Kaplan-Meier survival analysis demonstrated that STAT3 phosphorylation, IL-10 expression and multiple brain lesions were significantly associated with PFS in PCNSL (P = 0.009, P = 0.030 and P = 0.040, respectively).
The present study evaluated 13 proteins individually-H-FABP, MMP-1, MMP-3, MMP-9, VCAM, ICAM, SAA, CRP, GSTP, NKDA, PRDX1, DJ-1 and IL-10-for their capacity to differentiate between patients with and without a brain lesion according to CT results.
These results identify CXCL13 and IL-10 as potentially important biomarkers of CNS lymphoma that merit further evaluation and support incorporation of CXCL13 and IL-10 into diagnostic algorithms for the workup of focal brain lesions in which lymphoma is a consideration.