Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Collectively, this meta-analysis proved that IL-2 rs2069762, IL-4 rs2243250, IL-6 rs1800795, IL-8 rs4073, IL-10 rs1800871 and IL-10 rs1800896 polymorphisms may confer susceptibility to TB, especially for Asians.
|
31669382 |
2020 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Using in vitro and ex vivo cell culture systems, we show that human M(IL-10) anti-inflammatory macrophages, present in TB-associated microenvironment, produce high levels of HIV-1.
|
30917314 |
2019 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our findings strongly indicate that IAV coinfection compromises the host's ability to control Mtb infection via the production of IL-10 which was rapidly induced upon viral infection.
|
30998505 |
2019 |
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Collectively, this meta-analysis proved that IL-6 rs1800795, IL-8 rs4073, IL-10 rs1800871, IL-10 rs1800872 and IL-10 rs1800896 may confer susceptibility to TB.
|
31560754 |
2019 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here, we show that pulmonary BCG prevents infection by using a repeated limiting-dose Mycobacterium tuberculosis challenge model and identify polyfunctional T-helper type 17 (T<sub>H</sub>17) cells, interleukin-10 and immunoglobulin A as correlates of local protective immunity.
|
30664782 |
2019 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our data demonstrated that IL-2, IL-6, IL-10, and IFN-γ may be useful in the auxiliary diagnosis of tuberculosis and as biomarkers for distinguishing LTBI from TB.
|
31012357 |
2019 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Neutrophils can express cytokines that influence TB progression, and so we compared neutrophil and T-cell expression of the Th1 cytokines IFNγ and TNF, the Th2 cytokine IL-4, and regulatory cytokine IL-10 in M. tuberculosis-infected macaques to determine if neutrophil cytokine expression contributes to dysregulated immunity in TB.
|
31434990 |
2019 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
To increase our understanding of immune response to M. tuberculosis infection, we conducted a cross-sectional study investigating M. tuberculosis infection status and comparing the release profiles of cytokines GM-CSF, IFN-γ, IL-1β, IL-10, IL-12 (p70), IL-2, IL-4, IL-5, IL-6, IL-8, TNF-α, in community controls (CCs) and healthy healthcare workers (HCWs) highly exposed to TB.
|
31160610 |
2019 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
IL-10 deficiency restored the type 1 immune response through DC activation, which provided better protection against TB infection.
|
31281230 |
2019 |
Tuberculosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Multivariate analysis identified an IL-6/IL-10 co-expression-based principal component in tuberculosis patients that correlated with high pSTAT3 levels.
|
30886421 |
2019 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
ELISA showed that interleukin (IL)-17, IL-6 and IL-10 in patients with HIV complicated with TB were significantly lower than in healthy subjects.
|
29456692 |
2018 |
Tuberculosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Moreover, we observed a positive correlation between the levels of IL-10 and the number of lipid-laden CD14<sup>+</sup> cells among the pleural cells in TB patients, demonstrating that FM differentiation occurs within the pleural environment.
|
29593722 |
2018 |
Tuberculosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Finally, we also measured the levels of IL-10 family cytokines in tuberculosis antigen (purified protein derivative, PPD) stimulated and unstimulated LN culture supernatants.
|
29871780 |
2018 |
Tuberculosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Multivariate analysis identified an IL-6/IL-10 co-expression-based principal component in tuberculosis patients that correlated with high pSTAT3 levels.
|
29553136 |
2018 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here we aimed to evaluate the mechanism of MTB infection in promoting interleukin-10 (IL-10) upregulation.
|
29523311 |
2018 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
IL10 inhibits the function of Th1 type cells, and IL10 deficiency has been associated with an improved resistance against Mycobacterium tuberculosis infection in a mouse model.
|
29985419 |
2018 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
This suggests that the IL-20 subfamily of cytokines, similar to IL-10 might play a potentially crucial role in the modulation of T cell responses in active TB disease.
|
29684756 |
2018 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The production of INF-γ but not IL-10 in the presence of purified protein, Rv0147, may be shifted to Th1 responses in MDR-TB patients and supports its potential as protein vaccine candidates against TB.
|
29178041 |
2018 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion, this study identifies a novel anti-inflammatory ISG15/IL-10 myeloid axis that is disrupted in active TB.
|
29311364 |
2018 |
Tuberculosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
IL-10 down-regulates the expression of survival associated gene hspX of Mycobacterium tuberculosis in murine macrophage.
|
28435012 |
2017 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Interestingly, both HIV-TB and HD showed a pronounced production of IFN-γ in uTreg population, though no significant differences were observed for IL-10 and TGF-β production between uTreg and cTreg.
|
28536578 |
2017 |
Tuberculosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Diminished levels of ESAT-6/CFP-10-induced IL-10 and increased levels of TB-antigen and LPS-stimulated sCD163 were found in childhood with pulmonary TB.
|
27685837 |
2017 |
Tuberculosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Cordyceps sinensis promotes immune regulation and enhances bacteriostatic activity of PA-824 via IL-10 in Mycobacterium tuberculosis disease.
|
28793052 |
2017 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our findings from a study of naturally infected human population suggest that IFN-γ, TNF-α and IL-10 against rESAT-6/CFP-10 are markers for clinical TB but not for protective immunity.
|
28374535 |
2017 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Together, our data reveal that, despite the multiple immune sources of IL-10 during <i>M. tuberculosis</i> infection, activated effector T cells are the major source accounting for IL-10-induced TB susceptibility.
|
28584007 |
2017 |