|
Ulcerative Colitis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Ulcerative colitis (UC) is a Th2 inflammatory bowel disease characterized by increased IL-5 and IL-13 expression, eosinophilic/neutrophilic infiltration, decreased mucus production, impaired epithelial barrier, and bacterial dysbiosis of the colon.
|
31643033 |
2020 |
|
Ulcerative Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Recent studies suggested that IL-13, IL5 and IL-4 are involved in the occurrence and the development of UC.
|
30638678 |
2019 |
|
Ulcerative Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Failure of the anti-IL-13 monoclonal antibodies tralokinumab and anrukinzumab in UC patients in clinical trials support the absence of a role for IL-13 in UC.
|
30844559 |
2019 |
|
Ulcerative Colitis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
A rat UC model was induced with trinitro-benzene-sulfonic acid (TNBS), concentrations of the cytokines IL-1α, IL-6, IL-8, IL-1β, and TNF-α were significantly up-regulated and the concentrations of IL-4, IL-10, and IL-13 were significantly down-regulated compared with the control group (P < 0.05).
|
31102937 |
2019 |
|
Ulcerative Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Previous studies have revealed that IL-13 is implicated in the pathogenesis of autoimmune diseases, such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), systemic sclerosis (SSc), ulcerative colitis (UC), type 1 diabetes (T1D), sjogren's syndrome (SS), etc.
|
30581068 |
2019 |
|
Ulcerative Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
MicroRNA-31 and MicroRNA-155 Are Overexpressed in Ulcerative Colitis and Regulate IL-13 Signaling by Targeting Interleukin 13 Receptor α-1.
|
29438285 |
2018 |
|
Ulcerative Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The potential role of IL-13 signaling independently of IL-4Rα in mediating ulcerative colitis is highlighted as an important consideration when targeting the signaling mechanisms of IL-13 for therapeutic approaches.
|
30460209 |
2018 |
|
Ulcerative Colitis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
AS002 and rosiglitazone increased ADIPOPHILIN mRNA expression (3-fold) and decreased TNF-α, IL-1β, and IL-13 levels in human UC biopsies.
|
29529198 |
2018 |
|
Ulcerative Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Expression of cyp27b1 in peripheral CD14<sup>+</sup> cells was correlated with miR-19a and serum IL-13 in UC patients.
|
27381199 |
2017 |
|
Ulcerative Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Elevated levels of IL-4 (2.91-fold) and IL-13 (4.05-fold) mRNA were detected in the inflamed colon mucosa of patients with ulcerative colitis (UC), IFN-γ mRNA was upregulated (3.23-fold) in the inflamed colon mucosa of patients with Crohn's disease (CD), whereas upregulation of IL-17A and TL1A mRNA was present in the inflamed colon mucosa of patients with both CD and UC (IL-17A: 4.48-fold and 2.74-fold, TL1A: 3.19-fold and 3.22-fold, respectively) vs. control subjects.
|
26072972 |
2015 |
|
Ulcerative Colitis
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
IL-13 induces phosphorylation of STAT6, and we previously demonstrated increased epithelial p-STAT6 in children with UC.
|
23303670 |
2013 |
|
Ulcerative Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
STAT6 activation in ulcerative colitis: a new target for prevention of IL-13-induced colon epithelial cell dysfunction.
|
21308881 |
2011 |
|
Ulcerative Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Ulcerative colitis is associated with an atypical Th2 response mediated by a distinct subset of NK T cells that produce IL-13 and are cytotoxic for epithelial cells.
|
16048556 |
2005 |
|
Ulcerative Colitis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
IL-10 and IL-4 but not IL-13 suppressed the NO production and iNOS expression by inflamed tissue and cytokine-stimulated noninflamed tissue from patients with ulcerative colitis, whereas the three cytokines suppressed NO production in cytokine-stimulated biopsies from controls.
|
16298681 |
2005 |
|
Ulcerative Colitis
|
0.100 |
Biomarker
|
disease |
LHGDN |
These studies show that UC is associated with an atypical Th2 response mediated by nonclassical NKT cells producing IL-13 and having cytotoxic potential for epithelial cells.
|
15146247 |
2004 |
|
Ulcerative Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Through the study of patients and mouse models, it has emerged that Crohn's disease is driven by the production of interleukin-12 (IL-12) and interferon-gamma (IFN-gamma), whereas ulcerative colitis is probably driven by the production of IL-13.
|
12876555 |
2003 |
|
Ulcerative Colitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Positive expressions of IL-4 (66.7% vs 20.6%, p < 0.01) and IL-13 (63.0% vs 29.4%, p < 0.01) were higher in active UC than in inactive UC.
|
10484006 |
1999 |
|
Ulcerative Colitis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The data suggest that the epithelium is the major source of iNOS activity in ulcerative colitis and that IL-13 and IL-4 may act as intrinsic regulators of NO generation in intestinal inflammation.
|
9771406 |
1998 |