AQP3, aquaporin 3 (Gill blood group), 360

N. diseases: 124; N. variants: 1
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.330 AlteredExpression disease BEFREE Assessing the Expression of Aquaporin 3 Antigen-Recognition Sites in Oral Squamous Cell Carcinoma. 31373900 2019
CUI: C0037286
Disease: Skin Neoplasms
Skin Neoplasms
0.330 AlteredExpression group BEFREE To our knowledge, this work represents the first demonstration of AQP1/AQP3 expression in human melanocytic skin tumors. 31305898 2019
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.330 AlteredExpression disease BEFREE Taken together, the findings of the present study suggested that increased levels of AQP3 and PLD2 were correlated with tumor progression and development in SCC. 28656282 2017
CUI: C0037286
Disease: Skin Neoplasms
Skin Neoplasms
0.330 Biomarker group BEFREE AQP3 knockout mice were resistant to skin tumor formation and overexpression correlated with metastasis and poor prognosis in patients with breast or gastric cancer. 28991174 2017
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.330 Biomarker disease BEFREE Combination of AQP3-siRNA with cisplatin, a major anti-cancer drug, strongly inhibited the growth of SCC. 21401805 2011
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.330 Biomarker disease CTD_human Combination of AQP3-siRNA with cisplatin, a major anti-cancer drug, strongly inhibited the growth of SCC. 21401805 2011
CUI: C0037286
Disease: Skin Neoplasms
Skin Neoplasms
0.330 Biomarker group CTD_human Critical role of aquaporin 3 on growth of human esophageal and oral squamous cell carcinoma. 21401805 2011
CUI: C0037286
Disease: Skin Neoplasms
Skin Neoplasms
0.330 Biomarker group BEFREE We found that AQP3-null mice were remarkably resistant to the development of skin tumors following exposure to a tumor initiator and phorbol ester promoter. 17967887 2008
CUI: C0007114
Disease: Malignant neoplasm of skin
Malignant neoplasm of skin
0.320 AlteredExpression disease BEFREE Study of aquaporin 1 (AQP1) and aquaporin 3 (AQP3) expression to understand its potential role in the pathophysiology of skin cancer. 31305898 2019
CUI: C0007114
Disease: Malignant neoplasm of skin
Malignant neoplasm of skin
0.320 Biomarker disease BEFREE Dysregulation of AQP3 and Notch receptors has been reported in several skin diseases, including skin cancer. 24260356 2013
CUI: C0007114
Disease: Malignant neoplasm of skin
Malignant neoplasm of skin
0.320 Biomarker disease CTD_human Critical role of aquaporin 3 on growth of human esophageal and oral squamous cell carcinoma. 21401805 2011
CUI: C0153349
Disease: Malignant neoplasm of tongue
Malignant neoplasm of tongue
0.310 Biomarker disease BEFREE We have previously reported the expression on tumor cells and the important role of AQP3 on cell growth in tongue cancer. 22576684 2012
CUI: C0024232
Disease: Lymphatic Metastasis
Lymphatic Metastasis
0.310 Biomarker disease CTD_human Critical role of aquaporin 3 on growth of human esophageal and oral squamous cell carcinoma. 21401805 2011
CUI: C0153349
Disease: Malignant neoplasm of tongue
Malignant neoplasm of tongue
0.310 Biomarker disease CTD_human Critical role of aquaporin 3 on growth of human esophageal and oral squamous cell carcinoma. 21401805 2011
CUI: C0024232
Disease: Lymphatic Metastasis
Lymphatic Metastasis
0.310 GeneticVariation disease BEFREE On the other hand, seven studies analyzed various types of metastatic tissues (rarely visceral-, mostly cutaneous or lymphatic metastases) to define the metastasis-signatures, again with minimal overlap (AQP3, LGALS7 and SFN). 20177751 2010
Malignant neoplasm of urinary bladder
0.300 Biomarker disease CTD_human A case-control study of polymorphisms in xenobiotic and arsenic metabolism genes and arsenic-related bladder cancer in New Hampshire. 22306368 2012
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm
0.300 Biomarker disease CTD_human A case-control study of polymorphisms in xenobiotic and arsenic metabolism genes and arsenic-related bladder cancer in New Hampshire. 22306368 2012
CUI: C0014859
Disease: Esophageal Neoplasms
Esophageal Neoplasms
0.300 Biomarker group CTD_human Critical role of aquaporin 3 on growth of human esophageal and oral squamous cell carcinoma. 21401805 2011
CUI: C0040411
Disease: Tongue Neoplasms
Tongue Neoplasms
0.300 Biomarker group CTD_human Critical role of aquaporin 3 on growth of human esophageal and oral squamous cell carcinoma. 21401805 2011
CUI: C0546837
Disease: Malignant neoplasm of esophagus
Malignant neoplasm of esophagus
0.300 Biomarker disease CTD_human Critical role of aquaporin 3 on growth of human esophageal and oral squamous cell carcinoma. 21401805 2011
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm
0.300 Biomarker disease CTD_human Collectively, our results provide evidence for AQP3-facilitated ovarian cancer cell migration, suggesting a novel function for AQP3 expression in high-grade tumors. 18214481 2008
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.300 Biomarker disease CTD_human Collectively, our results provide evidence for AQP3-facilitated ovarian cancer cell migration, suggesting a novel function for AQP3 expression in high-grade tumors. 18214481 2008
CUI: C0162283
Disease: Nephrogenic Diabetes Insipidus
Nephrogenic Diabetes Insipidus
0.210 Biomarker disease MGD Nephrogenic diabetes insipidus in mice lacking aquaporin-3 water channels. 10737773 2000
CUI: C0162283
Disease: Nephrogenic Diabetes Insipidus
Nephrogenic Diabetes Insipidus
0.210 Biomarker disease BEFREE Nephrogenic diabetes insipidus in mice lacking aquaporin-3 water channels. 10737773 2000
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.200 Biomarker disease RGD Our findings indicated that dynamic changes of AQP3, -4, -5 and -8 expression could contribute to the development of cerebral edema after brain ischemia. 19616516 2009