IL10, interleukin 10, 3586

N. diseases: 1679; N. variants: 21
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0001339
Disease: Acute pancreatitis
Acute pancreatitis
0.100 Biomarker disease BEFREE A binomial logistic regression was performed to evaluate Ranson's criteria and IL6, IL8, and IL10 (at admission and after 48 hours) in the course of AP. 31242405 2020
CUI: C0001339
Disease: Acute pancreatitis
Acute pancreatitis
0.100 Biomarker disease BEFREE Serum IL-10 increased uniformly in AP, without any effect of preceding VR or VL. 30690339 2019
CUI: C0001339
Disease: Acute pancreatitis
Acute pancreatitis
0.100 Biomarker disease BEFREE We investigate the dynamic longitudinal changes in circulating IL-10-producing B cells (B10) and memory CD19<sup>+</sup>CD24<sup>hi</sup>CD27<sup>hi</sup> cells in patients with AP to evaluate their prediction utility for AP severity. 30546828 2018
CUI: C0001339
Disease: Acute pancreatitis
Acute pancreatitis
0.100 GeneticVariation disease BEFREE IL-10 gene rs1800896 polymorphism increases the risk of AP. 29310417 2017
CUI: C0001339
Disease: Acute pancreatitis
Acute pancreatitis
0.100 Biomarker disease BEFREE MS treatment reversed the increased serum level of amylase and lipase, alleviated the pathological damage in the pancreas, and decreased the expression of TNFα, IL-6, IFNγ and IL-10 in cerulean-induced AP mice. 28759809 2017
CUI: C0001339
Disease: Acute pancreatitis
Acute pancreatitis
0.100 GeneticVariation disease BEFREE In conclusion, this study demonstrates that the IL-10 -1082A/G gene polymorphism contributes to the development of acute pancreatitis. 27173345 2016
CUI: C0001339
Disease: Acute pancreatitis
Acute pancreatitis
0.100 GeneticVariation disease BEFREE In conclusion, IL-10 rs1800896 was correlated with an increased risk of acute pancreatitis in codominant, dominant, and recessive models. 26634555 2015
CUI: C0001339
Disease: Acute pancreatitis
Acute pancreatitis
0.100 GeneticVariation disease BEFREE In conclusion, we suggest that IL-10-1082A/G gene polymorphisms contribute to the development of acute pancreatitis in codominant, dominant and recessive models. 26823862 2015
CUI: C0001339
Disease: Acute pancreatitis
Acute pancreatitis
0.100 Biomarker disease BEFREE After 7 days the serum concentrations of IL-10 were higher in the EA group than in the control group (mild AP: 6.2±1.2 vs 5.2±0.9 pg/mL, p<0.05; severe AP: 14.9±7.8 vs 7.9±6.3 pg/mL, p<0.05). 25520280 2015
CUI: C0001339
Disease: Acute pancreatitis
Acute pancreatitis
0.100 GeneticVariation disease BEFREE We found that the IL-8 -251T/A polymorphism is associated with an increased risk of acute pancreatitis, and no significant association between IL-1βand IL-10 gene polymorphisms and risk of acute pancreatitis was detected. 26125871 2015
CUI: C0001339
Disease: Acute pancreatitis
Acute pancreatitis
0.100 GeneticVariation disease BEFREE However, we found no significant association between IL-1β +3954 C/T, IL-1β -511 C/T, IL-6 -174 G/C, IL-6 -174 G/C, IL-6 -634 C/G, IL-10 -1082A/G, or IL-10 -819C/T polymorphisms and risk of acute pancreatitis. 25730090 2015
CUI: C0001339
Disease: Acute pancreatitis
Acute pancreatitis
0.100 GeneticVariation disease BEFREE However, there were no significant associations between IL-1β (IL-1β +3954 C/T (rs1143634) and IL-1β -511 C/T (rs16944)), IL-6 (IL-6 -174 G/C (rs1800795) and IL-6 -634 C/G (rs1800796)) and IL-10 (IL-10 -1082 A/G (rs1800896), IL-10 -819 C/T (rs1800871) and IL-10 -592 C/A (rs1800872)) gene polymorphisms and AP risk. 24072654 2013
CUI: C0001339
Disease: Acute pancreatitis
Acute pancreatitis
0.100 Biomarker disease BEFREE Tumor necrosis factor-α and interleukin-10 contribute to immunoparalysis in patients with acute pancreatitis. 20937337 2011
CUI: C0001339
Disease: Acute pancreatitis
Acute pancreatitis
0.100 AlteredExpression disease BEFREE This article investigates the relationship between different polymorphisms of tumor necrosis factor alpha (TNF-alpha), interleukin 1 (IL-1), IL-1 receptor antagonist, IL-6, and IL-10 with the severity and etiology of AP and the serum levels of the cytokine encoded. 18815552 2008
CUI: C0001339
Disease: Acute pancreatitis
Acute pancreatitis
0.100 AlteredExpression disease BEFREE The purpose of this study was to evaluate the ability to transfect a murine pancreas with a human cytokine regulatory gene (interleukin-10 [IL-10]) and examine the duration of transgene expression, its effect on the normal pancreas, and its antiinflammatory effect during acute pancreatitis. 9637544 1998