|
Hepatitis B
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The relationship to the outcome of antiviral therapy for chronic HBV infection was studied in 24 patients who had a virologically sustained response(SR) and in 28 non-responder(NR) to interferon alfa-2b and several IL-10 variants were more frequent among SR compared with NR.
|
21251301 |
2011 |
|
Hepatitis B
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
When the results from each genotype were separately analyzed, the frequencies of the heterozygous CA (-592) and CT (-819) genotype of IL-10 gene-promoter polymorphisms were significantly higher in chronic HBV patients than that in healthy controls (OR=1.76, 9%CI =1.03-3.01, p =0.028; OR=1.79, 95%CI =1.04-3.06, p =0.024, respectively).
|
24383970 |
2013 |
|
Hepatitis B
|
0.100 |
Biomarker
|
disease |
BEFREE |
Depending on our preliminary work, IL-10 -1082G/G may act as a host genetic factor in the susceptibility to HBV infection in Egyptians.
|
24838671 |
2014 |
|
Hepatitis B
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Relationships between tumour necrosis factor-α, interleukin-12B and interleukin-10 gene polymorphisms and hepatitis B in Chinese Han haemodialysis patients.
|
22070668 |
2012 |
|
Hepatitis B
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms of IL-10 promoter in HBV and HCC patients may be associated with HBV infection and HCC development.
|
16481285 |
2006 |
|
Hepatitis B
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Influence of interleukin-10 gene promoter polymorphisms on disease progression in patients chronically infected with hepatitis B virus.
|
12190181 |
2002 |
|
Hepatitis B
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to determine the possible association of the three polymorphisms (A-1082G, T-819C, A-592C) in the IL-10 gene promoter with the susceptibility to hepatitis B virus (HBV)-related ALF in a Chinese population.
|
19413695 |
2009 |
|
Hepatitis B
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To explore the relationship between cytokines (tumor necrosis factor-alpha, interferon-gamma, interleukin-4 and interleukin-10), which expressed abnormal quantity in the peripheral blood to intrauterine hepatitis B virus infectious children, gene single nucleotide polymorphism (SNP) and susceptibility to hepatitis B virus intrauterine infection.
|
16232344 |
2005 |
|
Hepatitis B
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To elucidate the association between human interleukin-10 (IL-10) genotypes and hepatitis B virus (HBV) precore/core gene mutation in children with chronic HBV infection.
|
21168854 |
2011 |
|
Hepatitis B
|
0.100 |
Biomarker
|
disease |
BEFREE |
Genetic polymorphism in the cytokines TNF-alpha, IFN-gamma, TGF-beta1, IL-6, and IL-10 were studied in 236 Japanese patients with HBV infection.
|
15763337 |
2005 |
|
Hepatitis B
|
0.100 |
Biomarker
|
disease |
BEFREE |
Chronicity in hepatitis B virus (HBV) infection is maintained by increased type 2 T-helper cell response, possibly because of increased interleukin-10 (IL-10) productions.
|
17052271 |
2006 |
|
Hepatitis B
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
Polymorphisms in cytokine genes and their association with acute rejection and recurrence of hepatitis B in Chinese liver transplant recipients.
|
18375254 |
2008 |
|
Hepatitis B
|
0.100 |
Biomarker
|
disease |
BEFREE |
PD-1 expression was assessed by (1) flow cytometry and (2) quantitative real-time polymerase chain reaction; hepatitis B virus (HBV)-specific CD8+ T-cells were quantitated by pentamer staining; T-cell reactivity to HBV antigens was determined by interferon gamma (IFNgamma) and interleukin 10 (IL-10) enzyme-linked immunosorbent spot (ELISPOT) assays; and central/effector memory phenotypes were defined by phenotypic markers.
|
18697210 |
2008 |
|
Hepatitis B
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A recent genome-wide association study discovered that two polymorphisms, interferon (IFN) alpha receptor 2 (IFNAR-2) F8S and interleukin 10 receptor (IL10RB) K47E, were associated with susceptibility to hepatitis B virus (HBV) infection in Africa.
|
19714778 |
2009 |
|
Hepatitis B
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our meta-analysis supports the growing body of evidence that the presence of the IL10 -819 C/T polymorphism is associated with persistent HBV infection and that the -1082A/-819T/-592A haplotype and the -1082A/-819C/-592C haplotype are associated with HBV disease progression in Asians.
|
25583543 |
2015 |
|
Hepatitis B
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Serum levels of interleukin-10 and interleukin-12 predict early, spontaneous hepatitis B virus e antigen seroconversion.
|
19782084 |
2010 |
|
Hepatitis B
|
0.100 |
Biomarker
|
disease |
BEFREE |
To analyze the potential role of these cytokines in human fulminant hepatitis B, we used immunohistochemistry to study expression of IL-12, IFN-gamma, and IL-10 in explant livers of 11 patients with fulminant hepatitis B, 5 patients with fulminant hepatitis due to other etiologies, 37 patients with chronic liver disease (CLD; hepatitis B virus, n = 15; hepatitis C virus, n = 10; primary biliary cirrhosis, n = 12), and 10 normal controls (NCs).
|
12297850 |
2002 |
|
Hepatitis B
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This study demonstrated a significant association between the IL-10-592 A/C polymorphism and HBV infection in the Asian population under the overall effect size of allele A versus C. In our subgroup meta-analysis, we found a significant association of IL-10-592 A/C polymorphism to HCV infection susceptibility in Asian populations, although sensitivity analysis showed that the combined result was not associated with the worldwide population.
|
20529592 |
2010 |
|
Hepatitis B
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Association of the IFNAR1-17470 and IL-10-592 cytokine variants with susceptibility to chronic hepatitis B viral infections in a Chinese population.
|
25501140 |
2014 |
|
Hepatitis B
|
0.100 |
Biomarker
|
disease |
BEFREE |
Immunocompromized patients who are unresponsive to hepatitis B vaccination seem to be unable to enhance IL-10 synthesis for control of monokine overproduction.
|
7723241 |
1995 |
|
Hepatitis B
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
HBV employs hepatitis B surface antigen (HBsAg) to induce suppressive monocytes with HLA-E, PD-L1, IL-10 and TGF-β expression via the MyD88/NFκB signalling pathway.
|
28899983 |
2018 |
|
Hepatitis B
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We investigated the serum levels of interleukin (IL)-6, IL-10, IL-12, and interferon (IFN)-gamma in HBV-infected Vietnamese patients to determine whether they were related to the outcome of HBV infection.
|
12927756 |
2003 |
|
Hepatitis B
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The results demonstrate that IL-10 gene polymorphism can affect the outcome of chronic HBV infection.
|
16441483 |
2006 |
|
Hepatitis B
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here, we examined the relations between furin, IL-10, IL-12β, interferon (IFN)-γ, programed death (PD)-1, programed death ligand (PD-L)1, and the suppression of hepatitis B e antigen (HBeAg) and surface antigen (HBsAg) biosynthesis.
|
22634051 |
2012 |