|
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Gene polymorphisms of TNF-alpha-308 (G/A), IL-10(-1082) (G/A), IL-6(-174) (G/C) and IL-1Ra (VNTR) in Egyptian cases with type 1 diabetes mellitus.
|
19127455 |
2009 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
This study demonstrates that a number of the candidate genes previously associated with human T1D also appear to be associated with canine diabetes and identifies an IL-10 haplotype which is associated with diabetes in the Cavalier King Charles Spaniel.
|
17611256 |
2007 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Functional genetic polymorphisms of proinflammatory (T-helper-1: IL-2, IL-12 and IFN-gamma), anti-inflammatory (T-helper-2: IL-4, IL-6 and IL-10) and metabolic (IGF-I, VDR and INS) genes were determined in 206 Dutch simplex families with juvenile onset T1D and the results were analysed using the transmission disequilibrium test.
|
14735147 |
2004 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Autoantibodies to insulin (IAA), GAD (GADA), insulinoma-associated antigen-2 (IA-2A) and zinc transporter 8 (ZnT8A) were measured in follow-up sera, and genotyping for type 1 diabetes susceptibility genes (HLA-DR/HLA-DQ, INS variable number of tandem repeats [VNTR] and single nucleotide polymorphisms at PTPN22, PTPN2, ERBB3, IL2, SH2B3, CTLA4, IFIH1, KIAA0350 [also known as CLEC16A], CD25, IL18RAP, IL10, COBL) was performed on the DNA samples of children born to a parent with type 1 diabetes and prospectively followed from birth for up to 22 years.
|
23539116 |
2013 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Additionally, we show that T1D risk alleles residing at the PTPN22, IL27, IL18RAP and IL10 loci protect against CD.
|
20176734 |
2010 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
There were no differences of IL-10-592 genotype and allele frequencies between controls and type I diabetes.
|
11821159 |
2002 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that the IL-10 gene promoter polymorphisms are associated with the age-at-onset in Japanese patients with type 1 diabetes.
|
12121678 |
2002 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In fact, this is the first association study investigating the role of the IL- 10 polymorphisms in susceptibility to T1D in a Caucasian population.
|
15057267 |
2004 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Functional implications were assessed for variable sites in the 3'-UTR of T1D candidate risk genes CTLA4 and IL10, both involved in immune regulation.
|
22932817 |
2013 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, IL-10 promoter gene variants may contribute, but to a minor extent, to disease susceptibility in juvenile type 1 diabetes and should not be included in the routine genetic screening of high-risk individuals.
|
16720211 |
2006 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Children of parents with type 1 diabetes and prospectively followed from birth for the development of islet autoantibodies and diabetes were genotyped for single-nucleotide polymorphisms at 12 type 1 diabetes susceptibility genes (ERBB3, PTPN2, IFIH1, PTPN22, KIAA0350, CD25, CTLA4, SH2B3, IL2, IL18RAP, IL10 and COBL).
|
22932816 |
2012 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that IL-10 gene promoter region polymorphisms are not associated with genetic susceptibility to type 1 diabetes and AITD.
|
14679088 |
2003 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci.
|
21980299 |
2011 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
Biomarker
|
disease |
LHGDN |
The effect of LPS on neutrophils from patients with high risk of type 1 diabetes mellitus in relation to IL-8, IL-10 and IL-12 production and apoptosis in vitro.
|
11896938 |
2002 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
Biomarker
|
disease |
BEFREE |
However, addition of anti-IL-7Rα antibodies to peptide/alum vaccination unexpectedly increased non-specific IFN-γ, IL-2 and IL-10 cytokine production and did not result in improved prevention of T1D onset.
|
30908554 |
2019 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
Biomarker
|
disease |
BEFREE |
Type-I Interferons Inhibit Interleukin-10 Signaling and Favor Type 1 Diabetes Development in Nonobese Diabetic Mice.
|
30061883 |
2018 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
Biomarker
|
disease |
LHGDN |
In fact, this is the first association study investigating the role of the IL- 10 polymorphisms in susceptibility to T1D in a Caucasian population.
|
15057267 |
2004 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
Biomarker
|
disease |
BEFREE |
Cytokines such as interleukin (IL)-4, IL-10, and transforming growth factor (TGF)-β also play an important role in protection from T1D.
|
30758662 |
2019 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
Biomarker
|
disease |
BEFREE |
These results suggest that pSI-IL-10-NFkappaB with PEI can effectively reduce the incidence of insulitis and type 1 diabetes in NOD mice.
|
17130572 |
2006 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
Biomarker
|
disease |
BEFREE |
The study identifies a region of IA-2 frequently recognised by antibodies in Type 1 diabetes and demonstrates that these responses are associated with T-cells secreting IL-10 in response to a neighbouring determinant.
|
19447008 |
2009 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
Biomarker
|
disease |
BEFREE |
This suggested that T1DM susceptibility in Nod2<sup>-/-</sup>NOD mice is dependent on the alteration of gut microbiota, which modulated the frequency and function of IgA-secreting B-cells and IL-10 promoting T-regulatory cells.
|
28592385 |
2017 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
Biomarker
|
disease |
BEFREE |
This vaccine immunized into prediabetic NOD mice subcutaneously could induce IL-10 and TGF-β expressing pTregs and lead to suppressing autoreactive T cells responses, resulting in the prevention of T1D in these animals.
|
31070990 |
2020 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
Biomarker
|
disease |
BEFREE |
Simultaneous presence of TNF-alpha-308 GA + AA along with high secretor genotypes of IL-6 (P < 0.0001, OR = 2.61, 95% CI = 1.5-4.56), IL-10 (P < 0.0001, OR = 4.26, 95% CI = 1.9-10.1) and TGF-beta1 (P < 0.00004, OR = 2.8, 95% CI = 1.6-4.86) was also significantly increased in patients with T1D.
|
17498265 |
2007 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
Biomarker
|
disease |
BEFREE |
However, the Treg cells showed a decreased production of anti-inflammatory (IL-10, IL-35, TGF-β) and increased pro-inflammatory (IFN-γ, IL-2, IL-17) cytokines, indicating a phenotypic shift of Treg cells under T1D condition.
|
26224624 |
2015 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
Biomarker
|
disease |
BEFREE |
T cells secreting the cytokines IFN-γ and IL-10 in response to seven peptides known to elicit T cell responses in type 1 diabetes were quantified by cytokine ELISPOT in HLA-typed patients characterized for Abs to IA-2 epitopes.
|
25225671 |
2014 |