Asthma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Secondary outcomes were asthma control test (ACT) scores, fractional exhaled nitric oxide (FeNO), interleukin-10 (IL-10) and adverse events.
|
30961957 |
2019 |
Asthma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The combination of higher CG methylation levels of <i>LMO2_E148, IL10_P325</i> and <i>GSTM1_P266</i> corresponded to the highest risk of asthma.
|
31214241 |
2019 |
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Glucocorticoids are known to increase production of the anti-inflammatory cytokine IL-10, and this action is associated with their clinical efficacy in asthmatics.
|
30598515 |
2019 |
Asthma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Multivariate logistic regression analysis revealed that, at the initiation of dose reduction, the factors most predictive of maintenance of asthma control after ICS dose reduction were a low serum IL-33 level (P < .01), low PEF variability over 1 week (P = .014), childhood onset of asthma (at age <10 years) (P = .03), and high serum IL-10 level (P = .035).
|
29221918 |
2019 |
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Tumor-derived MDSCs inhibit airway remodeling in asthmatic mice through regulating IL-10 and IL-12.
|
31396328 |
2019 |
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
This study aims to investigate the role of IL-17A and IL-10 in predicting asthma control in case of Vit D supplementation.
|
31570180 |
2019 |
Asthma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
IL-10 rs1800896 gene polymorphism was associated with post-bronchiolitis asthma at 11-13 years of age in children hospitalised for bronchiolitis at less than six months of age.
|
31074014 |
2019 |
Asthma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
We aimed to determine the effect of exercise on pro- and anti-inflammatory cytokine (TNF-α, IL-1ra, IL-10) and innate immunity protein (HSPA1, sCD14) levels in exhaled breath condensate (EBC) and nasal secretions of competitive athletes, non-exercising asthmatics and healthy controls (HC).
|
28822267 |
2018 |
Asthma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Further, low-dose LPS (1 ug) exposure was associated with increased Th1 cytokines, T-bet, Treg cytokine (IL-10, TGF-β), and Foxp3 expression, but decreased Th2 cytokines (IL-4,5,13), GATA3, Th17, and ROR-gt expression compared with the asthma group.
|
29768397 |
2018 |
Asthma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Reduction of respiratory infections in asthma patients supplemented with vitamin D is related to increased serum IL-10 and IFNγ levels and cathelicidin expression.
|
29402723 |
2018 |
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
IL-10-differentiated dendritic cells (DC10) can reverse the asthma phenotype in mice, but how they suppress the asthmatic B cell response is unclear.
|
29293622 |
2018 |
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
The results showed promoting effects of auraptene on T cell subsets toward Th<sub>1</sub> (IFN-γ) and T<sub>reg</sub> (IL-10), which suggest its therapeutic value for treatment of Th<sub>2</sub> cells predominant diseases including allergic disease such as asthma and atopic dermatitis as well as cancers.
|
29747740 |
2018 |
Asthma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
DFSCs decreased IL-4 and GATA3 expression and increased IFN-γ, T-bet and IL-10 expression in asthmatics.
|
29498435 |
2018 |
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
In addition, similar IL-10-mediated regulation on Treg cells was also confirmed in the murine model of asthma.
|
28799262 |
2018 |
Asthma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
We used n-hexane fractionation to separate sea cucumber into three phases (n-hexane, alcohol, and solid) and evaluated the ability of each phase to elevate Il10 expression in splenocytes and ameliorate symptoms in mice with ovalbumin (OVA)/alum-induced asthma.
|
29161525 |
2018 |
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Moreover, IL-17A/IL-10 and RORγt/Foxp3 ratios, but not IL-4/IFN-γ or GATA-3/T-bet ratios, negatively correlated with forced expiratory volume in the first second (FEV<sub>1</sub>)/FEV<sub>1pred</sub> and Asthma Control Test Questionnaire (ACT) scores in both exacerbation group and non-exacerbation group.
|
30233198 |
2018 |
Asthma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Serum cytokine profiles with high levels of IL-1Ra and IL-10 were associated with lower subsequent risks of worsening asthma control and attacks in adults.
|
28340863 |
2017 |
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Interleukin-10 (IL-10) is an important regulatory cytokine required to control allergy and asthma.
|
27166557 |
2017 |
Asthma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
A 10 μg/m<sup>3</sup> increase of NO<sub>2</sub> exposure during infancy was associated with a 13.6% (95% confidence interval (CI): 0.8; 28.1%) increase in interleukin-6 (IL-6) levels, as well as with a 27.8% (95% CI: 4.6, 56.2%) increase in IL-10 levels, the latter limited to children with asthma.
|
28669936 |
2017 |
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Cytokine IL-10 also plays a nonredundant role in protection against allergic airway inflammation in asthma.
|
28689246 |
2017 |
Asthma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
In addition, interleukin 10, forkhead box P3 (Foxp3) and Treg levels in lymph, peripheral blood and lung tissue samples from asthma rats were increased significantly following hPMSC transplantation.
|
28944907 |
2017 |
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Studies suggest that helminth infections can activate a regulatory network characterized by the production of regulatory cytokines, such as interleukin 10 and transforming growth factor β1 (TGF-β1) and subsequently protect against immune-mediated diseases, such as asthma.
|
28284979 |
2017 |
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
The frequency and numbers of peripheral blood CD4+ interferon (IFN) gamma+ T-helper (Th) type 1, CD4+ IL-4+ Th2, CD4+ IL-17A+ Th17, CD4+CD25+ Forkhead Box P3+ regulatory T cells (Treg) and CD19+ IL-10+ Bregs in 22 children with asthma, 17 children with asthma and AR, and 25 healthy controls were determined by flow cytometry.
|
29046188 |
2017 |
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Therefore, we here developed a mouse model of asthma by microinjecting the pronucleus with a vector spontaneously coding human IL10 and TGFB1 gene to explore the possible interaction between these two potent molecules during asthma progression.
|
27696149 |
2016 |
Asthma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The CC genotype of IL10 T-819C compared to the TT genotype may have a protective effect on asthma risk in younger adults (25-40 years old), and males in Taiwan.
|
26546526 |
2016 |