|
Psoriasis
|
0.200 |
Biomarker
|
disease |
BEFREE |
We investigated the main vascular and hypoxic controlling factors, which are vascular endothelial growth factor (VEGF) and hypoxia inducible factor 1 alpha (HIF-1α), as well as immunological and serotonergic factors, such as TNF-α, IL-10, and 5HT2A, which could connect each other to the pathogenesis of psoriasis.
|
31148856 |
2020 |
|
Psoriasis
|
0.200 |
Biomarker
|
disease |
BEFREE |
Regulatory B cells (Breg cells) producing IL-10 (B10 cells), a critical anti-inflammatory B-cell subset, were found to be decreased in both PsA and psoriasis.
|
31209492 |
2019 |
|
Psoriasis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
There was a highly significant association between psoriasis and cytokine levels with an effect size of 0.829 and a particularly strong impact on IL-2 (0.463), IL-12 (0.451), IL-10 (0.532) and adiponectin (0.401).
|
31062065 |
2019 |
|
Psoriasis
|
0.200 |
Biomarker
|
disease |
BEFREE |
IL-10 deregulation plays a role in the development of a large number of inflammatory diseases such as neuropathic pain, Parkinson's disease, Alzheimer's disease, osteoarthritis, rheumatoid arthritis, psoriasis, systemic lupus erythematosus, type 1 diabetes, inflammatory bowel disease, and allergy.
|
28799796 |
2019 |
|
Psoriasis
|
0.200 |
Biomarker
|
disease |
BEFREE |
Highlighting the role of IL-10 cytokine in the pathogenesis of psoriasis will help in the development of psoriasis management.
|
30147018 |
2019 |
|
Psoriasis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Current published studies fail to support an association of the IL-1RN VNTR polymorphism and IL-10 SNPs rs1800896, rs3021097, and rs1800872 with psoriasis risk.
|
30523673 |
2019 |
|
Psoriasis
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Pearson correlation analysis showed that plasma IL-35 expression negatively correlated with interferon-gamma, tumor necrosis factor-alpha, levels of IL-23, -17, and -22, or the Psoriasis Activity and Severity Index and positively correlated with levels of transforming growth factor beta and IL-10 levels in patients with psoriasis.
|
29802736 |
2018 |
|
Psoriasis
|
0.200 |
Biomarker
|
disease |
BEFREE |
Interleukin-22 (IL-22), an IL-10 family cytokines, is critical in the pathogenesis and development of psoriasis.
|
29181737 |
2018 |
|
Psoriasis
|
0.200 |
Biomarker
|
disease |
BEFREE |
In conclusion, IL-10 deficient mice model with imiquimod application may better reflect severe and persistent psoriasis with systemic inflammatory state.
|
28677206 |
2018 |
|
Psoriasis
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Mean serum IL-2, IFN-γ, and IL-10 levels of patients with psoriasis patients were significantly higher than the controls (P < 0.001 for both active and stable psoriasis), whereas mean serum IL-4 level of patients was significantly lower than the controls (P < 0.001).
|
29491194 |
2018 |
|
Psoriasis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
However, IL-10 (rs1800896) and FOXP3 (rs3761548) gene polymorphisms were not associated with psoriasis risk.
|
28027921 |
2017 |
|
Psoriasis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Carriers of the IL10 T allele (rs1554286) and the IL20 T allele (rs1400986) conferred protection from psoriasis [odds ratio (OR) = 0·63, corrected P-value (Pc) = 0·007; OR = 0·62, Pc = 0·038, respectively].
|
28150860 |
2017 |
|
Psoriasis
|
0.200 |
Biomarker
|
disease |
BEFREE |
In conclusion, IL-10+Breg cells are decreased PsA and Ps and inversely correlated with the severity of psoriasis and IL-17A+ and IFNγ+ T cells.
|
28461105 |
2017 |
|
Psoriasis
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
|
26974007 |
2016 |
|
Psoriasis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The present study concerned novel variants and other genetic polymorphisms of the promoter and exonic regions of the IL10 gene in patients with moderate to severe psoriasis and potential differences in genotype compared to a group of healthy volunteers.
|
25735363 |
2015 |
|
Psoriasis
|
0.200 |
Biomarker
|
disease |
BEFREE |
Psoriasis-specific genes were important regulators of glucose and lipid metabolism, epidermal differentiation, as well as immune mediators of T helper 17 (TH17) responses, interleukin-10 (IL-10) family cytokines, and IL-36.
|
25009230 |
2014 |
|
Psoriasis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
These results indicated that TNF-α-308 and IL-10-1082 polymorphisms imparted significant risk towards the development of psoriasis.
|
24594293 |
2014 |
|
Psoriasis
|
0.200 |
Biomarker
|
disease |
BEFREE |
Increasing evidence indicates that IL-10 plays an important role in both the onset and development of auto-immune diseases, such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), Sjogren's syndrome (SS), multiple sclerosis (MS), Crohn's disease (CD), and psoriasis.
|
24639111 |
2014 |
|
Psoriasis
|
0.200 |
Biomarker
|
disease |
BEFREE |
IL-20, a member of IL-10 family, is found to be involved in the development of psoriasis.
|
23892591 |
2014 |
|
Psoriasis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Three risk loci shared with ankylosing spondylitis and psoriasis (the MHC class I region, ERAP1 and IL23R and the MHC class I-ERAP1 interaction), as well as two loci shared with inflammatory bowel disease (IL23R and IL10) implicate shared pathogenic pathways in the spondyloarthritides and Behçet's disease.
|
23291587 |
2013 |
|
Psoriasis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis shows that the IL-10-1082 G/A polymorphism confers susceptibility to psoriasis in Asians, and suggests that the IL-10 promoter -1082 polymorphism has an ethnicity-specific effect.
|
22427230 |
2012 |
|
Psoriasis
|
0.200 |
Biomarker
|
disease |
BEFREE |
To evaluate circulating and lesional CD4(+) and CD8(+) cells belonging to Th1, Th2, and Th17 patterns as well as IL-10(+) cells before and after a 12-week lasting course with etanercept or acitretin in patients with psoriasis.
|
22699761 |
2012 |
|
Psoriasis
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Expression of galectin-1 correlated with IL-17 and IL-10 expression and with the psoriasis area and index activity.
|
22271227 |
2012 |
|
Psoriasis
|
0.200 |
Biomarker
|
disease |
BEFREE |
IL-20 is a proinflammatory cytokine of the IL-10 family that is involved in psoriasis, rheumatoid arthritis, atherosclerosis, and stroke.
|
21844205 |
2011 |
|
Psoriasis
|
0.200 |
Biomarker
|
disease |
BEFREE |
Moreover, the number of cells positive for TGF-β was lower in DM than in psoriasis and AD, while IL-10(+) cells were significantly reduced only compared to psoriasis.
|
20843660 |
2010 |