|
Ulcerative Colitis
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Systemic molecular mediators of inflammation differentiate between Crohn's disease and ulcerative colitis, implicating threshold levels of IL-10 and relative ratios of pro-inflammatory cytokines in therapy.
|
31241755 |
2020 |
|
Ulcerative Colitis
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
It is found that the anti-UC activities are mainly focused on targeting inflammation or oxidative stress, which is associated with increasing the levels of anti-inflammatory cytokine (IL-4, IL-10, SOD), suppressing the levels of pro-inflammatory cytokines (TNF-α, IL-1β, IL-6, IL-8, IL-23, NF-κB, NO), reducing the activity of MPO, MDA, IFN-γ, and iNOS.
|
30797423 |
2019 |
|
Ulcerative Colitis
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Moreover, CA decreased the pro-inflammatory cytokines and NLRP3 inflammasome, miR-21 and miR-155 in colon tissues, in addition, the percentage of macrophages was reduced based on the surface marker F4/80 and IL-10 secretion in CA-treated group, suggesting that the CA ameliorate the UC via activation of macrophage.
|
30530166 |
2019 |
|
Ulcerative Colitis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Based on our results, smoking has a positive influence on cessation and the clinical course of UC due to the stimulation of anti-inflammatory cytokine IL 10 in mucosa.
|
31842582 |
2019 |
|
Ulcerative Colitis
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
The levels of IL-6 and TNF-α in peripheral blood in the UC patient group were significantly increased compared with those in the healthy adult group (P<0.01), while the levels of IL-10 and IL-4 in peripheral blood were significantly decreased compared with those in the healthy adult group (P<0.01).
|
30906432 |
2019 |
|
Ulcerative Colitis
|
0.500 |
Biomarker
|
disease |
BEFREE |
The TLR9 agonist cobitolimod induces IL10 producing wound healing macrophages and regulatory T cells in ulcerative colitis.
|
31630153 |
2019 |
|
Ulcerative Colitis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Local dominance of Gal-3 and IL-10 over pro-inflammatory mediators in patients with MetS may present a mechanism for limiting the inflammatory process and subsequent tissue damage in UC.
|
31798282 |
2019 |
|
Ulcerative Colitis
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Compared with that in the DSS group, FMT ameliorated the severity of inflammation due to ulcerative colitis in mice, which was accompanied by a significantly decreased MPO activity, reduced levels of TNF-α and IL-1β, and an increased level of IL-10 in colon tissue (all P<0.05).
|
30906449 |
2019 |
|
Ulcerative Colitis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Inhibition of tumor necrosis factor alpha and increased of interleukin 10 by <i>Lactobacillus</i>: a molecular mechanism protection against TNBS-induced ulcerative colitis in chicks.
|
30821556 |
2019 |
|
Ulcerative Colitis
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Intracellular IL-10 expression by CD4<sup>+</sup> T-cell subsets in the inflamed guts of patients with IBD (Crohn disease or ulcerative colitis) was compared with that in cells from noninflamed control subjects.
|
29369775 |
2018 |
|
Ulcerative Colitis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Pathologically, Erbin expression in the intestinal mucosa was significantly decreased in DSS induced acute colitis mice, IL-10 deficient mice and clinical biopsy specimens from patients with ulcerative colitis.
|
29552291 |
2018 |
|
Ulcerative Colitis
|
0.500 |
Biomarker
|
disease |
BEFREE |
TNFα tended to negatively correlate with CD14+PLT+ in relapse and inactive UC patients, whereas IL-10 positively correlated with CD14+PLT+ in all UC patients (r = -0.43, P = 0.1 and r = 0.61, P = 0.01, respectively).
|
29529212 |
2018 |
|
Ulcerative Colitis
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Both CD and UC samples exhibited gene and protein expression of HLA-G; and the HLA-G5 expression is differentially correlated with TNF and IL-10 levels depending on the type of the underlying inflammatory bowel disorder.
|
29588183 |
2018 |
|
Ulcerative Colitis
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
SP8 could also reduce the levels of TNF-α, IL-1β, IL-6, MPO and MDA and increase the levels of IL-4 and IL-10 in colon tissue of UC mice in comparison with those of the model group (p<0.05).
|
28284792 |
2017 |
|
Ulcerative Colitis
|
0.500 |
Biomarker
|
disease |
BEFREE |
In situ hybridization targeting the GH receptor (GHR) and relevant transcriptional analyses were performed in patients with UC and in IL-10 knock-out mice with piroxicam accelerated colitis (PAC).
|
28946616 |
2017 |
|
Ulcerative Colitis
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, administration of DSS at 1.25 g/kg BW for 10 days respectively induced acute inflammation in the jejunum and chronic inflammation and ulcerative colitis in the colon with substantially decreased colonic concentration and mRNA abundance of IL-10 in the young pigs, mimicking the IL-10 expression pattern in humans Associated with chronic bowel inflammation.
|
27782738 |
2017 |
|
Ulcerative Colitis
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
|
26974007 |
2016 |
|
Ulcerative Colitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
No association was observed between rs3024505 and UC or SNPs in IL10 promoter region and any form of IBD.
|
27558476 |
2016 |
|
Ulcerative Colitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We confirmed the associations of 10 known UC risk loci in Koreans: rs76418789 in IL23R (combined P = 1.25 × 10), rs4728142 in IRF5 (combined P = 3.17 × 10), rs1830610 near JAK2 (combined P = 2.28 × 10), rs1555791 near TNFRSF14 (combined P = 1.62 × 10), rs880790 between IL10-IL19 (combined P = 3.73 × 10), rs10185424 between IL1R2-IL1R1 (combined P = 1.54 × 10), rs6478108 in TNFSF15 (combined P = 9.28 × 10), rs861857 between UBE2L3-YDJC (combined P = 3.05 × 10), rs1801274 in FCGR2A (discovery P = 1.54 × 10), and rs17085007 between GPR12-USP12 (discovery P = 3.64 × 10).
|
26398853 |
2016 |
|
Ulcerative Colitis
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Significantly lower levels of IL-10 and IL-35 were observed in Treg cultures of UC patients. miR-21, miR-146a, and miR-155 levels were downregulated and miR-31 level was upregulated in Tregs of patients.
|
26730791 |
2016 |
|
Ulcerative Colitis
|
0.500 |
Biomarker
|
disease |
BEFREE |
These results suggest that p38 MAPK-mediated synergism between IL-10 and glucocorticoids improves desmosome straightness contributing to the recovery of intestinal epithelium and reducing luminal antigens contact with lamina propria in ulcerative colitis.
|
26090671 |
2015 |
|
Ulcerative Colitis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Serotonin (5-HT) release and serotonin reuptake transporter (5-HTT) expression have been reported to be decreased in experimental colitis, in interleukin-10 knockout-associated colitis, and in patients with ulcerative colitis.
|
25532499 |
2015 |
|
Ulcerative Colitis
|
0.500 |
Biomarker
|
disease |
BEFREE |
IL-33 is upregulated in ulcerative colitis (UC), and the aim was to assess if IL-33 holds a similar key position in the shaping of the immune response in experimental colitis (piroxicam-accelerated colitis (PAC) in IL-10 (-/-) mice, dextran sodium sulfate (DSS) model) and UC.
|
25112700 |
2015 |
|
Ulcerative Colitis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Relatively low IL-10 in patients with severe UC is insufficient to compensate IL-6 secretion and subsequently enhanced type 1/17 immune response.
|
25076849 |
2014 |
|
Ulcerative Colitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to assess the association of polymorphisms in the promoter region of the IL-10 gene with the risk of inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC).
|
24407599 |
2014 |