Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
The role of IDO, IL-10, and TGF-β in the HCV-associated chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma.
|
29611873 |
2019 |
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
We found that HMGB1 on TRAPs from human hepatocellular carcinoma cell line HepG2 played a significant role in IL-10-producing B cell induction.
|
31568811 |
2019 |
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
The experiments were performed in 5 groups (phosphate buffered saline/PBS, BMSCs, BMSC-IFN-γ, BMSC-IL-10 and BMSC-IFN-γ-IL-10) and the genetically engineered BMSCs were transplanted into HCC mice.
|
29332347 |
2019 |
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Furthermore, combinations of CTLA-4 -318 TC/TT and TNF -238 GG/GA; CTLA-4 -318 TC/TT and IL 10 -819 CC; CTLA-4 -318 CC and IL 10 -819 CT/TT in patients with HCC were statistically significant (P < .05).
|
31448426 |
2019 |
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Unlike liver patients without malignancy and healthy controls, the frequency of checkpoint inhibitor-positive Tregs inversely correlated to age of patients with HCC (PD-L1, p = 0.0080; CTLA-4, p = 0.0029) and corresponded to enhanced numbers of Tregs producing IL-10 and IL-35 (p < 0.05 each).
|
31724091 |
2019 |
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Hypoxia-inducible gene 2 promotes the immune escape of hepatocellular carcinoma from nature killer cells through the interleukin-10-STAT3 signaling pathway.
|
31142329 |
2019 |
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
The fusion protein had the bispecific ability to target both IL-10 and CD19 molecules in vitro.Intramuscularly (i.m.) injecting mice with pcCD19scFv-IL-10R plasmid inhibited hepatocellular carcinoma growth in vivo.
|
30404730 |
2018 |
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
TLR4 mRNA expression positively correlated with IL-6 and IL-10 mRNA expression in HCC tumors and the correlation was stronger in obese HCC patients.
|
30034633 |
2018 |
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Following treatment with Foxp3-shRNA, the average tumor volume, ratio of Tregs/CD4<sup>+</sup> T cells and level of IL-10, TGF-β and VEGF significantly decreased, however, the level of IFN-γ and IL-2 significantly increased compared with un-treated HCC mice (P<0.05).
|
29387180 |
2018 |
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
NKG2D, CD40, IL-2 and IL-10 are important modulators in the development and progression of HCC.
|
29568203 |
2018 |
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Our results showed that miR-98 was downregulated and IL-10 was upregulated in HCC tissues and HCC-conditioned TAMs.
|
29702181 |
2018 |
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Mechanistically, sunitinib treatment primes the antitumor immune response by significantly decreasing Treg frequency, reducing TGF-β and IL-10 production by Tregs, and also protecting TAS CD8<sup>+</sup> T cells from tumor-induced deletion in the setting of HCC.
|
29296523 |
2017 |
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
The tumor microenvironment was improved in DEX<sub>AFP</sub>-treated HCC mice, demonstrated by significantly more γ-interferon (IFN-γ)-expressing CD8<sup>+</sup> T lymphocytes, elevated levels of IFN-γ and interleukin-2, and fewer CD25<sup>+</sup>Foxp3<sup>+</sup> regulatory T (Treg) cells and decreased levels of interleukin-10 and transforming growth factor-β in tumor sites.
|
28549917 |
2017 |
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
IL-6 and IL-10 were significantly increased in both the HCC and GBC groups, IL-2, IL-6, IL-10, and TNF-<i>α</i> in the cholangiocellular carcinoma group, and IL-2, IL-6, IL-8, and TNF-<i>α</i> in the pancreatic cancer group.
|
29410961 |
2017 |
Liver carcinoma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Genetic variants in IL-6 and IL-10 genes and susceptibility to hepatocellular carcinoma in HCV infected patients.
|
28340949 |
2017 |
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
These cells also express programmed death ligand 1 (PD-L1) and interleukin-10, and directly suppress liver cytotoxic CD8<sup>+</sup> T lymphocytes, which prevent emergence of hepatocellular carcinoma and express a limited repertoire of T-cell receptors against tumour-associated antigens.
|
29144460 |
2017 |
Liver carcinoma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis was designed to examine the association of three promoter polymorphisms (-592C > A, -819C > T and -1082G > A) in IL-10 gene with the risk for colorectal cancer and hepatocellular carcinoma.
|
27489033 |
2016 |
Liver carcinoma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Additionally, the IL-10 -819 (-592) TT (AA) genotype was significantly associated with multiple nodules and HCC severity according to BCLC staging (P = 0.044 and P = 0.025, respectively).
|
26890368 |
2016 |
Liver carcinoma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
We conclude that the IL-10 -592G/A polymorphism does play a role in susceptibility to HBV-related HCC under codominant, dominant, and recessive models.
|
27050962 |
2016 |
Liver carcinoma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
No significant difference in the frequency of IL-10 SNP at position -1082 or IFN-γ at position +874T/A was found between chronic HCV genotype 4 and with progression of disease severity in liver cirrhosis or HCC.
|
26163635 |
2015 |
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
In this study, we investigated the influence of IL-21 on HBV replication based on human hepatoma Huh7.93 cells co-cultured with human peripheral blood mononuclear cells (PBMCs) and the possible correlation among IL-21, interferon-γ, tumour necrosis factor-α and IL-10.
|
25774942 |
2015 |
Liver carcinoma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The present study was designed to evaluate the impact of IL-10 (-819/-592) genotypes, haplotypes, mRNA and the protein levels with risk for hepatitis B virus (HBV) related hepatocellular carcinoma (HCC) development in India.
|
25027084 |
2014 |
Liver carcinoma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
In addition, combination analysis with the Th1 cytokine (IFN-γ, IL-2, IL-12B, TGF-β1) or Th2 cytokine (IL-6, IL-10) genetic polymorphisms by the Kaplan-Meier method and Cox multivariate analysis did not reveal any significant association between OS and RFS of resected HCC patients.
|
24768182 |
2014 |
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
We have measured secretion of hepcidin by primary macrophages and the hepatoma cell line HepG2 stimulated with IL-10, IL-6 and Plasmodium falciparum-infected erythrocytes.
|
24520384 |
2014 |
Liver carcinoma
|
0.300 |
Therapeutic
|
disease |
RGD |
Radiofrequency ablation suppresses distant tumour growth in a novel rat model of multifocal hepatocellular carcinoma.
|
23822114 |
2014 |