Hodgkin Disease
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
In another cohort, serum levels of MIP-1α, MIP-1β and IL-13 were increased in HL patients (n = 53) and highest in EBV-positive HL patients as compared with healthy controls (n = 40).
|
27632954 |
2017 |
Hodgkin Disease
|
0.200 |
GeneticVariation
|
disease |
GWASDB |
A meta-analysis of Hodgkin lymphoma reveals 19p13.3 TCF3 as a novel susceptibility locus.
|
24920014 |
2014 |
Hodgkin Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
HD patients who did not develop anti-HBs despite HBV infection also did not differ in genotype frequencies of IL4R (TT 67.8%, CT 26.8%, CC 5.4%) and IL13 (CC 60.7%, CT 33.9%, TT 5.4%) from HD patients who developed an anti-HBs response (IL4R TT 65.4%, CT 30.8%, CC 3.8%; IL13 CC 60.5%, CT 34.6%, TT 4.9%).
|
23462527 |
2013 |
Hodgkin Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
No associations were observed between the other IL-10 gene variations, IL-13(-1069CT), IL-13(Q144R), IL-4R(I75V), IL-4R(Q576R) and the clinical outcome of patients with HL.
|
23299779 |
2013 |
Hodgkin Disease
|
0.200 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study of classical Hodgkin lymphoma and Epstein-Barr virus status-defined subgroups.
|
22286212 |
2012 |
Hodgkin Disease
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study of classical Hodgkin lymphoma and Epstein-Barr virus status-defined subgroups.
|
22286212 |
2012 |
Hodgkin Disease
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Because Hodgkin/Reed-Sternberg cells are known to secrete IL-13, to have constitutively activated STAT6, and to be closely surrounded by CD4(+) T cells, these mechanisms may be involved in the expression of LMP-1 in EBV-positive chronic HLs.
|
20876453 |
2011 |
Hodgkin Disease
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
A correlation between GATA3 and IL-13 expression was confirmed for HRS cells in HL tissues.
|
20660789 |
2010 |
Hodgkin Disease
|
0.200 |
Biomarker
|
disease |
BEFREE |
Thus, Zta-induced IL-13 production facilitates B-cell proliferation and may contribute to the pathogenesis of EBV-associated lymphoproliferative disorders, such as posttransplantation lymphoproliferative disease (PTLD) and Hodgkin lymphoma.
|
19417211 |
2009 |
Hodgkin Disease
|
0.200 |
Biomarker
|
disease |
BEFREE |
IL-13 exerts proliferative and antiapoptotic functions and is linked to leukemogenesis, since it stimulates Hodgkin lymphoma cells by an autocrine mechanism.
|
15163701 |
2004 |
Hodgkin Disease
|
0.200 |
Biomarker
|
disease |
LHGDN |
The role of interleukin 13 in classical Hodgkin lymphoma.
|
12152987 |
2002 |
Hodgkin Disease
|
0.200 |
Biomarker
|
disease |
BEFREE |
These results suggest that IL-13 signaling is largely responsible for the constitutive STAT6 activation observed in HRS cells and further implicate IL-13 as an important growth factor in classical HL.
|
11781246 |
2002 |
Hodgkin Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Although LE and IL-13 transcripts were detected in several non-Hodgkin's lymphomas, immunohistochemical analysis of lymphoma tissues also showed that LE was strongly expressed in infiltrating leukocytes.
|
11590195 |
2001 |
Hodgkin Disease
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
The expression of IL-13 and IL-13 receptor (IL-13R) was determined by immunostaining and reverse transcriptase-polymerase chain reaction in 39 cases of HD, including 17 cases with nodular sclerosis (NS) type, 19 cases with mixed cellularity (MC), and three cases with lymphocyte predominance (LP) type.
|
11318902 |
2001 |
Hodgkin Disease
|
0.200 |
Biomarker
|
disease |
BEFREE |
These data indicate that expression of IL-13 and IL-13Ralpha1 is a common feature of HRS cells in HL, consistent with the hypothesis that IL-13 may play a role in autocrine growth in classical HL.
|
11133768 |
2001 |
Hodgkin Disease
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Therefore, additional studies should be performed to determine the expression of IL-13 and IL-13R in primary clinical samples of Hodgkin's lymphoma and both agents should be further tested in vitro and in vivo as possible therapeutic agents for HL.
|
11585386 |
2001 |
Hodgkin Disease
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
In situ hybridization of lymph node tissue from HD patients showed that elevated levels of IL-13 were specifically expressed by Hodgkin/Reed-Sternberg (H/RS) tumor cells.
|
10377189 |
1999 |