Nasal Polyps
|
0.100 |
Biomarker
|
disease |
BEFREE |
Mast cell expresses IL-5, IL-13, and periostin, and it plays a role in the pathogenesis of nasal polyps through orchestrating eosinophil infiltration.
|
31567293 |
2020 |
Nasal Polyps
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Expression of TNF-α, IL-2, IL-4, IL-5, and IL-13 mRNA in the NPs treated by steroid, AZA, and 6-MP were significantly lower than those of the control (p < 0.001 for all).
|
30748107 |
2019 |
Nasal Polyps
|
0.100 |
Biomarker
|
disease |
BEFREE |
At this time, while there are no FDA-approved biologics for use in NP, research has highlighted the contributions of IL-4, IL-5, IL-13, and IgE as disease mediators in the pathogenesis of NP.
|
31073812 |
2019 |
Nasal Polyps
|
0.100 |
Biomarker
|
disease |
BEFREE |
Dupilumab, a fully human monoclonal antibody that binds IL-4Rα and inhibits signaling of both IL-4 and IL-13, has shown efficacy across multiple diseases with underlying type 2 signatures and is approved for treatment of asthma, atopic dermatitis and chronic sinusitis with nasal polyposis.
|
31838750 |
2019 |
Nasal Polyps
|
0.100 |
Biomarker
|
disease |
BEFREE |
SIT scores were inversely correlated with levels of IL-2 (P = .006), IL-5 (P < .0001), IL-6 (P = .0009), IL-10 (P < .0001), and IL-13 (P < .0001), with significance largely driven by CRSwNP patients.
|
29417576 |
2018 |
Nasal Polyps
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
After administration of rmIL-33, ECP, IL-5 and IL-13 were all increased in tissues from CRSsNP and CRSwNP patients, however, there were no significant differences between them.
|
30357493 |
2018 |
Nasal Polyps
|
0.100 |
Biomarker
|
disease |
BEFREE |
We quantified SCCs and ILC2s using multicolor flow cytometry in nasal polyps and non-inflamed turbinate mucosa from seven patients and investigated the role of IL-13 and dexamethasone on SCC frequency using tissue explants of nasal polyps and turbinate mucosa.
|
29742315 |
2018 |
Nasal Polyps
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The protein and mRNA expression levels of IL-13 and its receptors in nasal biopsies of patients with nasal polyps (NP) and healthy controls were evaluated.
|
29405354 |
2018 |
Nasal Polyps
|
0.100 |
Biomarker
|
disease |
BEFREE |
Logistic regression analysis demonstrated a significant association of IL-13 with NP.
|
29561922 |
2018 |
Nasal Polyps
|
0.100 |
Biomarker
|
disease |
BEFREE |
The objective of this study was to determine differential expression of POSTN, IL-4, and IL-13 genes in the mucosa and polyps of 63 patients with CRSwNP and 23 chronic rhinosinusitis (CRS) without nasal polyps (CRSsNP) when compared with patients with nasal septum deviation (n=18) who were used as controls.
|
25674935 |
2015 |
Nasal Polyps
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Expression of SPLUNC1 protein in nasal polyp epithelial cells in air-liquid interface culture treated with IL-13.
|
20109312 |
2010 |