IL10, interleukin 10, 3586
N. diseases: 1679; N. variants: 21
Source: ALL
| Disease | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year |
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0.100 | AlteredExpression | disease | BEFREE | In contrast, Lr-pulsed DC/CD4<sup>+</sup> T-cell co-cultures expressed low IL-10, high IL-12p70 and IFN-γ levels and declined Treg population; this responsiveness pattern was not changed by Hp. | 31328382 | 2019 |
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0.100 | GeneticVariation | disease | BEFREE | Polymorphisms of the IL-6, IL-8 and IL-10 genes and the risk of gastric pathology in patients infected with Helicobacter pylori. | 25888319 | 2017 |
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0.100 | AlteredExpression | disease | BEFREE | Hp GE-driven enhancement of lymphocyte cytotoxic activity was associated with the expansion of CD3(-)CD56(+)CD25(+) NK cells and the up-regulation of IFN-γ and/or IL-2 synthesis, up to the higher level in Hp(-) than in Hp(+), while Hp LPS-mediated decrease in lymphocyte cytotoxicity was accompanied by the lack of CD3(-)CD56(+)CD25(+) NK propagation, the inhibition of pro-inflammatory cytokine expression and intense expansion of IL-10-producing NK cells. | 24448078 | 2015 |
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0.100 | GeneticVariation | disease | BEFREE | Eight single nucleotide polymorphisms were associated with spontaneous production of IL-10 in culture, of which three (rs1800896 and rs1878672, p = .04; rs3024491, p = .01) were strongly associated with infection by Helicobacter pylori. | 24628819 | 2014 |
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0.100 | AlteredExpression | disease | BEFREE | Immunophenotype of peripheral blood natural killer cells and IL-10 serum levels in relation to Helicobacter pylori status. | 23758061 | 2013 |
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0.100 | Biomarker | disease | BEFREE | The effects of genetic polymorphisms of IL-6, IL-8, and IL-10 on Helicobacter pylori-induced gastroduodenal diseases in Korea. | 19077731 | 2009 |
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0.100 | Biomarker | disease | BEFREE | The local and systemic T-cell response to Helicobacter pylori in gastric cancer patients is characterised by production of interleukin-10. | 17826353 | 2007 |
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0.100 | GeneticVariation | disease | BEFREE | Sera were used for the measurement of pepsinogen (PG) and Helicobacter pylori CagA antibody (CagA-ab) levels by ELISA, and human genomic DNAs were used for the genotyping of interleukin (IL)-1beta (-511 and +3954), IL-10 (-1082 and -592), and IL-1RN intron 2 by PCR and RFLP. | 18086767 | 2007 |
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0.100 | GeneticVariation | disease | BEFREE | The IL-10-1082 (A/G)/-819 (T/C)/-592 (A/C) polymorphisms were assessed in Helicobacter pylori-positive patients with gastritis only (n = 162), gastric ulcers (n = 110), duodenal ulcers (n = 94), or gastric cancers (n = 105), and H. pylori-negative controls (n = 168) by allele specific primer-polymerase chain reaction methods. | 17716348 | 2007 |
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0.100 | GeneticVariation | disease | BEFREE | The aim of this study was to evaluate whether there was any correlation between Helicobacter pylori-associated diseases and (1) H. pylori virulence genes or (2) IL-1B, IL-1RN, IFN-G, TNF-A, IL-10 genetic polymorphisms. | 15652446 | 2005 |
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0.100 | Biomarker | disease | BEFREE | Eradication of Helicobacter pylori and resolution of gastritis in the gastric mucosa of IL-10-deficient mice. | 16181351 | 2005 |
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0.100 | GeneticVariation | disease | BEFREE | This study examined associations between anti-Helicobacter pylori immunoglobulin G antibody seropositivity and functional polymorphisms of interleukin-8 T-251 A and interleukin-10 T-819C. | 12662377 | 2003 |
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0.100 | AlteredExpression | disease | BEFREE | Helicobacter pylori (HP) infection induces expression of IL-8 and IL-10 in benign gastric epithelium. | 12218451 | 2002 |
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0.100 | AlteredExpression | disease | BEFREE | Increased expression of IL-10 and IL-12 (p40) mRNA in Helicobacter pylori infected gastric mucosa: relation to bacterial cag status and peptic ulceration. | 10655986 | 1999 |
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0.100 | AlteredExpression | disease | BEFREE | Expression of mRNA for interferon-gamma, interleukin-10, and interleukin-12 (p40) in normal gastric mucosa and in mucosa infected with Helicobacter pylori. | 9018762 | 1997 |
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0.100 | Biomarker | disease | BEFREE | Differential stimulation of interleukin-12 (IL-12) and IL-10 by live and killed Helicobacter pylori in vitro and association of IL-12 production with gamma interferon-producing T cells in the human gastric mucosa. | 9317031 | 1997 |