|
Hepatitis B
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that IL10 and IL20 gene variants influence HBV infection outcome and encourage the pursuit of further studies of these cytokines in HBV pathogenesis.
|
18479293 |
2008 |
|
Hepatitis B
|
0.100 |
Biomarker
|
disease |
BEFREE |
Whereas TBE and hepatitis B nonresponders had increased IL-10-producing FOXP3(+) T regulatory cells upon vaccination, only in hepatitis B nonresponders, showing elevated prevaccination IL-10 levels, a prominent population of B regulatory cells was detected.
|
23872054 |
2013 |
|
Hepatitis B
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Persistent HBV infection susceptibility is associated with the gene polymorphism IL-10 -1082GA in the Chinese population and the clearance of HBV is associated with the gene polymorphism IL-10 -592CA in the Chinese population.
|
21246248 |
2011 |
|
Hepatitis B
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Increased IL10 production mediated by IL10-ht2 suggests that up-regulated IL10 accelerates progression of chronic HBV infection, especially to HCC development.
|
12668613 |
2003 |
|
Hepatitis B
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
Evaluation of IL10, IL19 and IL20 gene polymorphisms and chronic hepatitis B infection outcome.
|
18479293 |
2008 |
|
Hepatitis B
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Genotypes A/A, A/G and G/G of IL-10-1082 were detected in CHB patients and individuals with self-limited HBV infection; however, genotype G/G had not been detected in normal controls.
|
27245049 |
2016 |
|
Hepatitis B
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
The IL-10 genotype (polymorphic bases at positions -1082 and -819) was determined in 272 chronic hemodialysis patients using highly specific PCR and related to the patients' response to a triple vaccination against hepatitis B. Secretion of IL-10 and IL-6 by peripheral blood leucocytes in vitro was determined by ELISA.
|
11737614 |
2001 |
|
Hepatitis B
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The presence of low producing IL-10-1082A and -592A alleles and their containing genetic variants protect highly exposed IDUs against acquisition of HIV and HBV infections.
|
25542814 |
2015 |
|
Hepatitis B
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The IL-10 promoter polymorphism at position -592 is correlated with susceptibility to occult HBV infection.
|
21901441 |
2012 |
|
Hepatitis B
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Moreover, there was a positive correlation between serum levels of IL-9 and IL-10 and HBV DNA loads in patients with chronic HBV infection.
|
28481430 |
2018 |
|
Hepatitis B
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition, the serum IL-10 were negatively correlated with the frequency of Th17 cells in PBMC from patients with chronic HBV infection (r=-0.452, P < 0.01).
|
20492330 |
2010 |
|
Hepatitis B
|
0.100 |
Biomarker
|
disease |
BEFREE |
Whether the same occurs during acute hepatitis B virus (HBV) infection and role that IL-10 might play in liver disease is currently unknown.
|
28483675 |
2017 |
|
Hepatitis B
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These data suggest that the frequencies of Bregs and levels of serum IL-10 were different in various immune phases in patients with chronic HBV infection.
|
28715645 |
2017 |
|
Hepatitis B
|
0.100 |
Biomarker
|
disease |
BEFREE |
The IL-10 gene promoter -592 C/C genotype was related to clearance of HBV infection in logistic regression analysis after adjusting for age and sex (P = 0.003).
|
16824070 |
2006 |
|
Hepatitis B
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We conducted a case-control study to investigate the role of three common single nucleotide polymorphisms of IL-10 (-592G/A, -819T/C, and -1082A/C) in the development of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC).
|
27050962 |
2016 |
|
Hepatitis B
|
0.100 |
Biomarker
|
disease |
BEFREE |
IL-10 may be an underlying predictor and treatment target of hepatitis B, and further studies are needed.
|
31725660 |
2019 |
|
Hepatitis B
|
0.100 |
Biomarker
|
disease |
BEFREE |
There was no difference in the HBV DNA levels during hepatitis flares between patients with genotypes B and C. Patients with genotype B had a significantly higher number of IFN-gamma producing cells [with hepatitis B core antigen (HBcAg) stimulation] and lower number of IL-10 producing cells (with HBcAg and HBeAg stimulation) compared with patients with genotype C (P = 0.011, =0.043, <0.001 respectively).
|
17381719 |
2007 |
|
Hepatitis B
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Tag single nucleotide polymorphisms (SNPs) were used to investigate the relationship between IL-10 gene polymorphisms and susceptibility to chronic hepatitis B virus (HBV) infection by comparing 996 chronic HBV infection cases to 301 acute infection controls.
|
24631780 |
2014 |
|
Hepatitis B
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These preliminary results suggest a strong association of IL10 (-819/-592) with the HBV infection mediated disease progression, from inactive carrier state to malignancy, in Indian population.
|
25027084 |
2014 |
|
Hepatitis B
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
IL-10 gene promoter polymorphisms significantly influence the mode and sequel of HBeAg seroconversion in patients with chronic HBV infection.
|
16584395 |
2006 |
|
Hepatitis B
|
0.100 |
Biomarker
|
disease |
BEFREE |
In contrast, the Th2 cytokine IL-10 serves as a potent inhibitor of Th1 effector cells in HBV diseases.
|
12679901 |
2003 |
|
Hepatitis B
|
0.100 |
Biomarker
|
disease |
BEFREE |
The IL-10 genotype (polymorphic bases at positions -1082 and -819) was determined in 272 chronic hemodialysis patients using highly specific PCR and related to the patients' response to a triple vaccination against hepatitis B. Secretion of IL-10 and IL-6 by peripheral blood leucocytes in vitro was determined by ELISA.
|
11737614 |
2001 |
|
Hepatitis B
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Risk for low anti-HBs titers decreased with concurrent decreases in glucose ante cibum (AC, before meals) and the IL-10 ACC/ACC haplotype.
|
21238445 |
2011 |
|
Hepatitis B
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To investigate the association of interleukin (IL)-10 and IL-10 receptor A (IL-10RA) single nucleotide polymorphisms with the responsiveness to hepatitis B virus (HBV) vaccination in newborns whose mothers were hepatitis B surface antigen (HBsAg)(+)/hepatitis B e antigen (HBeAg)(-).
|
30498038 |
2018 |
|
Hepatitis B
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The start of immune-clearance phase, age at HBeAg seroconversion, and serum IL-10 and IL-12 levels are associated with the course of the immune-clearance phase in chronic HBV infection, and are predictive of spontaneous HBsAg seroconversion and HBV recovery.
|
25505294 |
2015 |