|
IMMUNE SUPPRESSION
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Both TGF-β and IL-10 have immune suppression effects to downregulate secretion and release of inflammatory factors, such as TNF-α, that play roles in regulating osteoblast and osteoclast functions.
|
30050032 |
2018 |
|
IMMUNE SUPPRESSION
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Although IL-10-producing B cells represent a major subset of regulatory B cells (Bregs) able to suppress autoimmune and inflammatory responses, recent reports showed that B cell-mediated immune suppression may also occur independent of IL-10.
|
30327652 |
2018 |
|
IMMUNE SUPPRESSION
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Tregs are high in leprosy patients and responsible for immune suppression of the host by producing IL-10 and TGF-β cytokines.
|
28110210 |
2017 |
|
IMMUNE SUPPRESSION
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
IL-10 and TGF-β producing Tregs are high in leprosy patients and responsible for immune suppression and M. leprae specific T cells anergy.
|
28038394 |
2017 |
|
IMMUNE SUPPRESSION
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
A hallmark of subgroup A is a high expression of clinically unfavorable markers, including (i) high CD163 expression, a surface receptor characteristic of an anti-inflammatory activation state, (ii) increased PCOLCE2 expression, indicative of enhanced extracellular matrix organization, and (iii) elevated ascites levels of IL-6 and IL-10, linked to the aggressiveness of ovarian cancer and immune suppression.
|
28327095 |
2017 |
|
IMMUNE SUPPRESSION
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
New Insights into IL-10 Dependent and IL-10 Independent Mechanisms of Regulatory B Cell Immune Suppression.
|
27008462 |
2016 |
|
IMMUNE SUPPRESSION
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The combination of oral delivery of bioencapsulated FIX and intravenous replacement therapy induced a complex, interleukin-10 (IL-10)-dependent, antigen-specific systemic immune suppression of pathogenic antibody formation (immunoglobulin [Ig] 1/inhibitors, IgE) in hemophilia B mice.
|
25700434 |
2015 |
|
IMMUNE SUPPRESSION
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Herein, we describe a protocol for in vitro synthesis of small interfering RNA against IDO and other immunosuppressive factors such as interleukin-10 and programmed cell death-1 ligands in order to reverse immune suppression mediated by DCs.
|
25319657 |
2015 |
|
IMMUNE SUPPRESSION
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The stimulation of peripheral blood mononuclear cells with r-LdODC up-regulated IL-10 production but not IFN-γ production from CD4(+) T cells in active as well as cured visceral leishmaniasis cases, indicating a pivotal role for r-LdODC in causing strong immune suppression in a susceptible host.
|
25449949 |
2015 |
|
IMMUNE SUPPRESSION
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Once generated, B10 cells respond to both innate and adaptive immune signals, with a requirement for antigen-specific local interactions with T cells to induce IL-10 production and to provide optimal immune suppression in mouse models of autoimmune disease.
|
26254185 |
2015 |
|
IMMUNE SUPPRESSION
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Among the various immune evasion strategies exhibited by the parasite, Interleukin 10 (IL-10) productions and IL-10 mediated immune suppression has significant negative impact on the host immune system.
|
22496777 |
2012 |
|
IMMUNE SUPPRESSION
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Furthermore, IL-10 plays an important role in the immune suppression by IL-22.
|
21998459 |
2011 |
|
IMMUNE SUPPRESSION
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The data suggest that tumor cell-derived HMGB1 may suppress naturally acquired CD8 T cell-dependent antitumor immunity via enhancing Treg to produce IL-10, which is necessary for Treg-mediated immune suppression.
|
21642542 |
2011 |
|
IMMUNE SUPPRESSION
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
These data indicate that multiple cell types contribute to IL-10-mediated immune suppression in the presence of uncontrolled HIV viremia.
|
19365081 |
2009 |
|
IMMUNE SUPPRESSION
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Our findings reveal a novel mechanism of age-associated IL-10 mediated pulmonary immune suppression with the potential to alter downstream adaptive immunity.
|
17631521 |
2007 |
|
IMMUNE SUPPRESSION
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Tumor necrosis factor-alpha (TNF-alpha) is a multifunctional cytokine capable of activating T and dendritic cells (DCs) and counteracting IL-10-mediated DC inhibition and regulatory T-cell-mediated immune suppression.
|
17479109 |
2007 |