findings may extend the utilization of SIN to preventing osteoclastogenesis and bone destruction in breast cancer patients and may enable IL-8/CXCR1 to serve as new targets for both anticancer and antiarthritic drug discovery.
|
30797069 |
2019 |
|
Systemic Inflammatory Response Syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
A total of 225 patients were divided into the SIRS group (<i>n</i> = 62) and non-SIRS group (control, <i>n</i> = 163), and we associated polymorphisms in <i>IL-8</i> [<i>rs4073</i> (-251T>A), <i>rs2227532</i> (-845C>T), <i>rs2227307</i> (+396G>T), <i>rs2227306</i> (+781T>C), <i>CXCR1 rs2234671</i> (+860C>G), <i>CXCR2</i> [<i>rs2230054</i> (+811T>C), <i>rs57929613</i> (+1235C>T), and <i>rs60626131</i> (+1440A>G)] with SIRS with a linear additive model.
|
31613654 |
2019 |
|
Carcinoma, Lewis Lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
We assessed the anticancer efficacies of the blockade of CXCL8-CXCR1/2 axis in the Lewis lung carcinoma (LL/2) model using CXCL8-IP10.
|
31571912 |
2019 |
|
Liver and Intrahepatic Biliary Tract Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The mRNA levels of CXCR1 and CXCR2 gradually increased with elevated expression of IL-8 in liver cancer.
|
31516616 |
2019 |
|
Solid Neoplasm
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
CXCR1- or CXCR2-modified CAR T cells co-opt IL-8 for maximal antitumor efficacy in solid tumors.
|
31488817 |
2019 |
|
Malignant neoplasm of liver
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The mRNA levels of CXCR1 and CXCR2 gradually increased with elevated expression of IL-8 in liver cancer.
|
31516616 |
2019 |
|
Aortic Aneurysm
|
0.010 |
Biomarker
|
disease |
BEFREE |
A role for CXCL8 in AAA disease was tested through the oral CXCR1/2 antagonist DF2156A in the elastase model of AAA disease.
|
29587155 |
2018 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Testing an association between TLR4 and CXCR1 gene polymorphisms with susceptibility to urinary tract infection in type 2 diabetes in north Indian population.
|
29066305 |
2018 |
|
Keloid
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Identification of the CXCR1 gene mutation might provide insights into the molecular mechanism underlying keloid scar and underscores the potential importance of mechanoreceptors in keloid scar pathogenesis.
|
29931443 |
2018 |
|
Cerebrovascular accident
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Our results suggest that modulating CXCR1 activity offers a novel therapeutic strategy for stroke.
|
29323156 |
2018 |
|
Aortic Aneurysm, Abdominal
|
0.010 |
Biomarker
|
disease |
BEFREE |
A role for CXCL8 in AAA disease was tested through the oral CXCR1/2 antagonist DF2156A in the elastase model of AAA disease.
|
29587155 |
2018 |
|
Van der Woude syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
In addition, DILC siRNA enhanced the expression of IL‑6, STAT3 and TLR4, whereas the expression levels of TNF‑α, CCL5, E‑selectin and CXCR1 in LPS‑treated THP‑1 cells were downregulated following transfection with DILC and IL‑6 siRNAs.
|
30365067 |
2018 |
|
Pancreatic carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
However, the effects of CXCR1/2 antagonist treatment on pancreatic cancer remain unclear.
|
29749433 |
2018 |