|
Allergic asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In the current report, we examine whether combined blockade of IL-13 and IL-17A, at individually sub-therapeutic levels, can limit the development of allergic asthma while sparing expression of IL-17A-associated anti-microbial effectors.
|
30353972 |
2019 |
|
Allergic asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
IL-4 and IL-13 levels were significantly higher at baseline in the AA group compared with HS and, after allergen exposure, were significantly increased in the AA group, with no effect on HS.
|
31486098 |
2019 |
|
Allergic asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The impact of the recombinantly produced IL-4 and IL-13 antagonist IL-4 mutein (IL-4M) on allergic sensitization and AIT outcome in experimental allergic asthma were analyzed in a murine model.
|
30829405 |
2019 |
|
Allergic asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, we found that intranasal administration of miR‑410 effectively inhibited airway inflammation in OVA‑induced asthmatic mice by targeting IL‑4 and IL‑13 at the post‑transcriptional level. miR‑410 is thus a promising treatment for allergic asthma.
|
30535486 |
2019 |
|
Allergic asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Inhaled CDP7766 potently inhibited the function of IL-13 generated during the airway response to inhaled allergen in cynomolgus macaques, demonstrating the potential of inhaled anti-IL-13 therapeutics for the treatment of allergic asthma.
|
29883204 |
2018 |
|
Allergic asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our findings unveil the "protease-FCP-TLR4-mast cell-IL-13" axis as a molecular mechanism for generation of T<sub>H</sub>2-favorable PD-L2<sup>+</sup> DCs in allergic asthma and suggest that targeting the PD-L2<sup>+</sup> DC pathway might be effective in suppressing allergic T-cell responses in the airway.
|
29038008 |
2018 |
|
Allergic asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The mean IL-13 serum cytokine levels were found to be significantly high in atopic (38.48 ± 36.54) and non-atopic (36.05 ± 34.54) asthma patients whereas total serum IgE levels were significantly high at p < 0.0001 in atopic and low in non-atopic asthma patients at p < 0.003 compared to HC.
|
28083766 |
2017 |
|
Allergic asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
A Comprehensive Evaluation of Nasal and Bronchial Cytokines and Chemokines Following Experimental Rhinovirus Infection in Allergic Asthma: Increased Interferons (IFN-γ and IFN-λ) and Type 2 Inflammation (IL-5 and IL-13).
|
28373098 |
2017 |
|
Allergic asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
IL-6 has been shown to play an important role in chronic obstructive pulmonary disease (COPD), while IL-13 is described as one of the key mediators of allergic asthma.
|
28791839 |
2017 |
|
Allergic asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Allergic asthma is a T helper 2 cell (Th2)-mediated disease, in which Th2 cytokines interleukin (IL)-4, IL-5, and IL-13 are closely associated with the symptoms.
|
26965110 |
2016 |
|
Allergic asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We hypothesized that IL-13 modulates elastin expression in airway fibroblasts from subjects with allergic asthma.
|
26074138 |
2016 |
|
Allergic asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In contrast, deficiency of IL-13 prevented allergic asthma, irrespective of the presence or absence of IL-4Rα-responsive CD4(+) T cells.
|
26688514 |
2016 |
|
Allergic asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Moreover, maternal stress can alter fetal cytokine balance, favoring TH2 (allergic) immune responses characteristic of atopic asthma: interleukin 6 (IL-6), which has been associated with premature labor, can promote TH2 responses by stimulating production of IL-4 and IL-13.
|
26676148 |
2015 |
|
Allergic asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results demonstrate an anti-lymphangiogenic function of TH2 cells and their cytokines, suggesting a potential usefulness of IL-4 and/or IL-13 antagonist as therapeutic agents for allergic asthma through expanding LV mediated-enhanced antigen clearance from the inflammatory sites.
|
25648335 |
2015 |
|
Allergic asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
IL-13 receptor α2 contributes to development of experimental allergic asthma.
|
23763980 |
2013 |
|
Allergic asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
IL-13 gene polymorphisms and their association with atopic asthma and rhinitis in Pakistani patients.
|
23996716 |
2013 |
|
Allergic asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The IL-13R A(1) +1398 A/G polymorphism does not contribute to asthma or allergic rhinitis susceptibility, yet serum IL-13 can be used as a marker in atopic diseases and to differentiate between atopic and non-atopic asthma.
|
21425907 |
2011 |
|
Allergic asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
IL-13, a cytokine secreted by T(H)2 lymphocytes and other cells, critically modulates allergic inflammation and tissue remodeling in allergic asthma.
|
21616524 |
2011 |
|
Allergic asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Virus-induced wheezing has frequently been associated with IL-8 polymorphisms, whereas atopic asthma and atopy have frequently been associated with Th2 cytokine gene (CD14 and IL-13) polymorphisms on chromosome 5.
|
20126925 |
2009 |
|
Allergic asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
An acidic mammalian chitinase (AMCase) is produced in human epithelial cells of lower airways through a TH2-specific, interleukin-13-dependent pathway and appears to be associated with allergic asthma.
|
18216571 |
2008 |
|
Allergic asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
IL-13 promotes acute allergic asthma and is discussed to play a role in late asthmatic features such as fibrotic processes and airway remodelling.
|
18266877 |
2008 |
|
Allergic asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Expression of IL-13 gene in 70% of patients with allergic asthma was higher than controls (P=0.01).
|
17563406 |
2007 |
|
Allergic asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Association between the polymorphisms of IL-4 gene promoter (-590C>T), IL-13 coding region (R130Q) and IL-16 gene promoter (-295T>C) and allergic asthma.
|
17303923 |
2007 |
|
Allergic asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The role of Th2 cells (producing interleukin (IL-)4, IL-5 and IL-13) in allergic asthma is well-defined.
|
17083726 |
2006 |
|
Allergic asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The gene-gene interaction between risk alleles of each IL-13 promoter polymorphism and IL-13Ralpha1 polymorphism was associated with higher total IgE in children with atopic asthma (P=0.002, 0.010).
|
17006604 |
2006 |