|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
<b>Objective:</b> The association of interleukin-10 (IL-10) polymorphism with diabetes and its complication was recently established, while there were few researches considering the potential role of IL-10 in gestational diabetes (GDM).
|
30873205 |
2019 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
On the other hand, significant elevations of serum Reg2 antibody and splenic CD4+/IFN-γ+ T cells, and decreases in serum IL-4 and IL-10 were detected in rReg2-vaccinated mice, which may contribute to the accelerated diabetes.
|
30690849 |
2019 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Interestingly, two doses of vaccine (PPI+TGFβ+IL10) combined with a sub-therapeutic dose of anti-CD3 prevented diabetes and decreased hyperglycemia in mice.
|
30416020 |
2018 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here we show that a combination therapy of low-dose anti-CD3 with a clinical-grade self-containing L. lactis, appropriate for human application, secreting human proinsulin and interleukin-10, cured 66% of mice with new-onset diabetes, which is comparable to therapy results with plasmid-driven L. lactis Initial blood glucose concentrations (<350 mg/dL) and insulin autoantibody positivity were predictors of the stable reversal of hyperglycemia, and decline in insulin autoantibody positivity was an immune biomarker of therapeutic outcome.
|
28108611 |
2017 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Pancreatic IL-2Rβ<sup>Y3</sup> T<sub>regs</sub> showed impaired development into IL-10-secreting effector T<sub>regs</sub> The pancreatic lymph nodes and pancreases of NOD-Y3 mice had increased numbers of antigen-experienced CD4<sup>+</sup> effector T cells, which was largely due to impaired T<sub>regs</sub>, because adoptively transferred pancreatic autoantigen-specific CD4<sup>+</sup> Foxp3<sup>-</sup> T cells from NOD-Y3 mice did not accelerate diabetes in NOD.SCID recipients.
|
29259102 |
2017 |
|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In multivariable analysis adjusting for age, sex, diabetes and renal disease, the adjusted OR for 28-day mortality in carriers of the variant was 0.24 (95% CI 0.05-1.08, P = 0.06); and the adjusted OR for 90-day mortality was 0.27 (95% CI 0.08-0.97, P = 0.04). c.1174C>T was associated with a lower rate of bacteremia (P = 0.04) and reduced plasma levels of IL-10 (P = 0.049) and TNF-α (P < 0.0001).
|
28475641 |
2017 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Moreover, depletion of CD4(+) CD25(+) T cells using magnetic-activated cell sorting impaired the protective effect of SGAD65190-315 /IL-10 vaccination on adoptive transfer of diabetes.
|
26797873 |
2016 |
|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
After adjustment in the multivariate regression analysis, the following variables remained significantly associated with HCC-HCV occurrence: diabetes (p=0.012 OR 10.44 CI 1.66-65.60), IL-10 lower levels (p<0.0001 OR 0.83 CI 0.78-0.89) and TNF-α higher levels (p<0.0001 OR 1.19 CI 1.11-1.28).
|
23602201 |
2013 |
|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The IL-10 (-1082G/A) genotype and allele frequencies were not different between patients with diabetes with nephropathy and those without nephropathy.
|
21861711 |
2012 |
|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Results of this study suggest that the functional gene polymorphism of IL-10 reported here may play an important role in the pathogenesis of diabetes, but it seems that these polymorphisms do not have an effect on the nephropathic complications of the disease.
|
21909800 |
2012 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Glyphosine, a pocket 9 compound, enhances insulin peptide presentation to T cells at concentrations as low as 10 nM, upregulates IL-10 secretion, and prevents diabetes in NOD mice.
|
22043012 |
2011 |
|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Statistical analysis of genotype frequencies made separately for the underlying renal disease (diabetes or glomerulo-nephritis) revealed the same linkage trend: TGF-beta 1 (codon 10) TT and IL-10 (-1082) GG were associated with type 2 diabetic nephropathy (p<0.001 and p<0.05, respectively) and chronic glomerulonephritis (p<0.001 and p<0.01, respectively).
|
17173255 |
2007 |
|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This study demonstrates that a number of the candidate genes previously associated with human T1D also appear to be associated with canine diabetes and identifies an IL-10 haplotype which is associated with diabetes in the Cavalier King Charles Spaniel.
|
17611256 |
2007 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Similar to what is observed in elderly individuals, low IL-10 production is associated with diabetes in antiviral-treated HIV infection.
|
16437243 |
2006 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
The serum glucose levels showed that single injection of pSI-IL-10-NFkappaB prevented the development of diabetes in 100% of the pSI-IL-10-NFkappaB-injected animals (5/5), while that of pSI-IL-10 prevented diabetes in 40% of the treated animals (2/5).
|
17130572 |
2006 |
|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our study suggests that IL-10 genetic polymorphisms may play a specific role(s) in determining diabetic susceptibility, but do not seem to be important in the clinical manifestations of diabetes.
|
16690414 |
2005 |
|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Since interleukin-10 (IL-10) modulates immune and inflammatory responses and has been implicated in many autoimmune diseases, it seemed interesting to examine whether IL-10 polymorphisms participate in diabetes predisposition.
|
15057267 |
2004 |
|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that the G/A mutation at position -1082 of IL-10 promoter gene region might be one of the factors participating to the pathogenesis of LADA diabetes and that identification of cytokine gene polymorphisms might contribute to the characterization of the different types of diabetes mellitus.
|
15622443 |
2004 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our data suggest that cyclophosphamide- but not IL-10-induced diabetes is Fas dependent.
|
10946317 |
2000 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Because exogenous IL-4 and IL-10 exert antidiabetogenic effect in NOD mice and early blockade of endogenous tumor necrosis factor-alpha prevents NOD mouse diabetes, these phenomena may be causally related to the antidiabetogenic effect of HGG-pulsed DC treatment.
|
10746656 |
2000 |