|
Rhinovirus infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
Tollip KO (vs. wild-type) mice developed exaggerated airway neutrophilic responses to RV in the context of IL-13 and IL-33 treatment.
|
30928973 |
2020 |
|
Rhinovirus infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
These observations suggested that the former ILC/DC profiles could be a predictor of a balanced cellular and humoral immune outcome.In addition, following i.n. delivery Rhinovirus (RV) and Adenovius type 5 (Ad5) vectors that induced elevated ILC2-derived IL-13, NKp46<sup>+</sup> ILC1/ILC3-derived-IFN-γ and no IL-17A, predominantly recruited CD11b<sup>-</sup> B220<sup>+</sup> plasmacytoid DCs (pDC).
|
30733092 |
2019 |
|
Rhinovirus infection
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Infants with rhinovirus had higher levels of NFκB-induced type-2 cytokines (IL-10 and IL-13; FDR<0.01).ConclusionIn infants with bronchiolitis, rhinovirus and RSV infections had different nasal airway microRNA profiles associated with NFκB signaling.
|
29244796 |
2018 |
|
Rhinovirus infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
The increase of Th2-related cytokines, especially IL-5 and IL-13, is a relevant biomarker for RV infection in asthmatic children with severe exacerbation.
|
30210646 |
2018 |
|
Rhinovirus infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
Interleukin-13 associates with life-threatening rhinovirus infections in infants and young children.
|
29665312 |
2018 |
|
Rhinovirus infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
TSLP was synergistically induced in epithelial cells by IL-13 and human rhinovirus.
|
28433687 |
2018 |
|
Rhinovirus infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
We have shown that RV infection of 6-day-old BALB/c mice, but not mature mice, induces an asthmalike phenotype that is associated with an increase in the population of type 2 innate lymphoid cells (ILC2s) and dependent on IL-13 and IL-25.
|
28360114 |
2017 |
|
Rhinovirus infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
Calu-3 cells, a well-differentiated human AEC line, were cultured with or without the T-helper type 2 cytokines interleukin (IL)-4 and IL-13, then stimulated with a toll-like receptor (TLR) 3 agonist (poly I:C, dsRNA) or a TLR7 agonist (imiquimod), or infected with RV 16.
|
28115681 |
2017 |
|
Rhinovirus infection
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We therefore examined the effects of intranasal IFN-γ administration on RV-induced ILC2 expansion and IL-13 expression in 6-day-old BALB/c and IL-13 reporter mice.
|
27679954 |
2017 |
|
Rhinovirus infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
Rhinovirus (RV) infection of 6-d-old mice, but not mature mice, causes mucous metaplasia and airway hyperresponsiveness that are associated with the expansion of lung type 2 innate lymphoid cells (ILC2s) and are dependent on IL-13 and the innate cytokine IL-25.
|
28701507 |
2017 |
|
Rhinovirus infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
A Comprehensive Evaluation of Nasal and Bronchial Cytokines and Chemokines Following Experimental Rhinovirus Infection in Allergic Asthma: Increased Interferons (IFN-γ and IFN-λ) and Type 2 Inflammation (IL-5 and IL-13).
|
28373098 |
2017 |
|
Rhinovirus infection
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Interestingly, human rhinovirus had a potentiating effect on IL-13-induced pendrin expression.
|
26143180 |
2015 |
|
Rhinovirus infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition, the population of IL-13-secreting type 2 innate lymphoid cells (ILC2s) was expanded with rhinovirus infection in neonatal but not mature mice.
|
24910174 |
2014 |