AQP3 and AQP5 are strongly expressed in cancer tissues and AQP3-mediated H<sub>2</sub>O<sub>2</sub> transport has been related to breast cancer cell migration, but studies with human AQP5 are lacking.
These results suggest that AQP3 has a role in multiple aspects of breast cancer cell pathophysiology and therefore represents a novel target for therapeutic intervention.
Moreover, a multivariate survival analysis revealed that AQP3 expression was an independent prognostic marker of disease-free survival (DFS): hazard ratio (HR)=3.137, 95% confidence interval (CI)=1.079-9.125, p=0.036; distant DFS (DDFS): HR=2.784, 95%CI=0.921-8.414, p=0.070, for the HER2-over-expressing EBC patients.