|
Psoriasis
|
0.200 |
Biomarker
|
disease |
BEFREE |
IL-20 is a proinflammatory cytokine of the IL-10 family that is involved in psoriasis, rheumatoid arthritis, atherosclerosis, and stroke.
|
21844205 |
2011 |
|
Psoriasis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
There were no significant differences in the distribution of enzyme polymorphisms or point mutations at position -1082 of the interleukin-10 promoter between the psoriasis groups and the control group.
|
10469306 |
1999 |
|
Psoriasis
|
0.200 |
Biomarker
|
disease |
BEFREE |
Regulatory B cells (Breg cells) producing IL-10 (B10 cells), a critical anti-inflammatory B-cell subset, were found to be decreased in both PsA and psoriasis.
|
31209492 |
2019 |
|
Psoriasis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
However, IL-10 (rs1800896) and FOXP3 (rs3761548) gene polymorphisms were not associated with psoriasis risk.
|
28027921 |
2017 |
|
Psoriasis
|
0.200 |
Biomarker
|
disease |
BEFREE |
IL-20, an IL-10 family member, is involved in various inflammatory diseases, such as psoriasis, rheumatoid arthritis, and atherosclerosis.
|
19342680 |
2009 |
|
Psoriasis
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Pearson correlation analysis showed that plasma IL-35 expression negatively correlated with interferon-gamma, tumor necrosis factor-alpha, levels of IL-23, -17, and -22, or the Psoriasis Activity and Severity Index and positively correlated with levels of transforming growth factor beta and IL-10 levels in patients with psoriasis.
|
29802736 |
2018 |
|
Psoriasis
|
0.200 |
AlteredExpression
|
disease |
LHGDN |
Peripheral blood samples were investigated for sHLA-G and IL-10 levels and for HLA-G 14 bp polymorphism in 65 patients with moderate-to-severe plaque psoriasis treated with systemic drugs or with topical or physical treatments and in controls.
|
18797896 |
2008 |
|
Psoriasis
|
0.200 |
Biomarker
|
disease |
BEFREE |
In contrast, recent studies indicate a relative IL-10 deficiency in psoriasis.
|
10651163 |
1999 |
|
Psoriasis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
For IL-10, patients with late onset psoriasis (over 40 years) were more likely to be heterozygous at position - 1082 (P = 0.02), corresponding to intermediate production of IL-10 in vitro and in vivo.
|
11298547 |
2001 |
|
Psoriasis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
There was a highly significant association between psoriasis and cytokine levels with an effect size of 0.829 and a particularly strong impact on IL-2 (0.463), IL-12 (0.451), IL-10 (0.532) and adiponectin (0.401).
|
31062065 |
2019 |
|
Psoriasis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
No significant differences were found in the polymorphisms of IL-6 and IL-10 promoter genes between patients with psoriasis and healthy controls.
|
18311435 |
2008 |
|
Psoriasis
|
0.200 |
Biomarker
|
disease |
BEFREE |
IL-10 deregulation plays a role in the development of a large number of inflammatory diseases such as neuropathic pain, Parkinson's disease, Alzheimer's disease, osteoarthritis, rheumatoid arthritis, psoriasis, systemic lupus erythematosus, type 1 diabetes, inflammatory bowel disease, and allergy.
|
28799796 |
2019 |
|
Psoriasis
|
0.200 |
Biomarker
|
disease |
BEFREE |
This study suggests that different cytokines are players in the psoriasis pathogenesis although only the IL-10 family members IL-22 and IL-20 directly cause the characteristic epidermal alterations.
|
19330474 |
2009 |
|
Psoriasis
|
0.200 |
AlteredExpression
|
disease |
LHGDN |
In this review, we discuss recent knowledge about the effects of cytokines of the IL-10 family on keratinocytes and their potential role in psoriasis, a cutaneous inflammatory disease.
|
16464746 |
2005 |
|
Psoriasis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis shows that the IL-10-1082 G/A polymorphism confers susceptibility to psoriasis in Asians, and suggests that the IL-10 promoter -1082 polymorphism has an ethnicity-specific effect.
|
22427230 |
2012 |
|
Psoriasis
|
0.200 |
Biomarker
|
disease |
BEFREE |
Highlighting the role of IL-10 cytokine in the pathogenesis of psoriasis will help in the development of psoriasis management.
|
30147018 |
2019 |
|
Psoriasis
|
0.200 |
Biomarker
|
disease |
BEFREE |
Psoriasis-specific genes were important regulators of glucose and lipid metabolism, epidermal differentiation, as well as immune mediators of T helper 17 (TH17) responses, interleukin-10 (IL-10) family cytokines, and IL-36.
|
25009230 |
2014 |
|
Psoriasis
|
0.200 |
Biomarker
|
disease |
BEFREE |
To investigate polymorphisms in the genes for tumour necrosis factor alpha (TNFA), interleukin 10 (IL10) and tumour necrosis factor receptor II (TNFRII) in patients with psoriatic arthritis (PsA) and their relationship to the HLA-Cw*0602 allele and to the ages at onset of psoriasis and arthritis and the pattern of joint involvement.
|
12011375 |
2002 |
|
Psoriasis
|
0.200 |
Biomarker
|
disease |
BEFREE |
As ACC haplotype is suggested to be associated with high IL-10 secretion and ATA is related to low IL-10 secretion, potential differences in the IL-10 secretion levels might contribute the differences in the clinical course of psoriasis.
|
12944983 |
2003 |
|
Psoriasis
|
0.200 |
Biomarker
|
disease |
BEFREE |
Moreover, the number of cells positive for TGF-β was lower in DM than in psoriasis and AD, while IL-10(+) cells were significantly reduced only compared to psoriasis.
|
20843660 |
2010 |
|
Psoriasis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The present study concerned novel variants and other genetic polymorphisms of the promoter and exonic regions of the IL10 gene in patients with moderate to severe psoriasis and potential differences in genotype compared to a group of healthy volunteers.
|
25735363 |
2015 |
|
Psoriasis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Carriers of the IL10 T allele (rs1554286) and the IL20 T allele (rs1400986) conferred protection from psoriasis [odds ratio (OR) = 0·63, corrected P-value (Pc) = 0·007; OR = 0·62, Pc = 0·038, respectively].
|
28150860 |
2017 |
|
Psoriasis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The IL-10 promoter region contains a highly polymorphic microsatellite (IL10.G) and in a recent case-control study the IL10.G13 (144 bp) allele was found to be associated with familial early onset psoriasis (type 1 psoriasis) having a susceptible effect.
|
12932247 |
2003 |
|
Psoriasis
|
0.200 |
Biomarker
|
disease |
BEFREE |
Interleukin-22 (IL-22), an IL-10 family cytokines, is critical in the pathogenesis and development of psoriasis.
|
29181737 |
2018 |
|
Psoriasis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Three risk loci shared with ankylosing spondylitis and psoriasis (the MHC class I region, ERAP1 and IL23R and the MHC class I-ERAP1 interaction), as well as two loci shared with inflammatory bowel disease (IL23R and IL10) implicate shared pathogenic pathways in the spondyloarthritides and Behçet's disease.
|
23291587 |
2013 |