|
Asthma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Secondary outcomes were asthma control test (ACT) scores, fractional exhaled nitric oxide (FeNO), interleukin-10 (IL-10) and adverse events.
|
30961957 |
2019 |
|
Asthma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
We aimed to determine the effect of exercise on pro- and anti-inflammatory cytokine (TNF-α, IL-1ra, IL-10) and innate immunity protein (HSPA1, sCD14) levels in exhaled breath condensate (EBC) and nasal secretions of competitive athletes, non-exercising asthmatics and healthy controls (HC).
|
28822267 |
2018 |
|
Asthma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
However, the numbers of IL-10 and IL-12 mRNA(+) cells were increased in AA subjects compared with NAA, AC, and NC subjects (P <.05).
|
11031340 |
2000 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Therefore, we here developed a mouse model of asthma by microinjecting the pronucleus with a vector spontaneously coding human IL10 and TGFB1 gene to explore the possible interaction between these two potent molecules during asthma progression.
|
27696149 |
2016 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
At least one positive SNP with a TDT of p < 0.05 for asthma or total IgE and calcidiol or calcitriol was seen in IL10, GC, IL12B, CYP2R1, IL4R, and CYP24A1.
|
16600026 |
2006 |
|
Asthma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Additionally, IL-13, IL-10 and eosinophil major basic protein mRNA levels were greater in patients with asthma exacerbations compared to non-exacerbating patients (P = 0.03, P = 0.06 and P = 0.02, respectively), and IL-13 mRNA correlated with the peak Asthma Index (P = 0.006).
|
24450586 |
2014 |
|
Asthma
|
0.300 |
GeneticVariation
|
disease |
LHGDN |
IL-10(-1082(G-->A)) G/G and TNF-alpha-308(G-->A) G/G may be a contributing factor in susceptibility as well as severity of asthma among Egyptian children.
|
18534084 |
2009 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
However, the interactions between IL-10 and innate IFNs during virus-induced exacerbations of asthma have not been well studied.
|
25430775 |
2015 |
|
Asthma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in IL10 are associated with asthma phenotypes in this cohort.
|
14748015 |
2004 |
|
Asthma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Further, low-dose LPS (1 ug) exposure was associated with increased Th1 cytokines, T-bet, Treg cytokine (IL-10, TGF-β), and Foxp3 expression, but decreased Th2 cytokines (IL-4,5,13), GATA3, Th17, and ROR-gt expression compared with the asthma group.
|
29768397 |
2018 |
|
Asthma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The CC genotype of IL10 T-819C compared to the TT genotype may have a protective effect on asthma risk in younger adults (25-40 years old), and males in Taiwan.
|
26546526 |
2016 |
|
Asthma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Serum cytokine profiles with high levels of IL-1Ra and IL-10 were associated with lower subsequent risks of worsening asthma control and attacks in adults.
|
28340863 |
2017 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
IL-10(-1082(G-->A)) G/G and TNF-alpha-308(G-->A) G/G may be a contributing factor in susceptibility as well as severity of asthma among Egyptian children.
|
18534084 |
2009 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Asthma protection is not conferred by extracts from other enteropathogens and requires a heat-sensitive H. pylori component and the DC-intrinsic production of IL-10.
|
25074917 |
2014 |
|
Asthma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Combined effect of IL-10 and TGF-beta1 promoter polymorphisms as a risk factor for aspirin-intolerant asthma and rhinosinusitis.
|
19222424 |
2009 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Our results showed an association between IL-10 SNPs and mild asthma.
|
26108303 |
2015 |
|
Asthma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Reduction of respiratory infections in asthma patients supplemented with vitamin D is related to increased serum IL-10 and IFNγ levels and cathelicidin expression.
|
29402723 |
2018 |
|
Asthma
|
0.300 |
AlteredExpression
|
disease |
LHGDN |
Our findings suggest that dust mite allergen levels modify the effect of IL10 SNPs on allergy and asthma exacerbations and may partly explain conflicting findings in this field.
|
18440625 |
2008 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
RGD |
Reduced airway inflammation in CD26/DPP4-deficient F344 rats is associated with altered recruitment patterns of regulatory T cells and expression of pulmonary surfactant proteins.
|
20560982 |
2010 |
|
Asthma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Protective cytokine polymorphisms for BA for seven cytokine genotypes (IL-4 -1098/G:T, TNF- alpha -238/G:G, IL-2 -330/G:T, IL-4 -590/C:T, IFNgamma utr5644/A:T, IL-1beta +3962/C:T, IL-10 -1082/A:G), six cytokine diplotypes, four cytokine haplotypes, and four cytokine alleles were found.
|
18780949 |
2008 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
The allele and genotype frequencies of a number of polymorphic genes coding for IL-10, TGF-beta, IL-2, IL-12, and IFN-gamma were investigated in 60 patients with asthma in comparison with 140 controls.
|
18972297 |
2008 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Although IL-10-producing (IL-10+) T cells are detectable in the peripheral blood, their significance in the pathophysiology of asthma remains uncertain.
|
17396024 |
2008 |
|
Asthma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, the IL-4Ralpha +1902A/A and IL-1alpha -889C/C homozygous conditions and the TNF-alpha -308G/A, TNF-alpha -238G/A, IL-4 -590T/C and IL-10 -1082G/A heterozygous conditions were significantly associated with asthma (p less than 0.05).
|
23527710 |
2013 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
IL-10-differentiated dendritic cells (DC10) can reverse the asthma phenotype in mice, but how they suppress the asthmatic B cell response is unclear.
|
29293622 |
2018 |
|
Asthma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Two-gene models implicating functional variants in the IL10 and VDR genes as well as in the IL10 and IL1RL1 genes were associated with asthma (p < 0.0002).
|
19852851 |
2009 |