IL10, interleukin 10, 3586

N. diseases: 1679; N. variants: 21
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 AlteredExpression phenotype BEFREE Moreover, CPB2 positively correlates with IL10 mRNA expression, incidence of CD14<sup>+</sup> cells and lymphovascular invasion in IBC patients. 29459177 2019
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 Biomarker phenotype BEFREE IL‑10 secreted by cancer‑associated macrophages regulates proliferation and invasion in gastric cancer cells via c‑Met/STAT3 signaling. 31233202 2019
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 Biomarker phenotype BEFREE In this study the roles of IL-6/IL-10 in regulating vascular invasion and their prognostic significance in BC are investigated. 29256156 2018
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 AlteredExpression phenotype BEFREE HCC-conditioned TAMs pretreated with miR-98 regulated migration and invasion of HepG2 cells in vitro, and the effects were significantly reversed by IL-10. 29702181 2018
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 Biomarker phenotype BEFREE In contrast, IL-10 responses in both cell types were PI 3-kinase/Akt-dependent.<i>C. jejuni</i> strains showed diverse levels of invasion with high invasion dependent on MAP kinase signaling in both cell lines.<i>C. jejuni</i> induced diverse cytotoxic responses in both cell lines with <i>cdt</i>-positive isolates showing significantly higher toxicity. 29033908 2017
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 Biomarker phenotype BEFREE However, the anti-inflammatory cytokine IL-10 was produced by pyramidal neurons of CA2 and CA3 at 3 dpi when there is no destructive change or viral invasion in the hippocampus. 28493345 2017
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 Biomarker phenotype BEFREE Progressively, PLGA/anti-CTLA-4 had better suppressive activity to inhibited IL-10 and TGF-beta secreted by CD4+CD25+Treg cells which indicating that PLGA/anti-CTLA-4 suppressed cells proliferation and invasion through reduced IL-10 and TGF-beta production. 27989857 2017
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 Biomarker phenotype BEFREE Our results show that IL-10-stimulated macrophages are more efficient in promoting in vitro cancer cell invasion and migration. 26043921 2015
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 Biomarker phenotype BEFREE To verify which molecule could be responsible for IL-10-mediated soft agar growth and invasion capability, PCR array and mechanistic strategies were conducted. 23743567 2013
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 GeneticVariation phenotype BEFREE The patients with IL10 rs3021094 GG genotype also had a poorer overall survival in Kaplan-Meier analysis (log-rank P=0.007) and in multivariate Cox regression model (P=0.044) adjusting for age, gender, carcinoembryonic antigen levels, tumor differentiation, stage, lymphovascular invasion, and perineural invasion. 24015034 2013
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 AlteredExpression phenotype BEFREE IL11 expression in TAMs might play more important role than IL10 and IL18 expression in regulating the invasion of gastric cancer cells under hypoxia. 22595646 2012
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 AlteredExpression phenotype BEFREE A statistically significant increase in cell proliferation and invasion as well as TGF-β2 and IL-10 expression was observed in U87.MG.EGFRvIII cells as compared with U87.MG cells. 21511480 2011
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.100 AlteredExpression phenotype BEFREE Our results indicated that low expression haplotype of IL-10 in Bowen's disease may inhibit the escape of tumor cells from immune surveillance, resulting in suppression of tumor growth and tumor invasion to the dermis. 18173702 2008