IL13, interleukin 13, 3596

N. diseases: 587; N. variants: 9
Disease: Childhood asthma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0264408
Disease: Childhood asthma
Childhood asthma 		0.200 GeneticVariation disease BEFREE The gene polymorphisms of Arg130Gln in IL-13 and -590C/T in IL-4 gene promoter region were analyzed using the polymerase chain reaction (PCR) and direct gene sequencing; the asthma-related indexes were detected using the enzyme-linked immunosorbent assay, and the relevant indexes were analyzed; moreover, whether there was a synergistic effect between Arg130Gln in IL-13 and -590C/T in IL-4 gene promoter region in the pathogenesis of asthma in children was analyzed. 30680016 2019
CUI: C0264408
Disease: Childhood asthma
Childhood asthma 		0.200 GeneticVariation disease BEFREE However, IFN-γ/IL-13 and IFN-γ/IL-4 ratios during pregnancy were associated with a decreased risk of childhood asthma (n = 381; odds ratio [OR], 0.33; 95% confidence interval [CI], 0.17-0.66; P = 0.002; and n = 368; OR, 0.36; 95% CI, 0.18-0.71; P = 0.003, respectively). 29863910 2018
CUI: C0264408
Disease: Childhood asthma
Childhood asthma 		0.200 Biomarker disease BEFREE Moreover, neonatal mice were protected from AHR when inhaled <i>Acinetobacter lwoffii</i> (an environmental bacterial isolate found in cattle farms, which is known to protect from childhood asthma) was administered concurrent with HDM.<i>A. lwoffii</i> blocked the expansion of pulmonary IL-13<sup>+</sup>CD4<sup>+</sup> T cells, whereas IL-13<sup>+</sup> ILCs and IL-33 remained elevated.Administration of <i>A. lwoffii</i> mirrored the findings from the CD4<sup>cre</sup>IL-13 KO mice, providing a translational approach for disease protection in early life. 30194239 2018
CUI: C0264408
Disease: Childhood asthma
Childhood asthma 		0.200 GeneticVariation disease GWASCAT Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks. 29273806 2018
CUI: C0264408
Disease: Childhood asthma
Childhood asthma 		0.200 GeneticVariation disease BEFREE The aim of study was to investigate the combined effect of toll-like receptor 4 (TLR4), cluster of differentiation 14 (CD14), and interleukin-13 (IL-13) polymorphisms and bronchiolitis in the development of childhood asthma. 24376096 2015
CUI: C0264408
Disease: Childhood asthma
Childhood asthma 		0.200 GeneticVariation disease BEFREE IL-13 A2044G and RANTES G-28C are significantly associated with childhood asthma. 24053708 2013
CUI: C0264408
Disease: Childhood asthma
Childhood asthma 		0.200 GeneticVariation disease BEFREE However, few studies have explored the interactive effects between IL-13 haplotypes and environmental exposures on childhood asthma. 23382814 2013
CUI: C0264408
Disease: Childhood asthma
Childhood asthma 		0.200 GeneticVariation disease BEFREE The 6 loci (IL-13 C-1112T, IL-13 C1923T, IL-4 C-590T, IL-4RA 175V, FcER1B E237G and 12-ADR Q27E) make little contribution to the development of asthma in children of Chinese Han nationality. 19862939 2009
CUI: C0264408
Disease: Childhood asthma
Childhood asthma 		0.200 GeneticVariation disease BEFREE Genes located on chromosome 5q (ADRB2, IL13 and IL4) and the recently identified ORMDL3, on chromosome 17, seem to be determinants of childhood asthma. 18690379 2008
CUI: C0264408
Disease: Childhood asthma
Childhood asthma 		0.200 GeneticVariation disease BEFREE These data indicate that only the combined analyses of genetic alterations in the IL-4/IL-13 pathway reveal its actual significance to the development of atopy and childhood asthma. 16461126 2006
CUI: C0264408
Disease: Childhood asthma
Childhood asthma 		0.200 GeneticVariation disease BEFREE Univariate and multivariate family-based association analysis of the IL-13 ARG130GLN polymorphism in the Childhood Asthma Management Program. 12432502 2002