|
Alzheimer's Disease
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
These results suggest that IL-4 and IL-13 that were endogenously expressed from reactive microglia may play a critical role on neuronal death by regulating oxidative stress during the neurodegenerative diseases, such as Alzheimer's disease and dementia.
|
31010119 |
2019 |
|
Alzheimer's Disease
|
0.080 |
Biomarker
|
disease |
BEFREE |
Through screening, we selected miR-106b, miR-146b, miR-181a, miR-200a, miR-34a, miR-124b, miR-153, miR-155, Aβ<sub>1-42</sub> monomer (mAβ), Aβ<sub>1-42</sub> oligomer (oAβ), UCHL1, NLRP3, Tau, STAT3, SORL1, Clusterin, APOE3, APOE4, Nogo-A, IL-13, and Visfatin to serve as AD- and inflammation-related markers.
|
31515517 |
2019 |
|
Alzheimer's Disease
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
Plasma and cerebrospinal fluid (CSF) from 198 patients with Alzheimer's disease participating in the Preserving Cognition, Quality of Life, Physical Health and Functional Ability in Alzheimer's Disease: The Effect of Physical Exercise (ADEX) study were analyzed for concentrations of 8‑isoprostane, soluble trigger receptor expressed on myeloid cells 2 (sTREM2), and the MSD v-plex proinflammation panel 1 human containing interferon gamma (IFNγ), Interleukin-10 (IL10), IL12p70, IL13, IL1β, IL2, IL4, IL6, IL8, and tumor necrosis factor alpha (TNFα), before and after a 16-week intervention with physical exercise, and we studied whether changes were modulated by the patients' APOE genotype.
|
30980923 |
2019 |
|
Alzheimer's Disease
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
Both classical IL-10 and non-classical IL-13 anti-inflammatory cytokines were significantly downregulated (P < 0.001) in AD patients when compared with non-AD controls.
|
27215446 |
2017 |
|
Alzheimer's Disease
|
0.080 |
Biomarker
|
disease |
BEFREE |
This unique mechanism of IL-4/IL-13-induced clearance of Aβ may provide an additional strategy to prevent and/or cure Alzheimer's disease at early stage.
|
22342341 |
2012 |
|
Alzheimer's Disease
|
0.080 |
Biomarker
|
disease |
BEFREE |
We sought to characterize the P600 and N400 word repetition effects in patients with fragile X-associated tremor/ataxia syndrome, using an event-related potential word repetition paradigm with demonstrated sensitivity to very early Alzheimer's disease.
|
20410144 |
2010 |
|
Alzheimer's Disease
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
In this study, it is shown that Bcl-3 is inducible by the Th2 cytokines IL-4 and IL-13 and is overexpressed in lesional skin of atopic dermatitis (AD) patients.
|
19282837 |
2009 |
|
Alzheimer's Disease
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, we demonstrate the down-regulatory effect of IL-4, IL-10, and IL-13 - which are over-expressed in the skin of AD patients - on HBD-3 expression in keratinocytes.
|
17015038 |
2006 |