IL10, interleukin 10, 3586
N. diseases: 1679; N. variants: 21
Source: ALL
| Disease | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year |
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0.100 | Biomarker | disease | BEFREE | In addition, MIF is important for the release of TNF-α, MCP-1 and IL-10 triggered by RSV in macrophages. | 30944975 | 2019 |
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0.100 | Biomarker | disease | BEFREE | RSV disease was associated with a great regulatory cytokine response than healthy children, among 89 RSV-infected patients, serum IL-35 (P = .0001) and IL-10 (P = .006) was significantly elevated in comparison with healthy controls. | 29324262 | 2018 |
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0.100 | Biomarker | disease | BEFREE | Nasosorption (but not NPA) levels of interferon γ, interleukin 1β, CCL5/RANTES, and interleukin 10 (IL-10) were elevated in RSV+ bronchiolitis (all P < .05), furthermore CCL5 and IL-10 correlated with RSV load (P < .05). | 28368490 | 2017 |
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0.100 | Biomarker | disease | BEFREE | Conversely, murine studies indicate that the combined actions of regulatory factors such as CD4 regulatory T cells and IL-10 inhibit the inflammatory cytokine response and limit RSV-induced disease. | 24838148 | 2014 |
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0.100 | Biomarker | disease | BEFREE | SNPs in several genes were associated with increased chronic respiratory morbidity (interleukin 10 (IL10), nitric oxide synthase 2A (NOS2A), surfactant protein C (SFTPC), matrix metalloproteinase 16 (MMP16) and vitamin D receptor (VDR)) and reduced lung function at 1 year (MMP16, NOS2A, SFTPC and VDR) in infants who had had RSV LRTIs. | 24487983 | 2014 |
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0.100 | AlteredExpression | disease | BEFREE | We concluded that genetic variation in adaptive immunity genes and particularly in IL19/IL20 genes associates with the development of recurrent wheeze after RSV LRTI, suggesting a role for these IL10 family members in the etiology of airway disease during infancy. | 21814157 | 2011 |
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0.100 | Biomarker | disease | BEFREE | Clinical studies have documented that certain polymorphisms in the gene encoding the regulatory cytokine IL-10 are associated with the development of severe bronchiolitis in RSV infected infants. | 21829368 | 2011 |
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0.100 | AlteredExpression | disease | BEFREE | TLR4 signaling is required for peroxisome proliferator-activated receptor gamma expression, a DNA-binding protein that induces AA-M phi genes, whereas IFN-beta regulates IL-4, IL-13, IL-4R alpha, and IL-10 expression in response to RSV. | 20404812 | 2010 |
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0.100 | GeneticVariation | disease | BEFREE | Infants with bronchiolitis associated with a virus other than respiratory syncytial virus (N = 18), were more often IL-10 -1082 allele G non-carriers, that is, homozygous for allele A (AA) than controls (66.7% vs. 28.0%, P < 0.0001). | 18286551 | 2008 |
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0.100 | Biomarker | disease | BEFREE | The concentration of IL-10 (p=0.04) and TNF-alpha (p=0.006) in the RSV-positive group was significantly higher than in the hBoV-positive group, while there was no difference in other cytokines concentration between the two groups. | 18650126 | 2008 |
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0.100 | Biomarker | disease | BEFREE | We previously showed that airflow limitation during RSV LRTI as well as convalescent monocyte IL-10 production are associated with early wheezing. | 17313976 | 2007 |
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0.100 | Biomarker | disease | BEFREE | We investigated the role that IL-10 plays in RSV disease by studying the effects that variation in the IL10 gene has on the outcome of the disease. | 15838798 | 2005 |
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0.100 | GeneticVariation | disease | BEFREE | In children hospitalized at < or =6 months of age, a significant association between RSV bronchiolitis and the IL-10 -592C allele was found (OR, 1.61; 95% CI, 1.10-2.35). | 14722888 | 2004 |
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0.100 | AlteredExpression | disease | BEFREE | Analysis of total pulmonary cytokine mRNA isolated 1 and 4 days following infection with rRSV/mIL-2 revealed elevated levels of mRNA for IL-2, gamma interferon (IFN-gamma), IL-4, IL-5, IL-6, IL-10, IL-13, and IL-12 p40 compared to those for wt rRSV. | 10888656 | 2000 |