IL15, interleukin 15, 3600

N. diseases: 426; N. variants: 10
Disease: Hepatitis C ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0019196
Disease: Hepatitis C
Hepatitis C 		0.050 Biomarker disease BEFREE Treatment of Huh7.5 cells with a MEK/ERK inhibitor abrogated the anti-HCV effects of IL-15 and IFN-γ and overexpression of ERK1 prevented HCV replication compared to control transfection. 29908921 2019
CUI: C0019196
Disease: Hepatitis C
Hepatitis C 		0.050 GeneticVariation disease BEFREE Age (<40years) (P=0.001), AST (P=0.029), ALP (P=0.028), HCV genotypes (P=0.005), HCV viral load (P=0.026), IL15 rs10833 (AA) genotype (P<0.001), and SCARB1 rs10846744 (CC) genotype (P=0.001) were strongly associated with SVR. 28827115 2017
CUI: C0019196
Disease: Hepatitis C
Hepatitis C 		0.050 GeneticVariation disease BEFREE The aim was to analyze whether IL15 rs10833 is associated with liver disease severity and response to pegylated-interferon-alpha plus ribavirin (pegIFN-alpha/RBV) therapy in human immunodeficiency virus (HIV)-/HCV-co-infected patients. 26836972 2016
CUI: C0019196
Disease: Hepatitis C
Hepatitis C 		0.050 AlteredExpression disease BEFREE We analysed the hepatic levels of IL-7, IL-15, IL-15Rα and interferon regulatory factors (IRF) in patients with chronic hepatitis C (CHC) (78% genotype 1) and the role of IRF1 and IRF2 on IL-7 and IL-15Rα expression in Huh7 cells with or without hepatitis C virus (HCV) replicon. 23787026 2014
CUI: C0019196
Disease: Hepatitis C
Hepatitis C 		0.050 Biomarker disease BEFREE In vitro culture of purified CD56bright NK cells with HCV-core protein in the presence of IL-15 maintained a significant proportion of NKs in the CD56bright state. 25076408 2014